Common Sage, Dalmatian Sage, Feuille de la Bergère, Garden Sage, Herbe Sacré, Meadow Sage, Salvia lavandulaefolia, Salvia officinalis, Sauge, Sauge Ananas, Sauge des Prairies, Sauge Divinatoire, Sauge Divine, Sauge Domestique, Sauge Officinale, Scarlet Sage, Spanish Sage, True Sage, Vraie Sauge.<br/><br/>
Overview InformationSage is an herb. The leaf is used to make medicine. There are many species of sage. The two most common species are common sage (Salvia officinalis) and Spanish sage (Salvia lavandulaefolia).
Sage is used for digestive problems, including loss of appetite, gas (flatulence), stomach pain (gastritis), diarrhea, bloating, and heartburn. It is also used for reducing overproduction of perspiration and saliva; and for depression, diabetes, high cholesterol, and a condition in which there is too little blood flow to the brain (cerebral ischemia). It is also used to improve mental performance and memory, to reduce pain after surgery, for Alzheimer's disease, and to prevent lung cancer.
Women use sage for painful menstrual periods, to correct excessive milk flow during nursing, and to reduce hot flashes during menopause. Sage is also used by men to reduce hot flashes during certain treatment for prostate cancer called androgen deprivation therapy.
Sage is applied directly to the mouth or throat for cold sores, gum disease (gingivitis), sore mouth, throat, or tongue, swollen, painful nasal passages, and swollen tonsils. It is also applied to the skin after sun exposure to prevent sunburn.
Some people inhale sage for asthma. As an aromatherapy, some people use sage to improve memory and brain function.
In foods, sage is a commonly used spice.
In manufacturing, sage is used as a fragrance component in soaps and cosmetics.
How does it work?Sage might help with chemical imbalances in the brain that cause symptoms of Alzheimer's disease. It might also improve how the body uses insulin and sugar.
Uses & Effectiveness
Possibly Effective for
- Alzheimer's disease. Taking extracts of two different sage species, common sage and Spanish sage, for 4 months seems to improve learning, memory and information processing in people with mild to moderate Alzheimer's disease.
- Mental performance. Taking a single dose of common sage extract or Spanish sage essential oil by mouth seems to improve memory, alertness, and attention in healthy adults. When the essential oils of these sage species are used as aromatherapy, it seems to improve alertness, but not attention and memory.
- Diabetes. Taking common sage leaf extract three times daily for 3 months lowers fasting blood sugar and average blood sugar over time (HbA1c) in diabetes patients.
- High cholesterol. Taking common sage three times daily for 2 or 3 months reduces "bad" low-density lipoprotein (LDL) cholesterol and blood fats called triglycerides, and increases "good" high-density lipoprotein (HDL) cholesterol, in people with high cholesterol or high triglycerides.
- Memory. Taking a single dose of common sage extract or Spanish sage essential oil by mouth seems to improve memory in healthy adults. However, these sage species do not seem to improve memory when used as aromatherapy.
Possibly Ineffective for
- Pain after surgery. Early research shows that using an oral rinse made of common sage along with pain medications is less effective for reducing pain after surgery compared to using the drug benzydamine hydrochloride. Also, using a mouth rinse containing common sage seems to increase the risk for infection after surgery.
Insufficient Evidence for
- Hot flashes in men due to prostate cancer treatment. Early research shows that taking common sage extract three times daily for 4 weeks reduces the severity and frequency of hot flashes in prostate cancer patients who are being treated with androgen deprivation.
- Cold sores. Applying a cream containing common sage and rhubarb to cold sores may be about as effective as acyclovir (Zovirax) cream. Acyclovir cream heals the cold sores in about 6 days. It takes the sage and rhubarb cream about 7 days to heal them. Sage and rhubarb together work faster than a cream containing only sage.
- Lung cancer. People who regularly use sage as a spice seem to have a 54% lower chance of developing lung cancer compared to those who don't use sage as a spice.
- Menopausal symptoms. Early research shows that taking common sage extract (Sage Menopause, Bioforce AG) for 8 weeks improves symptoms of menopause, especially hot flashes.
- Sore throat. Using a specific spray (Valverde Salvia Rachenspray) containing common sage extract 15% reduces throat pain in people with a sore throat. However, sprays containing higher (30%) and lower (5%) amounts of common sage extract do not seem to reduce throat pain. Other early research shows that using a throat spray containing common sage and echinacea for up to 5 days improves sore throat symptoms similarly to a common sore throat drug spray.
- Sunburn. Applying an ointment containing common sage extract to the skin after exposure to UV light seems to reduce the development of skin redness.
- Swelling of the tonsils (tonsillitis). Early research shows that using a throat spray containing common sage and echinacea for up to 5 days improves symptoms of tonsillitis similarly to a commonly used drug.
- Loss of appetite.
- Stomach pain.
- Dry mouth.
- Painful periods.
- Excessive sweating.
- Other condition.
Side Effects & SafetySage is LIKELY SAFE in amounts typically used in foods. It is POSSIBLY SAFE when taken by mouth or applied to the skin in medicinal amounts, for up to 4 months.
However, sage is POSSIBLY UNSAFE when taken by mouth in high doses or for a long time. Some species of sage, such as common sage (Salvia officinalis), contain a chemical called thujone. Thujone can be poisonous if you take too much. This chemical can cause seizures and damage the liver and nervous system. The amount of thujone varies with the species of sage, the time of harvest, growing conditions, and other factors.
Special Precautions & Warnings:Pregnancy and breast-feeding: Taking sage during pregnancy is LIKELY UNSAFE because of the possibility of consuming thujone, a chemical found in some sage. Thujone can bring on a woman's menstrual period, and this could cause a miscarriage. Avoid sage if you are breast-feeding, too. There is some evidence that thujone might reduce the supply of mother's milk.
Diabetes: Sage might lower blood sugar levels in people with diabetes. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use sage. The dose of your diabetes medications may need to be adjusted by your healthcare provider.
Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Spanish sage (Salvia lavandulaefolia) might have the same effects as the female hormone estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use Spanish sage.
High blood pressure, low blood pressure: Spanish sage (Salvia lavandulaefolia) might increase blood pressure in some people with high blood pressure. On the other hand, common sage (Salvia officinalis) might lower blood pressure in people with blood pressure that is already low. Be sure to monitor your blood pressure.
Seizure disorders: One species of sage (Salvia officinalis) contains significant amounts of thujone, a chemical that can trigger seizures. If you have a seizure disorder, don't take sage in amounts higher than those typically found in food.
Surgery: Common sage might affect blood sugar levels. There is a concern that it might interfere with blood sugar control during and after surgery. Stop using common sage as a medicine at least 2 weeks before a scheduled surgery.
Be cautious with this combination
Medications for diabetes (Antidiabetes drugs) interacts with SAGE
Sage might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking sage along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.<br/><br/> Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Medications used to prevent seizures (Anticonvulsants) interacts with SAGE
Medications used to prevent seizures affect chemicals in the brain. Sage may also affect chemicals in the brain. By affecting chemicals in the brain, sage may decrease the effectiveness of medications used to prevent seizures.<br/><br/> Some medications used to prevent seizures include phenobarbital, primidone (Mysoline), valproic acid (Depakene), gabapentin (Neurontin), carbamazepine (Tegretol), phenytoin (Dilantin), and others.
Sedative medications (CNS depressants) interacts with SAGE
Sage might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking sage along with sedative medications might cause too much sleepiness.<br/><br/> Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.
The following doses have been studied in scientific research:
- For treating Alzheimer's disease: 1 gram of sage per day. A dose of sage extract, gradually increased over time to 2.5 mg three times daily, has also been used.
- For improving mental performance or memory: 25-50 mcL of Spanish sage essential oil or 333 mg of common sage extract have been taken as a single dose before mental tests.
- For diabetes: 500 mg of common sage extract has been used three times per day for 3 months.
- For high cholesterol: 500 mg of common sage extract has been used three times per day for 2 or 3 months.
- Pavela, R. Insecticidal activity of certain medicinal plants. Fitoterapia 2004;75(7-8):745-749. View abstract.
- Pavlenko, L. V., Mashkovskii, N. N., and Smirnov, V. V. [Effect of salvin on the incorporation of labeled precursors into macromolecular compounds of Staphylococcus aureus 209P]. Antibiot.Khimioter. 1989;34(8):582-585. View abstract.
- Pavlenko, L. V., Stepaniuk, V. V., Volosovets, P. S., and Smirnov, V. V. [The effect of salvin on the growth and ultrastructure of Staphylococcus aureus 209P]. Mikrobiol.Zh. 1989;51(2):86-91. View abstract.
- Pereira, P., Tysca, D., Oliveira, P., da Silva Brum, L. F., Picada, J. N., and Ardenghi, P. Neurobehavioral and genotoxic aspects of rosmarinic acid. Pharmacol.Res. 2005;52(3):199-203. View abstract.
- Perry, E. and Howes, M. J. Medicinal plants and dementia therapy: herbal hopes for brain aging? CNS.Neurosci.Ther 2011;17(6):683-698. View abstract.
- Perry, E. K., Pickering, A. T., Wang, W. W., Houghton, P. J., and Perry, N. S. Medicinal plants and Alzheimer's disease: from ethnobotany to phytotherapy. J Pharm Pharmacol 1999;51(5):527-534. View abstract.
- Perry, E. K., Pickering, A. T., Wang, W. W., Houghton, P., and Perry, N. S. Medicinal plants and Alzheimer's disease: Integrating ethnobotanical and contemporary scientific evidence. J Altern Complement Med 1998;4(4):419-428. View abstract.
- Perry, N. S., Houghton, P. J., Sampson, J., Theobald, A. E., Hart, S., Lis-Balchin, M., Hoult, J. R., Evans, P., Jenner, P., Milligan, S., and Perry, E. K. In-vitro activity of S. lavandulaefolia (Spanish sage) relevant to treatment of Alzheimer's disease. J Pharm Pharmacol 2001;53(10):1347-1356. View abstract.
- Perry, N. S., Houghton, P. J., Theobald, A., Jenner, P., and Perry, E. K. In-vitro inhibition of human erythrocyte acetylcholinesterase by salvia lavandulaefolia essential oil and constituent terpenes. J Pharm Pharmacol 2000;52(7):895-902. View abstract.
- Perry, N., Court, G., Bidet, N., Court, J., and Perry, E. European herbs with cholinergic activities: Potential in dementia. Int J Ger Psych 1996;11(12):1063-1069.
- Pitten, F. A. and Kramer, A. Antimicrobial efficacy of antiseptic mouthrinse solutions. Eur J Clin Pharmacol 1999;55(2):95-100. View abstract.
- Poeckel, D., Greiner, C., Verhoff, M., Rau, O., Tausch, L., Hornig, C., Steinhilber, D., Schubert-Zsilavecz, M., and Werz, O. Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes. Biochem.Pharmacol 7-1-2008;76(1):91-97. View abstract.
- Radtke, O. A., Foo, L. Y., Lu, Y., Kiderlen, A. F., and Kolodziej, H. Evaluation of sage phenolics for their antileishmanial activity and modulatory effects on interleukin-6, interferon and tumour necrosis factor-alpha-release in RAW 264.7 cells. Z.Naturforsch.[C.] 2003;58(5-6):395-400. View abstract.
- Rau, O., Wurglics, M., Paulke, A., Zitzkowski, J., Meindl, N., Bock, A., Dingermann, T., Abdel-Tawab, M., and Schubert-Zsilavecz, M. Carnosic Acid and Carnosol, Phenolic Diterpene Compounds of the Labiate Herbs Rosemary and Sage, are Activators of the Human Peroxisome Proliferator-Activated Receptor Gamma. Planta Med 2006;72(10):881-887. View abstract.
- Renzulli, C., Galvano, F., Pierdomenico, L., Speroni, E., and Guerra, M. C. Effects of rosmarinic acid against aflatoxin B1 and ochratoxin-A-induced cell damage in a human hepatoma cell line (Hep G2). J Appl Toxicol 2004;24(4):289-296. View abstract.
- Reuter, J., Jocher, A., Hornstein, S., Monting, J. S., and Schempp, C. M. Sage extract rich in phenolic diterpenes inhibits ultraviolet-induced erythema in vivo. Planta Med 2007;73(11):1190-1191. View abstract.
- Sa, C. M., Ramos, A. A., Azevedo, M. F., Lima, C. F., Fernandes-Ferreira, M., and Pereira-Wilson, C. Sage tea drinking improves lipid profile and antioxidant defences in humans. Int J Mol.Sci. 2009;10(9):3937-3950. View abstract.
- Santos-Gomes, P. C. and Fernandes-Ferreira, M. Organ- and season-dependent variation in the essential oil composition of Salvia officinalis L. cultivated at two different sites. J Agric.Food Chem. 2001;49(6):2908-2916. View abstract.
- Savelev, S. U., Okello, E. J., and Perry, E. K. Butyryl- and acetyl-cholinesterase inhibitory activities in essential oils of Salvia species and their constituents. Phytother Res 2004;18(4):315-324. View abstract.
- Savelev, S., Okello, E., Perry, N. S. L., Wilkins, R. M., and Perry, E. K. Synergistic and antagonistic interactions of anticholinesterase terpenoids in Salvia lavandulaefolia essential oil. Pharmacol Biochem Behav 2003;75(3):661-668.
- Schafer, R. and Schafer, W. Percutaneous absorption of various terpenes - menthol, camphene, limonene, isoborneol-acetate and alpha-pinene from foam baths. Arzneim Forsch 1982;32(1):56-58.
- Schimmer, O., Kruger, A., Paulini, H., and Haefele, F. An evaluation of 55 commercial plant extracts in the Ames mutagenicity text. Pharmazie 1994;49:448-451.
- Schnitzler, P., Nolkemper, S., Stintzing, F. C., and Reichling, J. Comparative in vitro study on the anti-herpetic effect of phytochemically characterized aqueous and ethanolic extracts of Salvia officinalis grown at two different locations. Phytomedicine. 2008;15(1-2):62-70. View abstract.
- Scholey, A. B., Tildesley, N. T., Ballard, C. G., Wesnes, K. A., Tasker, A., Perry, E. K., and Kennedy, D. O. An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers. Psychopharmacology (Berl) 2008;198(1):127-139. View abstract.
- Sertoli, A., Fabbri, P., Campolmi, P., and Panconesi, E. Allergic contact dermatitis to Salvia Officinalis, Inula Viscosa and Conyza Bonariensis. Contact Dermatitis 1978;4(5):314-315.
- Sterer, N., Nuas, S., Mizrahi, B., Goldenberg, C., Weiss, E. I., Domb, A., and Davidi, M. P. Oral malodor reduction by a palatal mucoadhesive tablet containing herbal formulation. J Dent. 2008;36(7):535-539. View abstract.
- Tildesley, N. T., Kennedy, D. O., Perry, E. K., Ballard, C. G., Wesnes, K. A., and Scholey, A. B. Positive modulation of mood and cognitive performance following administration of acute doses of Salvia lavandulaefolia essential oil to healthy young volunteers. Physiol Behav. 1-17-2005;83(5):699-709. View abstract.
- von Skramlik, E. Uber die Giftigkeit und Vertraglichkeit von atherischen Olen. Pharmazie 1959;14:435-445.
- Vujosevic, M. and Blagojevic, J. Antimutagenic effects of extracts from sage (Salvia officinalis) in mammalian system in vivo. Acta Vet.Hung. 2004;52(4):439-443. View abstract.
- Vukovic-Gacic, B., Simic, D., Knezevic-Vukcevic, J., and Djarmati, Z. Antimutagenic effect of sage (Salvia officinalis L.). Arhiv za Farmaciju 1993;43:257-263.
- Wake, G., Court, J., Pickering, A., Lewis, R., Wilkins, R., and Perry, E. CNS acetylcholine receptor activity in European medicinal plants traditionally used to improve failing memory. J Ethnopharmacol 2000;69(2):105-114. View abstract.
- Wu, T. Y., Chen, C. P., and Jinn, T. R. Traditional Chinese medicines and Alzheimer's disease. Taiwan.J.Obstet.Gynecol. 2011;50(2):131-135. View abstract.
- Xavier, C. P., Lima, C. F., Fernandes-Ferreira, M., and Pereira-Wilson, C. Salvia fruticosa, Salvia officinalis, and rosmarinic acid induce apoptosis and inhibit proliferation of human colorectal cell lines: the role in MAPK/ERK pathway. Nutr Cancer 2009;61(4):564-571. View abstract.
- Yu, Y. M., Lin, H. C., and Chang, W. C. Carnosic acid prevents the migration of human aortic smooth muscle cells by inhibiting the activation and expression of matrix metalloproteinase-9. Br.J Nutr 2008;100(4):731-738. View abstract.
- Zani, F., Massimo, G., Benvenuti, S., Bianchi, A., Albasini, A., Melegari, M., Vampa, G., Bellotti, A., and Mazza, P. Studies on the genotoxic properties of essential oils with Bacillus subtilis rec-assay and Salmonella/microsome reversion assay. Planta Med 1991;57(3):237-241. View abstract.
- Zuskin, E. and Skuric, Z. Respiratory function in tea workers. Br J Ind Med 1984;41(1):88-93. View abstract.
- Zuskin, E., Kanceljak, B., Skuric, Z., and Ivankovic, D. Immunological and respiratory changes in tea workers. Int Arch Occup.Environ.Health 1985;56(1):57-65. View abstract.
- Zuskin, E., Kanceljak, B., Witek, T. J., Jr., and Schachter, E. N. Acute effects of herbal tea dust extracts on lung function. Chest 1989;96(6):1327-1331. View abstract.
- Akhondzadeh S, Noroozian M, Mohammadi M, et al. Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomized and placebo-controlled trial. J Clin Pharm Ther 2003;28:53-9. View abstract.
- Alarcon-Aguilar FJ, Roman-Ramos R, Flores-Saenz JL, Aguirre-Garcia F. Investigation on the hypoglycaemic effects of extracts of four Mexican medicinal plants in normal and alloxan-diabetic mice. Phytother Res. 2002;16(4):383-6. View abstract.
- Bommer S, Klein P, Suter A. First time proof of sage's tolerability and efficacy in menopausal women with hot flushes. Adv Ther 2011;28:490-500. View abstract.
- Broadhurst CL, Polansky MM, Anderson RA. Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro. J Agric Food Chem 2000;48:849-52.. View abstract.
- Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. View abstract.
- Buto SK, Tsang TK, Sielaff GW, et al. Bay leaf impaction in the esophagus and hypopharynx. Ann Intern Med 1990;113:82-3.
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Foster BC, Vandenhoek S, Hana J, et al. In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products. Phytomedicine 2003;10:334-42.. View abstract.
- Hamidpour M, Hamidpour R, Hamidpour S, Shahlari M. Chemistry, Pharmacology, and Medicinal Property of Sage (Salvia) to Prevent and Cure Illnesses such as Obesity, Diabetes, Depression, Dementia, Lupus, Autism, Heart Disease, and Cancer. J Tradit Complement Med. 2014;4(2):82-8. View abstract.
- Kianbakht S, Dabaghian FH. Improved glycemic control and lipid profile in hyperlipidemic type 2 diabetic patients consuming Salvia officinalis L. leaf extract: a randomized placebo. Controlled clinical trial. Complement Ther Med. 2013;21(5):441-6. View abstract.
- Leatherdale B, Panesar RK, Singh G, et al. Improvement in glucose tolerance due to Momordica charantia. Br Med J (Clin Res Ed) 1981;282:1823-4. View abstract.
- Millet Y, Jouglard J, Steinmetz MD, et al. Toxicity of some essential plant oils. Clinical and experimental study. Clin Toxicol 1981;18:1485-98. View abstract.
- Miroddi M, Navarra M, Quattropani MC, et al. Systematic review of clinical trials assessing pharmacological properties of Salvia species on memory, cognitive impairment and Alzheimer's disease. CNS Neurosci Ther. 2014;20(6):485-95. View abstract.
- Perry NB, Anderson RE, Brennan NJ, et al. Essential oils from dalmatian sage (Salvia officinalis l.): variations among individuals, plant parts, seasons, and sites. J Agric Food Chem 1999;47:2048-54.. View abstract.
- Perry NS, Bollen C, Perry EK, Ballard C. Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial. Pharmacol Biochem Behav 2003;75:651-9.. View abstract.
- Pierre F, et al. Short-chain fructo-oligosaccharides reduced the occurrence of colon tumors and develop gut-associated lymphoid tissue in Min mice. Cancer Res 1997;57:225-8. View abstract.
- Saller R, Buechi S, Meyrat R, Schmidhauser C. Combined herbal preparation for topical treatment of Herpes labialis. Forsch Komplementarmed Klass Naturheilkd 2001;8:373-82. View abstract.
- Schapowal A, Berger D, Klein P, et al. Echinacea/sage or chlorhexidine/lidocaine for treating acute sore throats: a randomized double-blind trial. Eur.J Med Res 9-1-2009;14:406-12. View abstract.
- Tildesley NT, Kennedy DO, Perry EK, et al. Salvia lavandulaefolia (Spanish Sage) enhances memory in healthy young volunteers. Pharmacol Biochem Behav 2003;75:669-74.. View abstract.
- Todorov S, Philianos S, Petkov V, et al. Experimental pharmacological study of three species from genus Salvia. Acta Physiol Pharmacol (Bulg) 1984;10:13-20. View abstract.
- Vandecasteele K, Ost P, Oosterlinck W, et al. Evaluation of the efficacy and safety of Salvia officinalis in controlling hot flashes in prostate cancer patients treated with androgen deprivation. Phytother Res. 2012;26(2):208-13. View abstract.
- O'Mahony, R., Al Khtheeri, H., Weerasekera, D., Fernando, N., Vaira, D., Holton, J., and Basset, C. Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori. World J Gastroenterol. 12-21-2005;11(47):7499-7507. View abstract.
- Oboh, G. and Henle, T. Antioxidant and inhibitory effects of aqueous extracts of Salvia officinalis leaves on pro-oxidant-induced lipid peroxidation in brain and liver in vitro. J Med Food 2009;12(1):77-84. View abstract.
- Oniga, I., Parvu, A. E., Toiu, A., and Benedec, D. Effects of Salvia officinalis L. extract on experimental acute inflammation. Rev.Med Chir Soc.Med Nat.Iasi 2007;111(1):290-294. View abstract.
- Orhan, I. and Aslan, M. Appraisal of scopolamine-induced antiamnesic effect in mice and in vitro antiacetylcholinesterase and antioxidant activities of some traditionally used Lamiaceae plants. J.Ethnopharmacol. 3-18-2009;122(2):327-332. View abstract.
- Orhan, I., Kartal, M., Kan, Y., and Sener, B. Activity of essential oils and individual components against acetyl- and butyrylcholinesterase. Z.Naturforsch.C. 2008;63(7-8):547-553. View abstract.
- Osawa, K., Matsumoto, T., Yasuda, H., Kato, T., Naito, Y., and Okuda, K. The inhibitory effect of plant extracts on the collagenolytic activity and cytotoxicity of human gingival fibroblasts by Porphyromonas gingivalis crude enzyme. Bull.Tokyo Dent Coll. 1991;32(1):1-7. View abstract.
- Kavvadias, D., Monschein, V., Sand, P., Riederer, P., and Schreier, P. Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor. Planta Med. 2003;69(2):113-117. View abstract.
- Kennedy, D. O., Dodd, F. L., Robertson, B. C., Okello, E. J., Reay, J. L., Scholey, A. B., and Haskell, C. F. Monoterpenoid extract of sage (Salvia lavandulaefolia) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults. J.Psychopharmacol. 2011;25(8):1088-1100. View abstract.
- Kennedy, D. O., Pace, S., Haskell, C., Okello, E. J., Milne, A., and Scholey, A. B. Effects of cholinesterase inhibiting sage (Salvia officinalis) on mood, anxiety and performance on a psychological stressor battery. Neuropsychopharmacology 2006;31(4):845-852. View abstract.
- Kianbakht, S., Abasi, B., Perham, M., and Hashem, Dabaghian F. Antihyperlipidemic effects of Salvia officinalis L. leaf extract in patients with hyperlipidemia: a randomized double-blind placebo-controlled clinical trial. Phytother.Res. 2011;25(12):1849-1853. View abstract.
- Konishi, Y., Hitomi, Y., Yoshida, M., and Yoshioka, E. Pharmacokinetic study of caffeic and rosmarinic acids in rats after oral administration. J Agric Food Chem 6-15-2005;53(12):4740-4746. View abstract.
- Kwon, Y. I., Vattem, D. A., and Shetty, K. Evaluation of clonal herbs of Lamiaceae species for management of diabetes and hypertension. Asia Pac.J Clin Nutr 2006;15(1):107-118. View abstract.
- Lalicevic, S. and Djordjevic, I. Comparison of benzydamine hydrochloride and Salvia officinalis as an adjuvant local treatment to systemic nonsteroidal anti-inflammatory drug in controlling pain after tonsillectomy, adenoidectomy, or both: An open-label, single-blind, randomized clinical trial. Current Therapeutic Research, Clinical and Experimental 2004;65:360-372.
- Lima, C. F., Andrade, P. B., Seabra, R. M., Fernandes-Ferreira, M., and Pereira-Wilson, C. The drinking of a Salvia officinalis infusion improves liver antioxidant status in mice and rats. J Ethnopharmacol. 2-28-2005;97(2):383-389. View abstract.
- Lima, C. F., Azevedo, M. F., Araujo, R., Fernandes-Ferreira, M., and Pereira-Wilson, C. Metformin-like effect of Salvia officinalis (common sage): is it useful in diabetes prevention? Br.J Nutr 2006;96(2):326-333. View abstract.
- Lima, C. F., Fernandes-Ferreira, M., and Pereira-Wilson, C. Drinking of Salvia officinalis tea increases CCl(4)-induced hepatotoxicity in mice. Food Chem.Toxicol. 2007;45(3):456-464. View abstract.
- Lima, C. F., Valentao, P. C., Andrade, P. B., Seabra, R. M., Fernandes-Ferreira, M., and Pereira-Wilson, C. Water and methanolic extracts of Salvia officinalis protect HepG2 cells from t-BHP induced oxidative damage. Chem Biol Interact. 4-25-2007;167(2):107-115. View abstract.
- Loizzo, M. R., Tundis, R., Menichini, F., Saab, A. M., Statti, G. A., and Menichini, F. Cytotoxic activity of essential oils from labiatae and lauraceae families against in vitro human tumor models. Anticancer Res 2007;27(5A):3293-3299. View abstract.
- Lovenich, H., Schutt-Gerowitt, H., Keulertz, C., Waldschmidt, D., Bethe, U., Sohngen, D., and Cornely, O. A. Failure of anti-infective mouth rinses and concomitant antibiotic prophylaxis to decrease oral mucosal colonization in autologous stem cell transplantation. Bone Marrow Transplant. 2005;35(10):997-1001. View abstract.
- Masuda, T., Inaba, Y., and Takeda, Y. Antioxidant mechanism of carnosic acid: structural identification of two oxidation products. J Agric.Food Chem. 2001;49(11):5560-5565. View abstract.
- Masuda, T., Inaba, Y., Maekawa, T., Takeda, Y., Tamura, H., and Yamaguchi, H. Recovery mechanism of the antioxidant activity from carnosic acid quinone, an oxidized sage and rosemary antioxidant. J Agric.Food Chem. 10-9-2002;50(21):5863-5869. View abstract.
- Mayer, B., Baggio, C. H., Freitas, C. S., dos Santos, A. C., Twardowschy, A., Horst, H., Pizzolatti, M. G., Micke, G. A., Heller, M., dos Santos, E. P., Otuki, M. F., and Marques, M. C. Gastroprotective constituents of Salvia officinalis L. Fitoterapia 2009;80(7):421-426. View abstract.
- Mayer, E., Gescheidt-Shoshany, H., and Weltfriend, S. Allergic contact dermatitis caused by Salvia officinalis extract. Contact Dermatitis 2011;64(4):237-238. View abstract.
- Millet, Y., Tognetti, P., Lavaire-Pierovisi, M., Steinmetz, M-D., Arditti, J., and Jouglard, J. Etude experimentale des proprietes toxiques convulsivantes des essences de sauge et d'hysope du commerce. Rev EEG Neurophysiol 1979;(9):-12.
- Molochko, V. A., Lastochkina, T. M., Krylov, I. A., and Brangulis, K. A. [The antistaphylococcal properties of plant extracts in relation to their prospective use as therapeutic and prophylactic formulations for the skin]. Vestn.Dermatol Venerol. 1990;(8):54-56. View abstract.
- Moss, L., Rouse, M., Wesnes, K. A., and Moss, M. Differential effects of the aromas of Salvia species on memory and mood. Hum.Psychopharmacol. 2010;25(5):388-396. View abstract.
- Muhlbauer, R. C., Lozano, A., Palacio, S., Reinli, A., and Felix, R. Common herbs, essential oils, and monoterpenes potently modulate bone metabolism. Bone 2003;32(4):372-380. View abstract.
- Munne-Bosch, S. and Alegre, L. Drought-induced changes in the redox state of alpha-tocopherol, ascorbate, and the diterpene carnosic acid in chloroplasts of Labiatae species differing in carnosic acid contents. Plant Physiol 2003;131(4):1816-1825. View abstract.
- Nolkemper, S., Reichling, J., Stintzing, F. C., Carle, R., and Schnitzler, P. Antiviral effect of aqueous extracts from species of the Lamiaceae family against Herpes simplex virus type 1 and type 2 in vitro. Planta Med 2006;72(15):1378-1382. View abstract.
- Adams, M., Gmunder, F., and Hamburger, M. Plants traditionally used in age related brain disorders--a survey of ethnobotanical literature. J Ethnopharmacol 9-25-2007;113(3):363-381. View abstract.
- Aherne, S. A., Kerry, J. P., and O'Brien, N. M. Effects of plant extracts on antioxidant status and oxidant-induced stress in Caco-2 cells. Br.J Nutr 2007;97(2):321-328. View abstract.
- Akhondzadeh, S. and Abbasi, S. H. Herbal medicine in the treatment of Alzheimer's disease. Am J Alzheimers.Dis Other Demen. 2006;21(2):113-118. View abstract.
- Amin, A. and Hamza, A. A. Hepatoprotective effects of Hibiscus, Rosmarinus and Salvia on azathioprine-induced toxicity in rats. Life Sci 6-3-2005;77(3):266-278. View abstract.
- Baricevic, D., Sosa, S., Della, Loggia R., Tubaro, A., Simonovska, B., Krasna, A., and Zupancic, A. Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of ursolic acid. J Ethnopharmacol. 2001;75(2-3):125-132. View abstract.
- Bisset, N. G. Max Wichtl Herbal Drugs and Phytopharmaceuticals: A Handbook for Practice on a Scientific Basis. Boca Raton: CRC Press;1994.
- Bodiroga, T., Bodiroga, M., and Ognjanovic, J. Etheric oils in aromatherapia in Yugoslavia. Int Pharm Fed World Cong 2002;62:135.
- Bol'shakova, I. V., Lozovskaia, E. L., and Sapezhinskii, I. I. [Antioxidant properties of plant extracts]. Biofizika 1998;43(2):186-188. View abstract.
- Bozin, B., Mimica-Dukic, N., Samojlik, I., and Jovin, E. Antimicrobial and antioxidant properties of rosemary and sage (Rosmarinus officinalis L. and Salvia officinalis L., Lamiaceae) essential oils. J Agric.Food Chem. 9-19-2007;55(19):7879-7885. View abstract.
- Cwikla, C., Schmidt, K., Matthias, A., Bone, K. M., Lehmann, R., and Tiralongo, E. Investigations into the antibacterial activities of phytotherapeutics against Helicobacter pylori and Campylobacter jejuni. Phytother.Res 2010;24(5):649-656. View abstract.
- da Rocha, M. D., Viegas, F. P., Campos, H. C., Nicastro, P. C., Fossaluzza, P. C., Fraga, C. A., Barreiro, E. J., and Viegas, C., Jr. The role of natural products in the discovery of new drug candidates for the treatment of neurodegenerative disorders II: Alzheimer's disease. CNS.Neurol.Disord.Drug Targets. 2011;10(2):251-270. View abstract.
- De, Leo, V, Lanzetta, D., Cazzavacca, R., and Morgante, G. [Treatment of neurovegetative menopausal symptoms with a phytotherapeutic agent]. Minerva Ginecol. 1998;50(5):207-211. View abstract.
- Dos Santos-Neto, L. L., Vilhena Toledo, M. A., Medeiros-Souza, P., and de Souza, G. A. The use of herbal medicine in Alzheimer's disease-a systematic review. Evid.Based.Complement Alternat.Med 2006;3(4):441-445. View abstract.
- Eidi, M., Eidi, A., and Bahar, M. Effects of Salvia officinalis L. (sage) leaves on memory retention and its interaction with the cholinergic system in rats. Nutrition 2006;22(3):321-326. View abstract.
- Eidi, M., Eidi, A., and Zamanizadeh, H. Effect of Salvia officinalis L. leaves on serum glucose and insulin in healthy and streptozotocin-induced diabetic rats. J Ethnopharmacol. 9-14-2005;100(3):310-313. View abstract.
- Feres, M., Figueiredo, L. C., Barreto, I. M., Coelho, M. H., Araujo, M. W., and Cortelli, S. C. In vitro antimicrobial activity of plant extracts and propolis in saliva samples of healthy and periodontally-involved subjects. J Int.Acad.Periodontol. 2005;7(3):90-96. View abstract.
- Fortes, C., Forastiere, F., Farchi, S., Mallone, S., Trequattrinni, T., Anatra, F., Schmid, G., and Perucci, C. A. The protective effect of the Mediterranean diet on lung cancer. Nutr Cancer 2003;46(1):30-37. View abstract.
- Futrell, J. M. and Rietschel, R. L. Spice allergy evaluated by results of patch tests. Cutis 1993;52(5):288-290. View abstract.
- Geuenich, S., Goffinet, C., Venzke, S., Nolkemper, S., Baumann, I., Plinkert, P., Reichling, J., and Keppler, O. T. Aqueous extracts from peppermint, sage and lemon balm leaves display potent anti-HIV-1 activity by increasing the virion density. Retrovirology. 2008;5:27. View abstract.
- Guaschino, S. and Benvenuti, C. SOPHY project: an observational study of vaginal pH, lifestyle and correct intimate hygiene in women of different ages and in different physiopathological conditions. Part II. Minerva Ginecol. 2008;60(5):353-362. View abstract.
- Halicioglu, O., Astarcioglu, G., Yaprak, I., and Aydinlioglu, H. Toxicity of Salvia officinalis in a newborn and a child: an alarming report. Pediatr.Neurol. 2011;45(4):259-260. View abstract.
- Hayouni, el A., Chraief, I., Abedrabba, M., Bouix, M., Leveau, J. Y., Mohammed, H., and Hamdi, M. Tunisian Salvia officinalis L. and Schinus molle L. essential oils: their chemical compositions and their preservative effects against Salmonella inoculated in minced beef meat. Int J Food Microbiol. 7-31-2008;125(3):242-251. View abstract.
- Hellum, B. H. and Nilsen, O. G. In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products. Basic Clin Pharmacol Toxicol. 2008;102(5):466-475. View abstract.
- Hold, K. M., Sirisoma, N. S., Ikeda, T., Narahashi, T., and Casida, J. E. Alpha-thujone (the active component of absinthe): gamma-aminobutyric acid type A receptor modulation and metabolic detoxification. Proc Natl Acad Sci USA 2000;(97):3826-3831.
- Horiuchi, K., Shiota, S., Hatano, T., Yoshida, T., Kuroda, T., and Tsuchiya, T. Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE). Biol.Pharm.Bull. 2007;30(6):1147-1149. View abstract.
- Horiuchi, K., Shiota, S., Kuroda, T., Hatano, T., Yoshida, T., and Tsuchiya, T. Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis. Biol.Pharm.Bull. 2007;30(2):287-290. View abstract.
- Howes, M. J. and Perry, E. The role of phytochemicals in the treatment and prevention of dementia. Drugs Aging 6-1-2011;28(6):439-468. View abstract.
- Hubbert, M., Sievers, H., Lehnfeld, R., and Kehrl, W. Efficacy and tolerability of a spray with Salvia officinalis in the treatment of acute pharyngitis - a randomised, double-blind, placebo-controlled study with adaptive design and interim analysis. Eur J Med Res 1-31-2006;11(1):20-26. View abstract.
- Iuvone, T., De Filippis, D., Esposito, G., D'Amico, A., and Izzo, A. A. The spice sage and its active ingredient rosmarinic acid protect PC12 cells from amyloid-beta peptide-induced neurotoxicity. J Pharmacol Exp Ther 2006;317(3):1143-1149. View abstract.
- Jedinak, A., Muckova, M., Kost'alova, D., Maliar, T., and Masterova, I. Antiprotease and antimetastatic activity of ursolic acid isolated from Salvia officinalis. Z Naturforsch.C. 2006;61(11-12):777-782. View abstract.
- Johnson, J. J. Carnosol: a promising anti-cancer and anti-inflammatory agent. Cancer Lett. 6-1-2011;305(1):1-7. View abstract.
- Juhas, S., Cikos, S., Czikkova, S., Vesela, J., Il'kova, G., Hajek, T., Domaracka, K., Domaracky, M., Bujnakova, D., Rehak, P., and Koppel, J. Effects of borneol and thymoquinone on TNBS-induced colitis in mice. Folia Biol.(Praha) 2008;54(1):1-7. View abstract.
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