Overview

Acacia rigidula is a shrub that grows in southwest and west Texas, as well as in the northern states of Mexico. The chemicals in Acacia rigidula might have stimulant effects, which is why it is used in some weight loss and athletic performance supplements.

Many dietary supplements that list Acacia rigidula as an ingredient have been shown to contain large amounts of the chemical phenethylamine. While phenethylamine is found in Acacia rigidula leaves naturally, the amounts found in these supplements is often greater than would be expected from the plant parts alone.

In addition to phenethylamine, many supplements listing Acacia rigidula as an ingredient have been found to contain another unlisted ingredient called beta-methylphenethylamine (BMPEA). This ingredient is a stimulant similar to amphetamine. But unlike phenethylamine, it is not found naturally in Acacia rigidula or any other known plants. In April 2015, the U.S. Food and Drug Administration (FDA) stated that BMPEA does not meet the definition of a dietary ingredient. Therefore, any products containing BMPEA are considered misbranded.

How does it work ?

Acacia rigidula contains many different chemicals that have stimulant effects. Because of this, it is often promoted for weight loss and athletic performance. But many products listing Acacia rigidula as an ingredient also contain an amphetamine-like chemical called beta-methylphenethylamine (BMPEA).

Uses & Effectiveness ?

Insufficient Evidence for

  • Weight loss.
  • Athletic performance.
  • Other conditions.
More evidence is needed to rate Acacia rigidula for these uses.

Side Effects

When taken by mouth: Acacia rigidula is POSSIBLY UNSAFE. Acacia rigidula contains chemicals thought to have stimulant effects. There have been several reports of increased heart rate and heart palpitations in people taking products containing Acacia rigidula and other stimulants. There is also one reported case of cardiac arrest. It's unclear if these side effects were caused by Acacia rigidula or other stimulants in these products.

Special Precautions and Warnings

When taken by mouth: Acacia rigidula is POSSIBLY UNSAFE. Acacia rigidula contains chemicals thought to have stimulant effects. There have been several reports of increased heart rate and heart palpitations in people taking products containing Acacia rigidula and other stimulants. There is also one reported case of cardiac arrest. It's unclear if these side effects were caused by Acacia rigidula or other stimulants in these products.

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking Acacia rigidula if you are pregnant or breast feeding. Stay on the safe side and avoid use.

High blood pressure: Some chemicals in Acacia rigidula have stimulant effects. Many products that list Acacia rigidula as an ingredient have also been found to contain a chemical called beta-methylphenethylamine (BMPEA). BMPEA and other stimulants can increase blood pressure and heart rate. In theory, taking Acacia rigidula supplements might make high blood pressure worse.

Surgery: Some chemicals in Acacia rigidula have stimulant effects. Many products that list Acacia rigidula as an ingredient have also been found to contain a chemical called beta-methylphenethylamine (BMPEA). BMPEA and other stimulants can increase blood pressure and heart rate. In theory, taking Acacia rigidula supplements might interfere with surgery by increasing blood pressure and heart rate. Stop taking Acacia rigidula supplements at least 2 weeks before surgery.

Interactions ?

    Moderate Interaction

    Be cautious with this combination

  • Stimulant Drugs interacts with ACACIA RIGIDULA

    Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heart rate. Some chemicals in Acacia rigidula also have stimulant effects. Many products that list Acacia rigidula as an ingredient have also been found to contain an amphetamine-like chemical called beta-methylphenethylamine (BMPEA). In theory, taking Acacia rigidula along with stimulant drugs might cause serious problems, such as causing heart rate and blood pressure to become too high.

    Some stimulant drugs include amphetamine, caffeine, diethylpropion (Tenuate), methylphenidate, phentermine (Ionamin), pseudoephedrine (Sudafed, others), and many others.

  • Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with ACACIA RIGIDULA

  • Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with ACACIA RIGIDULA

Dosing

The appropriate dose of Acacia rigidula depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for Acacia rigidula (in children/in adults). Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.