Delta-9-tetrahydrocannabinol (THC) is a cannabinoid found in cannabis (Cannabis sativa). The psychoactive effects of cannabis are mainly due to THC.

There are over 80 cannabinoids in Cannabis sativa, but THC and cannabidiol (CBD) are the most well-studied. THC works by binding to specific sites in the brain and on the nerves. It's found in the highest levels in the leaves and flowers of the plant.

THC is commonly used as a recreational drug. People also use THC for multiple sclerosis (MS), nerve pain, nausea and vomiting from chemotherapy, alcohol use disorder, and many other conditions, but there is no good scientific evidence to support these uses. There is also no good evidence to support using THC for COVID-19.

Don't confuse THC with other cannabinoids found in cannabis, including cannabichromene (CBC), cannabidiol (CBD), cannabidivarin (CBDV), cannabigerol (CBG), cannabinol (CBN), delta-8-tetrahydrocannabinol (Delta-8-THC), or tetrahydrocannabivarin (THCV). Also don't confuse it with synthetic cannabinoids such as K2/Spice, or with plants containing THC, such as cannabis or hemp. These are not the same. THC is illegal on the federal level in the US. Due to its THC content, cannabis is classified as a Schedule I controlled substance. But some states have legalized or decriminalized recreational use.

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