Overview
Avocado soy unsaponifiables are taken for osteoarthritis. They are also used for back pain, and hot flashes, but there is no good scientific evidence to support these uses.
Don't confuse avocado soy unsaponifiables with compounds made only from avocado, avocado sugar, soybean, or soybean oil.
How does it work ?
Uses & Effectiveness ?
Possibly Effective for
- Osteoarthritis. Clinical research shows that taking a specific type of avocado soy unsaponifiables (Piascledine 300, Laboratoires Expanscience) reduces pain and improves function by a small amount in people with osteoarthritis in the hip or knee. When used for a few years, avocado soy unsaponifiables might help to slow down how quickly the disease worsens. But not all research agrees.
Insufficient Evidence for
- Symptoms of menopause. Early research shows that taking a specific type of avocado soy unsaponifiables is as effective as taking HRT (hormone replacement therapy) for reducing hot flashes in women going through menopause.
- Obesity. Early research shows that taking a specific type of avocado soy unsaponifiables does not improve insulin levels in the blood of people who are obese.
- A group of painful conditions that affect the jaw joint and muscle (temporomandibular disorders or TMD). Early research shows that taking avocado soy unsaponifiables might reduce mouth pain and the amount of pain medication needed in women with TMD.
- Back pain.
- Other conditions.
Side Effects
Special Precautions and Warnings
Interactions ?
We currently have no information for AVOCADO SOY UNSAPONIFIABLES (ASU) overview.
Dosing
- For osteoarthritis: A specific product containing avocado soy unsaponifiables (Piascledine 300, Laboratoires Expanscience) 300 mg each day for up to 3 years.
Appelboom, T., Schuermans, J., Verbruggen, G., Henrotin, Y., and Reginster, J. Y. Symptoms modifying effect of avocado/soybean unsaponifiables (ASU) in knee osteoarthritis. A double blind, prospective, placebo-controlled study. Scand J Rheumatol 2001;30(4):242-247. View abstract.
Appelboom, T., Schuermans, J., Verbruggen, G., Henrotin, Y., and Reginster, J. Y. Symptoms modifying effect of avocado/soybean unsaponifiables (ASU) in knee osteoarthritis. A double blind, prospective, placebo-controlled study. Scand J Rheumatol 2001;30(4):242-247. View abstract.
Blotman, F., Maheu, E., Wulwik, A., Caspard, H., and Lopez, A. Efficacy and safety of avocado/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip. A prospective, multicenter, three-month, randomized, double-blind, placebo-controlled trial. Rev Rhum Engl Ed 1997;64(12):825-834. View abstract.
Blotman, F., Maheu, E., Wulwik, A., Caspard, H., and Lopez, A. Efficacy and safety of avocado/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip. A prospective, multicenter, three-month, randomized, double-blind, placebo-controlled trial. Rev Rhum Engl Ed 1997;64(12):825-834. View abstract.
Boumediene, K., Felisaz, N., Bogdanowicz, P., Galera, P., Guillou, G. B., and Pujol, J. P. Avocado/soya unsaponifiables enhance the expression of transforming growth factor beta1 and beta2 in cultured articular chondrocytes. Arthritis Rheum. 1999;42(1):148-156. View abstract.
Boumediene, K., Felisaz, N., Bogdanowicz, P., Galera, P., Guillou, G. B., and Pujol, J. P. Avocado/soya unsaponifiables enhance the expression of transforming growth factor beta1 and beta2 in cultured articular chondrocytes. Arthritis Rheum. 1999;42(1):148-156. View abstract.
Henrotin, Y. E., Labasse, A. H., Jaspar, J. M., De Groote, D. D., Zheng, S. X., Guillou, G. B., and Reginster, J. Y. Effects of three avocado/soybean unsaponifiable mixtures on metalloproteinases, cytokines and prostaglandin E2 production by human articular chondrocytes. Clin.Rheumatol. 1998;17(1):31-39. View abstract.
Henrotin, Y. E., Labasse, A. H., Jaspar, J. M., De Groote, D. D., Zheng, S. X., Guillou, G. B., and Reginster, J. Y. Effects of three avocado/soybean unsaponifiable mixtures on metalloproteinases, cytokines and prostaglandin E2 production by human articular chondrocytes. Clin.Rheumatol. 1998;17(1):31-39. View abstract.
Khayyal, M. T. and el Ghazaly, M. A. The possible "chondroprotective" effect of the unsaponifiable constituents of avocado and soya in vivo. Drugs Exp.Clin.Res. 1998;24(1):41-50. View abstract.
Khayyal, M. T. and el Ghazaly, M. A. The possible "chondroprotective" effect of the unsaponifiable constituents of avocado and soya in vivo. Drugs Exp.Clin.Res. 1998;24(1):41-50. View abstract.
Kut-Lasserre, C., Miller, C. C., Ejeil, A. L., Gogly, B., Dridi, M., Piccardi, N., Guillou, B., Pellat, B., and Godeau, G. Effect of avocado and soybean unsaponifiables on gelatinase A (MMP-2), stromelysin 1 (MMP-3), and tissue inhibitors of matrix metalloproteinase (. J.Periodontol. 2001;72(12):1685-1694. View abstract.
Kut-Lasserre, C., Miller, C. C., Ejeil, A. L., Gogly, B., Dridi, M., Piccardi, N., Guillou, B., Pellat, B., and Godeau, G. Effect of avocado and soybean unsaponifiables on gelatinase A (MMP-2), stromelysin 1 (MMP-3), and tissue inhibitors of matrix metalloproteinase (. J.Periodontol. 2001;72(12):1685-1694. View abstract.
Andriamanalijaona R, Benateau H, Barre PE, et al. Effect of interleukin-1beta on transforming growth factor-beta and bone morphogenetic protein-2 expression in human periodontal ligament and alveolar bone cells in culture: modulation by avocado and soybean unsaponifiables. J Periodontol. 2006;77(7):1156-66. View abstract.
Andriamanalijaona R, Benateau H, Barre PE, et al. Effect of interleukin-1beta on transforming growth factor-beta and bone morphogenetic protein-2 expression in human periodontal ligament and alveolar bone cells in culture: modulation by avocado and soybean unsaponifiables. J Periodontol. 2006;77(7):1156-66. View abstract.
Catunda IS, Vasconcelos BC, Andrade ES, Costa DF. Clinical effects of an avocado-soybean unsaponifiable extract on arthralgia and osteoarthritis of the temporomandibular joint: preliminary study. Int J Oral Maxillofac Surg. 2016;45(8):1015-22. View abstract.
Catunda IS, Vasconcelos BC, Andrade ES, Costa DF. Clinical effects of an avocado-soybean unsaponifiable extract on arthralgia and osteoarthritis of the temporomandibular joint: preliminary study. Int J Oral Maxillofac Surg. 2016;45(8):1015-22. View abstract.
Christensen R, Bartels EM, Astrup A, Bliddal H. Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials. Osteoarthritis Cartilage. 2008;16(4):399-408. View abstract.
Christensen R, Bartels EM, Astrup A, Bliddal H. Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials. Osteoarthritis Cartilage. 2008;16(4):399-408. View abstract.
Christiansen BA, Bhatti S, Goudarzi R, Emami S. Erratum: Response to the letter to the editor for "Management of osteoarthritis with avocado/soybean unsaponifiables". Cartilage. 2016;7(1):114-5. View abstract.
Christiansen BA, Bhatti S, Goudarzi R, Emami S. Erratum: Response to the letter to the editor for "Management of osteoarthritis with avocado/soybean unsaponifiables". Cartilage. 2016;7(1):114-5. View abstract.
Christiansen BA, Bhatti S, Goudarzi R, Emami S. Management of osteoarthritis with avocado/soybean unsaponifiables. Cartilage. 2015;6(1):30-44. View abstract.
Christiansen BA, Bhatti S, Goudarzi R, Emami S. Management of osteoarthritis with avocado/soybean unsaponifiables. Cartilage. 2015;6(1):30-44. View abstract.
Cornblatt BS. Letter to the editor for "Management of osteoarthritis with avocado/soybean unsaponifiables". Cartilage. 2016;7(1):112-3. View abstract.
Cornblatt BS. Letter to the editor for "Management of osteoarthritis with avocado/soybean unsaponifiables". Cartilage. 2016;7(1):112-3. View abstract.
Frondoza CG. Response to letter to editor entitled: "Avocado/soybean unsaponfiables, ASU Expanscience, are strictly different from the nutraceutical products claiming ASU appellation" (4365). Osteoarthritis Cartilage. 2008;16(12):1590-1. View abstract.
Frondoza CG. Response to letter to editor entitled: "Avocado/soybean unsaponfiables, ASU Expanscience, are strictly different from the nutraceutical products claiming ASU appellation" (4365). Osteoarthritis Cartilage. 2008;16(12):1590-1. View abstract.
Goudarzi R, Taylor JF, Yazdi PG, Pedersen BA. Effects of Arthrocen, an avocado/soy unsaponifiables agent, on inflammatory mediators and gene expression in human chondrocytes. FEBS Open Bio. 2017 Jan 9;7(2):187-194. View abstract.
Goudarzi R, Taylor JF, Yazdi PG, Pedersen BA. Effects of Arthrocen, an avocado/soy unsaponifiables agent, on inflammatory mediators and gene expression in human chondrocytes. FEBS Open Bio. 2017 Jan 9;7(2):187-194. View abstract.
Henrotin YE, Sanchez C, Deberg MA, et al. Avocado/soybean unsaponifiables increase aggrecan synthesis and reduce catabolic and proinflammatory mediator production by human osteoarthritic chondrocytes. J Rheumatol 2003;30:1825-34. View abstract.
Henrotin YE, Sanchez C, Deberg MA, et al. Avocado/soybean unsaponifiables increase aggrecan synthesis and reduce catabolic and proinflammatory mediator production by human osteoarthritic chondrocytes. J Rheumatol 2003;30:1825-34. View abstract.
Lequesne M, Maheu E, Cadet C, Dreiser RL. Structural effect of avocado/soybean unsaponifiables on joint space loss in osteoarthritis of the hip. Arthritis Rheum 2002;47:50-8.. View abstract.
Lequesne M, Maheu E, Cadet C, Dreiser RL. Structural effect of avocado/soybean unsaponifiables on joint space loss in osteoarthritis of the hip. Arthritis Rheum 2002;47:50-8.. View abstract.
Maheu E, Cadet C, Marty M, et al. Randomised, controlled trial of avocado-soybean unsaponifiable (Piascledine) effect on structure modification in hip osteoarthritis: the ERADIAS study. Ann Rheum Dis. 2014;73(2):376-84. View abstract.
Maheu E, Cadet C, Marty M, et al. Randomised, controlled trial of avocado-soybean unsaponifiable (Piascledine) effect on structure modification in hip osteoarthritis: the ERADIAS study. Ann Rheum Dis. 2014;73(2):376-84. View abstract.
Maheu E, Mazieres B, Valat JP, et al. Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six-month treatment period and a two-month followup demonstrating a persistent effect. Arthritis Rheum 1998;41:81-91. View abstract.
Maheu E, Mazieres B, Valat JP, et al. Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six-month treatment period and a two-month followup demonstrating a persistent effect. Arthritis Rheum 1998;41:81-91. View abstract.
Martínez-Abundis E, González-Ortiz M, Mercado-Sesma AR, Reynoso-von-Drateln C, Moreno-Andrade A. Effect of avocado soybean unsaponifiables on insulin secretion and insulin sensitivity in patients with obesity. Obes Facts. 2013;6(5):443-8. View abstract.
Martínez-Abundis E, González-Ortiz M, Mercado-Sesma AR, Reynoso-von-Drateln C, Moreno-Andrade A. Effect of avocado soybean unsaponifiables on insulin secretion and insulin sensitivity in patients with obesity. Obes Facts. 2013;6(5):443-8. View abstract.
Msika P, Baudouin C, Saunois A, Bauer T. Avocado/soybean unsaponifiables, ASU EXPANSCIENCE, are strictly different from the nutraceutical products claiming ASU appellation. Osteoarthritis Cartilage. 2008;16(10):1275-6. View abstract.
Msika P, Baudouin C, Saunois A, Bauer T. Avocado/soybean unsaponifiables, ASU EXPANSCIENCE, are strictly different from the nutraceutical products claiming ASU appellation. Osteoarthritis Cartilage. 2008;16(10):1275-6. View abstract.
Oliveira GJ, Paula LG, Souza JA, Spin-Neto R, Stavropoulos A, Marcantonio RA. Effect of avocado/soybean unsaponifiables on ligature-induced bone loss and bone repair after ligature removal in rats. J Periodontal Res. 2016;51(3):332-41. View abstract.
Oliveira GJ, Paula LG, Souza JA, Spin-Neto R, Stavropoulos A, Marcantonio RA. Effect of avocado/soybean unsaponifiables on ligature-induced bone loss and bone repair after ligature removal in rats. J Periodontal Res. 2016;51(3):332-41. View abstract.
Oryan A, Mohammadalipour A, Moshiri A, Tabandeh MR. Avocado/soybean unsaponifiables: a novel regulator of cutaneous wound healing, modelling and remodelling. Int Wound J. 2015;12(6):674-85. View abstract.
Oryan A, Mohammadalipour A, Moshiri A, Tabandeh MR. Avocado/soybean unsaponifiables: a novel regulator of cutaneous wound healing, modelling and remodelling. Int Wound J. 2015;12(6):674-85. View abstract.
Panahi Y, Beiraghdar F, Kashani N, Baharie Javan N, Dadjo Y. Comparison of piascledine (avocado and soybean oil) and hormone replacement therapy in menopausal-induced hot flashing. Iran J Pharm Res. 2011 Fall;10(4):941-51. View abstract.
Panahi Y, Beiraghdar F, Kashani N, Baharie Javan N, Dadjo Y. Comparison of piascledine (avocado and soybean oil) and hormone replacement therapy in menopausal-induced hot flashing. Iran J Pharm Res. 2011 Fall;10(4):941-51. View abstract.
Pavelka K, Coste P, Géher P, Krejci G. Efficacy and safety of piascledine 300 versus chondroitin sulfate in a 6 months treatment plus 2 months observation in patients with osteoarthritis of the knee. Clin Rheumatol. 2010;29(6):659-70. View abstract.
Pavelka K, Coste P, Géher P, Krejci G. Efficacy and safety of piascledine 300 versus chondroitin sulfate in a 6 months treatment plus 2 months observation in patients with osteoarthritis of the knee. Clin Rheumatol. 2010;29(6):659-70. View abstract.
Soliman MF. Evaluation of avocado/soybean unsaponifiable alone or concurrently with praziquantel in murine schistosomiasis. Acta Trop. 2012 Jun;122(3):261-6. View abstract.
Soliman MF. Evaluation of avocado/soybean unsaponifiable alone or concurrently with praziquantel in murine schistosomiasis. Acta Trop. 2012 Jun;122(3):261-6. View abstract.
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