HIGENAMINE

OTHER NAME(S):

1-[(4-Hydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol; 1-(p-hydroxybenzyl)-6,7-Dihydroxy-1,2,3,4-Tetrahydroisoquinolin; 1(S)-Norcoclaurine; dl-Demethylcoclaurine; DMC; Higénamine; Higenamine Hydrobromide; Higenamine Hydrochloride; Higenamine Oxalate; Higenamine Tartrate; Norcoclaurine; O-Demethylcoclaurine.<br/><br/>

Overview

Overview Information

Higenamine is a chemical found in several plants including aconite, asarum, lotus, and Lamarck's bedstraw, sacred bamboo, and others.

Higenamine is showing up in products promoted as a pre-workout supplement for improving athletic performance. However, higenamine is prohibited in sports. It is on the World Anti-Doping Agency (WADA) 2017 Prohibited List.

How does it work?

Higenamine works like a stimulant. In some parts of the body it causes tissues to relax. In other parts of the body, such as the heart, it causes tissue to contract. It seems to increase heart contractions and speed up the heart rate.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Weight loss.
  • Athletic performance.
  • Cough.
  • Asthma.
  • Breathing disorders.
  • Heart failure.
  • Slow heart rate.
  • Heart disease.
  • Erectile dysfunction.
  • Other conditions.
More evidence is needed to rate higenamine for these uses.

Side Effects

Side Effects & Safety

Higenamine is POSSIBLY UNSAFE when taken by mouth. Higenamine is one of the main chemicals in a plant called aconite. Aconite has been shown to cause serious heart-related side effects including arrhythmias and even death. These side effects from aconite ingestions may, in part, be caused by the higenamine chemical.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough information to know if higenamine is safe during pregnancy and breast feeding. It should be avoided.

Irregular heartbeat (heart arrhythmia): Higenamine might cause a rapid heartbeat. Therefore it could potentially worsen an irregular heartbeat. If you have an irregular heartbeat, do not take higenamine.

Surgery: Higenamine acts like a stimulant, so it might interfere with surgery by increasing heart rate. Stop taking higenamine at least 2 weeks before a scheduled surgery.

Interactions

Interactions?

We currently have no information for HIGENAMINE Interactions.

Dosing

Dosing

The appropriate dose of higenamine depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for higenamine. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Bai G, Yang Y, Shi Q, et al. Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist1. Acta Pharmacol Sin 2008;29:1187-94. View abstract.
  • Bao YX, Yu GR, Xu JM, et al. Effect of acute higenamine administration on bradyarrhythmias and HIS bundle. A clinical study of 14 cases and animal experiment on dogs. Chin Med J 1982;95:781-4. View abstract.
  • But PP, Tai YT, Young K. Three fatal cases of herbal aconite poisoning. Vet Hum Toxicol 1994;36:212-5. View abstract.
  • Feng S, Hu P, Jiang J. Determination of higenamine in human plasma and urine using liquid chromatography coupled to positive electrospray ionization tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2011;879:763-8. View abstract.
  • Huang XN, Shi JS, Lu WQ, Liu GX. Antiasthmatic effect of higenamine. Chin Pharm Bull 1985;20:462-4.
  • Kam SC, Do JM, Choi JH, et al. The relaxation effect and mechanism of action of higenamine in the rat corpus cavernosum. Int J Impot Res 2012;24:77-83. View abstract.
  • Kang YJ, Lee YS, Lee GW, et al. Inhibition of activation of nuclear factor kappaB is responsible for inhibition of inducible nitric oxide synthase expression by higenamine, an active component of aconite root. J Pharmacol Exp Ther 1999;291:314-20. View abstract.
  • Kosuge T, Yokota M, Nagasawa M. Studies on cardiac principle in aconite roots. 1. Isolation and structural determination of higenamine. J Pharm Soc Jap 1978;98:1370-5. View abstract.
  • Lin CC, Chan TY, Deng JF. Clinical features and management of herb-induced aconitine poisoning. Ann Emerg Med 2004;43:574-9. View abstract.
  • Liu WH, Zhou YP, Zeng GY. Effects of dl-demethylcoclaurine on experimental heart failure. Acta Pharm Sinica 1988;23:81-5. View abstract.
  • Park CW, Chang KC, Lim JK. Effects of higenamine on isolated heart adrenoceptor of rabbit. Arch Int Pharmacodyn Ther 1984;267:279-88. View abstract.
  • Tai YT, But PP, Young K, et al. Cardiotoxicity after accidental herb-induced aconite poisoning. Lancet 1992;340:1254-6. View abstract.
  • Tsukiyama M, Ueki T, Yasuda Y, et al. Beta2-adrenoceptor-mediated tracheal relaxation induced by higenamine from Nandina domestica Thunberg. Planta Med 2009;75:1393-9. View abstract.
  • Wagner H, Reiter M, Ferstl W. New drugs with cardiotonic activity. Part 1. Chemistry and pharmacology of the cardiotonic active principle of Annona squamosa L. Planta Med 1980;40:77-85. View abstract.
  • Yeih DF, Chiang FT, Huang SKS. Successful treatment of aconitine induced life threatening ventricular tachyarrhythmia with amiodarone. Heart 2000;84:E8. View abstract.
  • Yun-Choi HS, Pyo MK, Park KM, et al. Anti-thrombotic effects of higenamine. Planta Med 2001;67:619-22. View abstract.
  • Zhang Z, Liu X, Tao Z, et al. Effects of higeramine on hemodynamics and its tolerability and safety, an experimental study. Zhonghua Yi Xue Za Zhi 2002;82:352-5. View abstract.
  • Bai G, Yang Y, Shi Q, et al. Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist1. Acta Pharmacol Sin 2008;29:1187-94. View abstract.
  • Bao YX, Yu GR, Xu JM, et al. Effect of acute higenamine administration on bradyarrhythmias and HIS bundle. A clinical study of 14 cases and animal experiment on dogs. Chin Med J 1982;95:781-4. View abstract.
  • But PP, Tai YT, Young K. Three fatal cases of herbal aconite poisoning. Vet Hum Toxicol 1994;36:212-5. View abstract.
  • Feng S, Hu P, Jiang J. Determination of higenamine in human plasma and urine using liquid chromatography coupled to positive electrospray ionization tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2011;879:763-8. View abstract.
  • Grucza K, Kwiatkowska D, Kowalczyk K, Wicka M, Szutowski M, Cholbinski P. Analysis for higenamine in urine by means of UHPLC/MS/MS: Interpretation of results. Drug Test Anal. 2017. View abstract.
  • Huang XN, Shi JS, Lu WQ, Liu GX. Antiasthmatic effect of higenamine. Chin Pharm Bull 1985;20:462-4.
  • Jeter J, DeZee KJ, Kennedy L. A Case of Paraspinal Muscle Rhabdomyolysis in a 22-Year-Old Male After Ingesting a Supplement Containing Higenamine. Mil Med. 2015;180(7):e847-9. View abstract.
  • Kam SC, Do JM, Choi JH, et al. The relaxation effect and mechanism of action of higenamine in the rat corpus cavernosum. Int J Impot Res 2012;24:77-83. View abstract.
  • Kang YJ, Lee YS, Lee GW, et al. Inhibition of activation of nuclear factor kappaB is responsible for inhibition of inducible nitric oxide synthase expression by higenamine, an active component of aconite root. J Pharmacol Exp Ther 1999;291:314-20. View abstract.
  • Kosuge T, Yokota M, Nagasawa M. Studies on cardiac principle in aconite roots. 1. Isolation and structural determination of higenamine. J Pharm Soc Jap 1978;98:1370-5. View abstract.
  • Lin CC, Chan TY, Deng JF. Clinical features and management of herb-induced aconitine poisoning. Ann Emerg Med 2004;43:574-9. View abstract.
  • Liu WH, Zhou YP, Zeng GY. Effects of dl-demethylcoclaurine on experimental heart failure. Acta Pharm Sinica 1988;23:81-5. View abstract.
  • Liu Y, Santillo MF. Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. Drug Test Anal. 2016;8(3-4):307-10. View abstract.
  • Park CW, Chang KC, Lim JK. Effects of higenamine on isolated heart adrenoceptor of rabbit. Arch Int Pharmacodyn Ther 1984;267:279-88. View abstract.
  • Tai YT, But PP, Young K, et al. Cardiotoxicity after accidental herb-induced aconite poisoning. Lancet 1992;340:1254-6. View abstract.
  • Tsukiyama M, Ueki T, Yasuda Y, et al. Beta2-adrenoceptor-mediated tracheal relaxation induced by higenamine from Nandina domestica Thunberg. Planta Med 2009;75:1393-9. View abstract.
  • Wagner H, Reiter M, Ferstl W. New drugs with cardiotonic activity. Part 1. Chemistry and pharmacology of the cardiotonic active principle of Annona squamosa L. Planta Med 1980;40:77-85. View abstract.
  • Yeih DF, Chiang FT, Huang SKS. Successful treatment of aconitine induced life threatening ventricular tachyarrhythmia with amiodarone. Heart 2000;84:E8. View abstract.
  • Yun-Choi HS, Pyo MK, Park KM, et al. Anti-thrombotic effects of higenamine. Planta Med 2001;67:619-22. View abstract.
  • Zhang N, Lian Z, Peng X, Li Z, Zhu H. Applications of Higenamine in pharmacology and medicine. J Ethnopharmacol. 2017;196:242-252. View abstract.
  • Zhang Z, Liu X, Tao Z, et al. Effects of higeramine on hemodynamics and its tolerability and safety, an experimental study. Zhonghua Yi Xue Za Zhi 2002;82:352-5. View abstract.

More Resources for HIGENAMINE

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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