COLLARD

OTHER NAME(S):

Berza, Brassica oleracea var. acephala, Brassica oleracea var. viridis, Chou Cavalier, Collard Greens, Cow Cabbage, Dalmatian Cabbage, Morris Heading, Spring Heading Cabbage, Tall Kale, Tree Kale, Winter Greens.<br/><br/>

Overview

Overview Information

Collard is a dark, leafy, vegetable that is commonly eaten as a food source. Collard leaves can also be eaten as a medicine.

Collard is taken by mouth as an antioxidant; for anemia, heart disease, constipation, diabetes, an eye disorder that causes damage to the optic nerve (glaucoma), high cholesterol, loss of vision (macular degeneration), and weight loss; and to prevent bladder cancer, breast cancer, prostate cancer, and scurvy.

How does it work?

Collard contains chemicals that are thought to help prevent cancer. Chemicals in collard might also have antioxidant activity.
Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Bladder cancer: There is some evidence that people who eat large amounts of collard and related vegetables have a lower risk of developing bladder cancer.
  • Breast cancer: Some early research suggests that eating collard and related vegetables is linked with a slight increase in the risk of breast cancer in premenopausal women. However, eating collard and related vegetables is not linked with a higher risk of breast cancer in postmenopausal women.
  • Prostate cancer: Some early research shows that eating larger amounts of collard and related vegetables is not linked with a lower risk of developing prostate cancer.
  • Anemia.
  • Heart disease.
  • Constipation.
  • Diabetes.
  • An eye disorder that causes damage to the optic nerve (glaucoma).
  • Hypercholesterolemia.
  • Loss of vision (macular degeneration).
  • Weight loss.
  • Scurvy.
  • Other conditions.
More evidence is needed to rate the effectiveness of collard for these uses.

Side Effects

Side Effects & Safety

Collard is LIKELY SAFE when consumed in food amounts. It isn't known if collard is safe or what the possible side effects might be when taken in medicinal amounts.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough information about the safety of eating collard in medicinal amounts during pregnancy or breast-feeding. Stay on the safe side and stick to usual food amounts.

Interactions

Interactions?

We currently have no information for COLLARD Interactions.

Dosing

Dosing

The appropriate dose of collard depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for collard. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Panter, K. E. and James, L. F. Natural plant toxicants in milk: a review. J Anim Sci 1990;68(3):892-904. View abstract.
  • Aggarwal, B. B. and Ichikawa, H. Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle 2005;4(9):1201-1215. View abstract.
  • Bradfield CA, Bjeldanes LF. Modification of carcinogen metabolism by indolylic autolysis products of Brassica oleraceae. Adv Exp Med Biol 1991;289:153-163. View abstract.
  • Cohen, J. H., Kristal, A. R., and Stanford, J. L. Fruit and vegetable intakes and prostate cancer risk. J Natl.Cancer Inst. 1-5-2000;92(1):61-68. View abstract.
  • Conaway, C. C., Yang, Y. M., and Chung, F. L. Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans. Curr Drug Metab 2002;3(3):233-255. View abstract.
  • Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Cancer 2004;50(2):161-167. View abstract.
  • Erkkil√§ AT, Lichtenstein AH, Dolnikowski GG, et al. Plasma transport of vitamin K in men using deuterium-labeled collard greens. Metabolism 2004;53(2):215-21. View abstract.
  • Farnham MW, Davis EH, Morgan JT, Smith JP. Neglected landraces of collard (Brassica oleracea L. var. viridis) from the Carolinas (USA). Genet Resour Crop Evol 2008;55:797-801.
  • Firestone, G. L. and Bjeldanes, L. F. Indole-3-carbinol and 3-3'-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter-Sp1 transcription factor interactions. J Nutr 2003;133(7 Suppl):2448S-2455S. View abstract.
  • Gamet-Payrastre L. Signaling pathways and intracellular targets of sulforaphane mediating cell cycle arrest and apoptosis. Curr Cancer Drug Targets 2006;6(2):135-145. View abstract.
  • Gaudet MM, Britton JA, Kabat GC, et al. Fruits, vegetables, and micronutrients in relation to breast cancer modified by menopause and hormone receptor status. Cancer Epidemiol Biomarkers Prev 2004;13(9):1485-94. View abstract.
  • Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. View abstract.
  • Manchali S, Chidambara Murthy KN, Patil BS. Crucial facts about health benefits of popular cruciferous vegetables. J Funct Foods 2012;4:94-106.
  • Morel F, Langouet S, Maheo K, Guillouzo A. The use of primary hepatocyte cultures for the evaluation of chemoprotective agents. Cell Biol Toxicol 1997;13(4-5):323-329. View abstract.
  • Myzak MC, Dashwood RH. Chemoprotection by sulforaphane: keep one eye beyond Keap1. Cancer Lett 2006;233(2):208-218. View abstract.
  • Osborne MP. Chemoprevention of breast cancer. Surg Clin North Am 1999;79(5):1207-1221. View abstract.
  • Park EJ, Pezzuto JM. Botanicals in cancer chemoprevention. Cancer Metastasis Rev 2002;21:231-55. View abstract.
  • Steinkellner, H., Rabot, S., Freywald, C., Nobis, E., Scharf, G., Chabicovsky, M., Knasmuller, S., and Kassie, F. Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens. Mutat Res 2001;480-481:285-297. View abstract.
  • Stoewsand GS. Bioactive organosulfur phytochemicals in Brassica oleracea vegetables--a review. Food Chem Toxicol 1995;33:537-43. View abstract.
  • United States Department of Agriculture Agricultural Research Service. National Nutrient Database for Standard Reference Release 27. Basic Report: 11161, Collards,raw. Available at: http://ndb.nal.usda.gov/ndb/foods/show/2963?fgcd=&manu=&lfacet=&format=&count=&max=35&offset=&sort=&qlookup=collard.
  • van Poppel G, Verhoeven DT, Verhagen H, Goldbohm RA. Brassica vegetables and cancer prevention. Epidemiology and mechanisms. Adv Exp Med Biol 1999;472:159-68. View abstract.
  • Verhoeven DT, Verhagen H, Goldbohm RA, van den Brandt PA, van Poppel G. A review of mechanisms underlying anticarcinogenicity by brassica vegetables. Chem Biol Interact 1997;103(2):79-129. View abstract.
  • Wagner AE, Huebbe P, Konishi T, et al. Free radical scavenging and antioxidant activity of ascorbigen versus ascorbic acid: studies in vitro and in cultured human keratinocytes. J Agric Food Chem 2008;56(24):11694-11699. View abstract.
  • Zhao H, Lin J, Grossman HB, et al. Dietary isothiocyanates, GSTM1, GSTT1, NAT2 polymorphisms and bladder cancer risk. Int J Cancer 2007;120:2208-13. View abstract.
  • Panter, K. E. and James, L. F. Natural plant toxicants in milk: a review. J Anim Sci 1990;68(3):892-904. View abstract.
  • Aggarwal, B. B. and Ichikawa, H. Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle 2005;4(9):1201-1215. View abstract.
  • Bradfield CA, Bjeldanes LF. Modification of carcinogen metabolism by indolylic autolysis products of Brassica oleraceae. Adv Exp Med Biol 1991;289:153-163. View abstract.
  • Cohen, J. H., Kristal, A. R., and Stanford, J. L. Fruit and vegetable intakes and prostate cancer risk. J Natl.Cancer Inst. 1-5-2000;92(1):61-68. View abstract.
  • Conaway, C. C., Yang, Y. M., and Chung, F. L. Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans. Curr Drug Metab 2002;3(3):233-255. View abstract.
  • Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Cancer 2004;50(2):161-167. View abstract.
  • Erkkil√§ AT, Lichtenstein AH, Dolnikowski GG, et al. Plasma transport of vitamin K in men using deuterium-labeled collard greens. Metabolism 2004;53(2):215-21. View abstract.
  • Farnham MW, Davis EH, Morgan JT, Smith JP. Neglected landraces of collard (Brassica oleracea L. var. viridis) from the Carolinas (USA). Genet Resour Crop Evol 2008;55:797-801.
  • Firestone, G. L. and Bjeldanes, L. F. Indole-3-carbinol and 3-3'-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter-Sp1 transcription factor interactions. J Nutr 2003;133(7 Suppl):2448S-2455S. View abstract.
  • Gamet-Payrastre L. Signaling pathways and intracellular targets of sulforaphane mediating cell cycle arrest and apoptosis. Curr Cancer Drug Targets 2006;6(2):135-145. View abstract.
  • Gaudet MM, Britton JA, Kabat GC, et al. Fruits, vegetables, and micronutrients in relation to breast cancer modified by menopause and hormone receptor status. Cancer Epidemiol Biomarkers Prev 2004;13(9):1485-94. View abstract.
  • Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. View abstract.
  • Manchali S, Chidambara Murthy KN, Patil BS. Crucial facts about health benefits of popular cruciferous vegetables. J Funct Foods 2012;4:94-106.
  • Morel F, Langouet S, Maheo K, Guillouzo A. The use of primary hepatocyte cultures for the evaluation of chemoprotective agents. Cell Biol Toxicol 1997;13(4-5):323-329. View abstract.
  • Myzak MC, Dashwood RH. Chemoprotection by sulforaphane: keep one eye beyond Keap1. Cancer Lett 2006;233(2):208-218. View abstract.
  • Osborne MP. Chemoprevention of breast cancer. Surg Clin North Am 1999;79(5):1207-1221. View abstract.
  • Park EJ, Pezzuto JM. Botanicals in cancer chemoprevention. Cancer Metastasis Rev 2002;21:231-55. View abstract.
  • Steinkellner, H., Rabot, S., Freywald, C., Nobis, E., Scharf, G., Chabicovsky, M., Knasmuller, S., and Kassie, F. Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens. Mutat Res 2001;480-481:285-297. View abstract.
  • Stoewsand GS. Bioactive organosulfur phytochemicals in Brassica oleracea vegetables--a review. Food Chem Toxicol 1995;33:537-43. View abstract.
  • United States Department of Agriculture Agricultural Research Service. National Nutrient Database for Standard Reference Release 27. Basic Report: 11161, Collards,raw. Available at: http://ndb.nal.usda.gov/ndb/foods/show/2963?fgcd=&manu=&lfacet=&format=&count=&max=35&offset=&sort=&qlookup=collard.
  • van Poppel G, Verhoeven DT, Verhagen H, Goldbohm RA. Brassica vegetables and cancer prevention. Epidemiology and mechanisms. Adv Exp Med Biol 1999;472:159-68. View abstract.
  • Verhoeven DT, Verhagen H, Goldbohm RA, van den Brandt PA, van Poppel G. A review of mechanisms underlying anticarcinogenicity by brassica vegetables. Chem Biol Interact 1997;103(2):79-129. View abstract.
  • Wagner AE, Huebbe P, Konishi T, et al. Free radical scavenging and antioxidant activity of ascorbigen versus ascorbic acid: studies in vitro and in cultured human keratinocytes. J Agric Food Chem 2008;56(24):11694-11699. View abstract.
  • Zhao H, Lin J, Grossman HB, et al. Dietary isothiocyanates, GSTM1, GSTT1, NAT2 polymorphisms and bladder cancer risk. Int J Cancer 2007;120:2208-13. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.