TETRAHYDROCANNABIVARIN (THCV)

OTHER NAME(S):

(6aR,10aR)-6,6,9-trimethyl-3-propyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-ol, THC-V, THCV, THV, GWP42004.

Overview

Overview Information

Tetrahydrocannabivarin is a chemical in the cannabis plant. It is similar to the chemical tetrahydrocannabinol (THC). But it doesn't affect thinking like THC.

Tetrahydrocannabivarin is used for diabetes, pain, swelling (inflammation), seizures, and other conditions, but there is no good scientific evidence to support these uses.

How does it work?

Tetrahydrocannabivarin seems to affect certain nerve cells in the brain. These effects might reduce seizures, regulate emotional reactions to food, reduce cravings for addictive substances, and have other effects.
Uses

Uses & Effectiveness?

Insufficient Evidence for

More evidence is needed to rate the effectiveness of tetrahydrocannabivarin for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Tetrahydrocannabivarin is POSSIBLY SAFE for adults when used for up to 13 weeks. Side effects have not been reported in clinical research.

Special Precautions & Warnings:

Pregnancy and breast-feeding:There isn't enough reliable information to know if tetrahydrocannabivarin is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Interactions

Interactions?

We currently have no information for TETRAHYDROCANNABIVARIN (THCV) Interactions.

Dosing

Dosing

The appropriate dose of tetrahydrocannabivarin depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for tetrahydrocannabivarin. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • 97021 Jadoon KA, Ratcliffe SH, Barrett DA, et al. Efficacy and safety of cannabidiol and tetrahydrocannabivarin on glycemic and lipid parameters in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel group pilot study. Diabetes Care. 2016 Oct;39(10):1777-86. View abstract.
  • Bolognini D, Costa B, Maione S, et al. The plant cannabinoid Delta9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice. Br J Pharmacol. 2010;160(3):677-87. View abstract.
  • Cascio MG, Zamberletti E, Marini P, Parolaro D, Pertwee RG. The phytocannabinoid, ??-tetrahydrocannabivarin, can act through 5-HT1A receptors to produce antipsychotic effects. Br J Pharmacol. 2015;172(5):1305-18. View abstract.
  • Deiana S, Watanabe A, Yamasaki Y, et al. Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), ??-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsive behaviour. Psychopharmacology (Berl). 2012;219(3):859-73. View abstract.
  • Englund A, Atakan Z, Kralj A, Tunstall N, Murray R, Morrison P. The effect of five day dosing with THCV on THC-induced cognitive, psychological and physiological effects in healthy male human volunteers: A placebo-controlled, double-blind, crossover pilot trial. J Psychopharmacol. 2016;30(2):140-51. View abstract.
  • Hill AJ, Weston SE, Jones NA, et al. ??-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats. Epilepsia. 2010;51(8):1522-32. View abstract.
  • Pagano E, Montanaro V, Di Girolamo A, et al. Effect of Non-psychotropic Plant-derived Cannabinoids on Bladder Contractility: Focus on Cannabigerol. Nat Prod Commun. 2015;10(6):1009-12. View abstract.
  • Rock EM, Sticht MA, Duncan M, Stott C, Parker LA. Evaluation of the potential of the phytocannabinoids, cannabidivarin (CBDV) and ?(9) -tetrahydrocannabivarin (THCV), to produce CB1 receptor inverse agonism symptoms of nausea in rats. Br J Pharmacol. 2013;170(3):671-8. View abstract.
  • Romano B, Pagano E, Orlando P, et al. Pure ?9-tetrahydrocannabivarin and a Cannabis sativa extract with high content in ?9-tetrahydrocannabivarin inhibit nitrite production in murine peritoneal macrophages. Pharmacol Res. 2016;113(Pt A):199-208. View abstract.
  • Rzepa E, Tudge L, McCabe C. The CB1 Neutral Antagonist Tetrahydrocannabivarin Reduces Default Mode Network and Increases Executive Control Network Resting State Functional Connectivity in Healthy Volunteers. Int J Neuropsychopharmacol. 2015;19(2). pii: pyv092. View abstract.
  • Tudge L, Williams C, Cowen PJ, McCabe C. Neural effects of cannabinoid CB1 neutral antagonist tetrahydrocannabivarin on food reward and aversion in healthy volunteers. Int J Neuropsychopharmacol. 2014;18(6). pii: pyu094. View abstract.
  • Wargent ET, Zaibi MS, Silvestri C, et al. The cannabinoid ?(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity. Nutr Diabetes. 2013;3:e68. View abstract.
  • Xi ZX, Muldoon P, Wang XF, et al. ?8 -Tetrahydrocannabivarin has potent anti-nicotine effects in several rodent models of nicotine dependence. Br J Pharmacol. 2019. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.