JACKFRUIT: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Jackfruit (Artocarpus heterophyllus) is a tree native to India. Its fruit and seeds are eaten as food. Other plant parts are used in Ayurvedic medicine.

Jackfruit leaves and roots contain chemicals that might help control blood sugar increases after eating. Its fruit is a source of vitamin A, fiber, and protein.

People use jackfruit for diabetes, wound healing, and many other conditions, but there is no good scientific evidence to support these uses.

Uses & Effectiveness ?

We currently have no information for JACKFRUIT overview.

Side Effects

When taken by mouth: There isn't enough reliable information to know if jackfruit is safe or what the side effects might be. Its fruit might cause allergic reactions in some people.

Special Precautions and Warnings

When taken by mouth: There isn't enough reliable information to know if jackfruit is safe or what the side effects might be. Its fruit might cause allergic reactions in some people.

Pregnancy and breast-feeding: There isn't enough reliable information to know if jackfruit is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Allergy to birch pollen or latex: People who are allergic to birch pollen or latex might also be allergic to jackfruit.

Surgery: Jackfruit might cause bleeding and too much drowsiness if combined with medications used during and after surgery. Stop taking jackfruit at least 2 weeks before scheduled surgery.

Interactions ?

Moderate Interaction

Be cautious with this combination

Medications for diabetes (Antidiabetes drugs) interacts with JACKFRUIT
Jackfruit might lower blood sugar levels. Taking jackfruit along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Sedative medications (CNS depressants) interacts with JACKFRUIT
Jackfruit seeds might cause sleepiness and slowed breathing. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Taking jackfruit with sedative medications might cause breathing problems and/or too much sleepiness.

Dosing

There isn't enough reliable information to know what an appropriate dose of jackfruit might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

View References

REFERENCES:

Alila P, Sanyal D. "Jackfruit in northern and eastern India." The Jackfruit. Ed. Valvi SG, Peter KV, Thottappilly G. New Delhi: Studium Press, 2011. 409-420.

Barua AG, Boruah BR. Minerals and functional groups present in the jackfruit seed: a spectroscopic investigation. Int J Food Sci Nutr 2004;55(6):479-483. View abstract.

Blasco E, Ngoc LD, Aucouturier P, Preud'Homme JL, Barra A. Mitogenic activity of new lectins from seeds of wild Artocarpus species from Vietnam. C R Acad Sci III 1996;319(5):405-409. View abstract.

Bolhaar ST, Ree R, Bruijnzeel-Koomen CA, Knulst AC, Zuidmeer L. Allergy to jackfruit: a novel example of Bet v 1-related food allergy. Allergy 2004;59(11):1187-1192. View abstract.

Bunn-Moreno MM, Campos-Neto A. Lectin(s) extracted from seeds of Artocarpus integrifolia (jackfruit): potent and selective stimulator(s) of distinct human T and B cell functions. J Immunol 1981;127(2):427-429. View abstract.

Fernando MR, Wickramasinghe N, Thabrew MI, Ariyananda PL, Karunanayake EH. Effect of Artocarpus heterophyllus and Asteracanthus longifolia on glucose tolerance in normal human subjects and in maturity-onset diabetic patients. J Ethnopharmacol 1991;31(3):277-282. View abstract.

Hagiwara K, Collet-Cassart D, Kobayashi K, Vaerman JP. Jacalin: isolation, characterization, and influence of various factors on its interaction with human IgA1, as assessed by precipitation and latex agglutination. Mol Immunol 1988;25(1):69-83. View abstract.

Kabir S, Aebersold R, Daar AS. Identification of a novel 4 kDa immunoglobulin-A-binding peptide obtained by the limited proteolysis of jacalin. Biochim Biophys Acta 1993;1161(2-3):194-200. View abstract.

Kabir S, Daar AS. The composition and properties of jacalin, a lectin of diverse applications obtained from the jackfruit (Artocarpus heterophyllus) seeds. Immunol Invest 1994;23(3):167-188. View abstract.

Khan MR, Omoloso AD, Kihara M. Antibacterial activity of Artocarpus heterophyllus. Fitoterapia 2003;74(5):501-505. View abstract.

Lakheda S, Devalia R, Jain UK, et al. Anti-inflammatory activity of Artocarpus heterophyllus bark. Der Pharmacia Sinica 2011;2(2):127-130.

Ratnasooriya WD, Jayakody JR. Artocarpus heterophyllus seeds inhibits sexual competence but not fertility of male rats. Indian J Exp Biol 2002;40(3):304-308. View abstract.

Roque-Barreira MC, Campos-Neto A. Jacalin: an IgA-binding lectin. J Immunol 1985;134(3):1740-1743. View abstract.

Soares MB, Armada JL, Soares VM, Seuanez HN. Artocarpus integrifolia lectin(s): use and applications in chromosome studies of lymphocyte cultures. Cytobios 1982;34(135-36):165-174. View abstract.

Tachibana K, Nakamura S, Wang H, et al. Elucidation of binding specificity of Jacalin toward O-glycosylated peptides: quantitative analysis by frontal affinity chromatography. Glycobiology 2006;16(1):46-53. View abstract.

Thomas CA. Jackfruit, Artocarpus heterophyllus (Moraceae), as source of food and income. Econ Bot 1980;34(2):154-159.

Trindade MB, Lopes JL, Soares-Costa A, et al. Structural characterization of novel chitin-binding lectins from the genus Artocarpus and their antifungal activity. Biochim Biophys Acta 2006;1764(1):146-152. View abstract.

Wetprasit N, Threesangsri W, Klamklai N, Chulavatnatol M. Jackfruit lectin: properties of mitogenicity and the inhibition of herpesvirus infection. Jpn J Infect Dis 2000;53(4):156-161. View abstract.

Alila P, Sanyal D. "Jackfruit in northern and eastern India." The Jackfruit. Ed. Valvi SG, Peter KV, Thottappilly G. New Delhi: Studium Press, 2011. 409-420.

Blasco E, Ngoc LD, Aucouturier P, Preud'Homme JL, Barra A. Mitogenic activity of new lectins from seeds of wild Artocarpus species from Vietnam. C R Acad Sci III 1996;319(5):405-409. View abstract.

Bolhaar ST, Ree R, Bruijnzeel-Koomen CA, Knulst AC, Zuidmeer L. Allergy to jackfruit: a novel example of Bet v 1-related food allergy. Allergy 2004;59(11):1187-1192. View abstract.

Fang SC, Hsu CL, Yen GC. Anti-inflammatory effects of phenolic compounds isolated from the fruits of Artocarpus heterophyllus. J Agric Food Chem. 2008;56(12):4463-8. View abstract.

Hettiaratchi UP, Ekanayake S, Welihinda J. Nutritional assessment of a jackfruit (Artocarpus heterophyllus) meal. Ceylon Med J. 2011;56(2):54-8. View abstract.

Jalil M, Hostoffer R, Wu SS. Jackfruit Anaphylaxis in a Latex Allergic Non-Healthcare Worker. Allergy Rhinol (Providence) 2021;12:21526567211009195. View abstract.

Khan MR, Omoloso AD, Kihara M. Antibacterial activity of Artocarpus heterophyllus. Fitoterapia 2003;74(5):501-505. View abstract.

Prakash O, Kumar R, Mishra A, Gupta R. Artocarpus heterophyllus (Jackfruit): An overview. Phcog Rev [serial online] 2009 [Accessed: January 16, 2019];3:353-8. Available at: https://www.phcogrev.com/text.asp?2009/3/6/353/59534.

Rao AG, Naik KS, Unnikrishnan AG, Joseph J. Efficacy of green jackfruit flour as a medical nutrition therapy replacing rice or wheat in patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study. Nutr Diabetes 2021;11(1):18. View abstract.

Ratnasooriya WD, Jayakody JR. Artocarpus heterophyllus seeds inhibits sexual competence but not fertility of male rats. Indian J Exp Biol 2002;40(3):304-308. View abstract.

Roque-Barreira MC, Campos-Neto A. Jacalin: an IgA-binding lectin. J Immunol 1985;134(3):1740-1743. View abstract.

Siritapetawee J, Thammasirirak S. Purification and characterization of a heteromultimeric glycoprotein from Artocarpus heterophylluslatex with an inhibitory effect on human blood coagulation. Acta Biochim Pol. 2011;58(4):521-8. View abstract.

Siritapetawee J, Thumanu K, Sojikul P, Thammasirirak S. A novel serine protease with human fibrino(geno)lytic activities from Artocarpus heterophylluslatex. Biochim Biophys Acta. 2012;1824(7):907-12. View abstract.

Soares MB, Armada JL, Soares VM, Seuanez HN. Artocarpus integrifolia lectin(s): use and applications in chromosome studies of lymphocyte cultures. Cytobios 1982;34(135-36):165-174. View abstract.

Thomas CA. Jackfruit, Artocarpus heterophyllus (Moraceae), as source of food and income. Econ Bot 1980;34(2):154-159.

Wetprasit N, Threesangsri W, Klamklai N, Chulavatnatol M. Jackfruit lectin: properties of mitogenicity and the inhibition of herpesvirus infection. Jpn J Infect Dis 2000;53(4):156-161. View abstract.

Wongrakpanich S, Klaewsongkram J, Chantaphakul H, Ruxrungtham K. Jackfruit anaphylaxis in a latex allergic patient. Asian Pac J Allergy Immunol. 2015;33(1):65-8. View abstract.

Zeng S, Cao J, Chen Y, et al. Polysaccharides from Artocarpus heterophyllus Lam. (jackfruit) pulp improves intestinal barrier functions of high fat diet-induced obese rats. Front Nutr 2022;9:1035619. View abstract.

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

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