Glycomacropeptide is a type of protein. It is formed during the process of making cheese. Unlike many other proteins, glycomacropeptide contains only very small amounts of the amino acidphenylalanine.

People take glycomacropeptide for an inherited disorder that increases levels of phenylalanine in the blood (phenylketonuria or PKU), gout, obesity, and many other conditions, but there is no good scientific evidence to support these uses.

How does it work ?

Glycomacropeptide contains very low levels of phenylalanine, which might make it a better protein source for people with phenylketonuria.

Uses & Effectiveness ?

Insufficient Evidence for

  • Gout. Early research shows that taking skim milk powder fortified with glycomacropeptide and a specific milk fat extract reduces gout flares. It might also reduce pain during a gout flare.
  • Obesity. Replacing one or two meals per day with a supplement containing glycomacropeptide does not help to reduce weight more than taking a supplement with skim milk powder.
  • An inherited disorder that increases levels of phenylalanine in the blood (phenylketonuria or PKU). Early research shows that replacing part of the daily dose of a regular phenylalanine-free protein supplement with glycomacropeptide maintains blood levels of the amino acid phenylalanine. In surveys, people with phenylketonuria seem to prefer supplements containing glycomacropeptide over regular phenylalanine-free protein supplements.
  • Bipolar disorder.
  • Dental cavities.
  • Diabetes.
  • Gout.
  • Heart disease.
  • Infant development.
  • Liver disease.
  • Other conditions.
More evidence is needed to rate the effectiveness of glycomacropeptide for these uses.

Side Effects

When taken by mouth: Glycomacropeptide is POSSIBLY SAFE when taken as a food supplement for up to one year.

Special Precautions and Warnings

When taken by mouth: Glycomacropeptide is POSSIBLY SAFE when taken as a food supplement for up to one year. Pregnancy and breast-feeding: There isn't enough reliable information to know if glycomacropeptide is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Children: Glycomacropeptide is POSSIBLY SAFE when taken by mouth as a food supplement for up to one year.

Interactions ?

We currently have no information for GLYCOMACROPEPTIDE overview.


The appropriate dose of glycomacropeptide depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for glycomacropeptide. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.