AVOCADO SOY UNSAPONIFIABLES (ASU)

Appelboom, T., Schuermans, J., Verbruggen, G., Henrotin, Y., and Reginster, J. Y. Symptoms modifying effect of avocado/soybean unsaponifiables (ASU) in knee osteoarthritis. A double blind, prospective, placebo-controlled study. Scand J Rheumatol 2001;30(4):242-247. View abstract.

Blotman, F., Maheu, E., Wulwik, A., Caspard, H., and Lopez, A. Efficacy and safety of avocado/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip. A prospective, multicenter, three-month, randomized, double-blind, placebo-controlled trial. Rev Rhum Engl Ed 1997;64(12):825-834. View abstract.

Boumediene, K., Felisaz, N., Bogdanowicz, P., Galera, P., Guillou, G. B., and Pujol, J. P. Avocado/soya unsaponifiables enhance the expression of transforming growth factor beta1 and beta2 in cultured articular chondrocytes. Arthritis Rheum. 1999;42(1):148-156. View abstract.

Henrotin, Y. E., Labasse, A. H., Jaspar, J. M., De Groote, D. D., Zheng, S. X., Guillou, G. B., and Reginster, J. Y. Effects of three avocado/soybean unsaponifiable mixtures on metalloproteinases, cytokines and prostaglandin E2 production by human articular chondrocytes. Clin.Rheumatol. 1998;17(1):31-39. View abstract.

Khayyal, M. T. and el Ghazaly, M. A. The possible "chondroprotective" effect of the unsaponifiable constituents of avocado and soya in vivo. Drugs Exp.Clin.Res. 1998;24(1):41-50. View abstract.

Kut-Lasserre, C., Miller, C. C., Ejeil, A. L., Gogly, B., Dridi, M., Piccardi, N., Guillou, B., Pellat, B., and Godeau, G. Effect of avocado and soybean unsaponifiables on gelatinase A (MMP-2), stromelysin 1 (MMP-3), and tissue inhibitors of matrix metalloproteinase (. J.Periodontol. 2001;72(12):1685-1694. View abstract.

Andriamanalijaona R, Benateau H, Barre PE, et al. Effect of interleukin-1beta on transforming growth factor-beta and bone morphogenetic protein-2 expression in human periodontal ligament and alveolar bone cells in culture: modulation by avocado and soybean unsaponifiables. J Periodontol. 2006;77(7):1156-66. View abstract.

Catunda IS, Vasconcelos BC, Andrade ES, Costa DF. Clinical effects of an avocado-soybean unsaponifiable extract on arthralgia and osteoarthritis of the temporomandibular joint: preliminary study. Int J Oral Maxillofac Surg. 2016;45(8):1015-22. View abstract.

Christensen R, Bartels EM, Astrup A, Bliddal H. Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials. Osteoarthritis Cartilage. 2008;16(4):399-408. View abstract.

Christiansen BA, Bhatti S, Goudarzi R, Emami S. Erratum: Response to the letter to the editor for "Management of osteoarthritis with avocado/soybean unsaponifiables". Cartilage. 2016;7(1):114-5. View abstract.

Christiansen BA, Bhatti S, Goudarzi R, Emami S. Management of osteoarthritis with avocado/soybean unsaponifiables. Cartilage. 2015;6(1):30-44. View abstract.

Cornblatt BS. Letter to the editor for "Management of osteoarthritis with avocado/soybean unsaponifiables". Cartilage. 2016;7(1):112-3. View abstract.

Frondoza CG. Response to letter to editor entitled: "Avocado/soybean unsaponfiables, ASU Expanscience, are strictly different from the nutraceutical products claiming ASU appellation" (4365). Osteoarthritis Cartilage. 2008;16(12):1590-1. View abstract.

Goudarzi R, Taylor JF, Yazdi PG, Pedersen BA. Effects of Arthrocen, an avocado/soy unsaponifiables agent, on inflammatory mediators and gene expression in human chondrocytes. FEBS Open Bio. 2017 Jan 9;7(2):187-194. View abstract.

Henrotin YE, Sanchez C, Deberg MA, et al. Avocado/soybean unsaponifiables increase aggrecan synthesis and reduce catabolic and proinflammatory mediator production by human osteoarthritic chondrocytes. J Rheumatol 2003;30:1825-34. View abstract.

Lequesne M, Maheu E, Cadet C, Dreiser RL. Structural effect of avocado/soybean unsaponifiables on joint space loss in osteoarthritis of the hip. Arthritis Rheum 2002;47:50-8.. View abstract.

Maheu E, Cadet C, Marty M, et al. Randomised, controlled trial of avocado-soybean unsaponifiable (Piascledine) effect on structure modification in hip osteoarthritis: the ERADIAS study. Ann Rheum Dis. 2014;73(2):376-84. View abstract.

Maheu E, Mazieres B, Valat JP, et al. Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip: a prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with a six-month treatment period and a two-month followup demonstrating a persistent effect. Arthritis Rheum 1998;41:81-91. View abstract.

Martínez-Abundis E, González-Ortiz M, Mercado-Sesma AR, Reynoso-von-Drateln C, Moreno-Andrade A. Effect of avocado soybean unsaponifiables on insulin secretion and insulin sensitivity in patients with obesity. Obes Facts. 2013;6(5):443-8. View abstract.

Msika P, Baudouin C, Saunois A, Bauer T. Avocado/soybean unsaponifiables, ASU EXPANSCIENCE, are strictly different from the nutraceutical products claiming ASU appellation. Osteoarthritis Cartilage. 2008;16(10):1275-6. View abstract.

Oliveira GJ, Paula LG, Souza JA, Spin-Neto R, Stavropoulos A, Marcantonio RA. Effect of avocado/soybean unsaponifiables on ligature-induced bone loss and bone repair after ligature removal in rats. J Periodontal Res. 2016;51(3):332-41. View abstract.

Oryan A, Mohammadalipour A, Moshiri A, Tabandeh MR. Avocado/soybean unsaponifiables: a novel regulator of cutaneous wound healing, modelling and remodelling. Int Wound J. 2015;12(6):674-85. View abstract.

Panahi Y, Beiraghdar F, Kashani N, Baharie Javan N, Dadjo Y. Comparison of piascledine (avocado and soybean oil) and hormone replacement therapy in menopausal-induced hot flashing. Iran J Pharm Res. 2011 Fall;10(4):941-51. View abstract.

Pavelka K, Coste P, Géher P, Krejci G. Efficacy and safety of piascledine 300 versus chondroitin sulfate in a 6 months treatment plus 2 months observation in patients with osteoarthritis of the knee. Clin Rheumatol. 2010;29(6):659-70. View abstract.

Soliman MF. Evaluation of avocado/soybean unsaponifiable alone or concurrently with praziquantel in murine schistosomiasis. Acta Trop. 2012 Jun;122(3):261-6. View abstract.