Apricot Vine, Corona de Cristo, Fleischfarbige, Fleur de la Passion, Fleur de Passiflore, Flor de Passion, Grenadille, Madre Selva, Maracuja, Maypop, Maypop Passion Flower, Pasiflora, Passiflora, Passiflora incarnata, Passiflorae Herba, Passiflore, Passiflore Aubépine, Passiflore Officinale, Passiflore Purpurine, Passiflore Rouge, Passiflorina, Passion Vine, Passionaria, Passionblume, Passionflower Herb, Passionsblumenkraut, Purple Passion Flower, Water Lemon, Wild Passion Flower.<br/><br/>
Overview InformationPassionflower is a plant. The above ground parts are used to make medicine.
Passionflower is used for sleep problems (insomnia), gastrointestinal (GI) upset related to anxiety or nervousness, generalized anxiety disorder (GAD), and relieving symptoms related to narcotic drug withdrawal.
Passionflower is also used for seizures, hysteria, asthma, symptoms of menopause, attention deficit-hyperactivity disorder (ADHD), nervousness and excitability, palpitations, irregular heartbeat, high blood pressure, fibromyalgia, and pain relief.
Some people apply passionflower to the skin for hemorrhoids, burns, and pain and swelling (inflammation).
In foods and beverages, passionflower extract is used as a flavoring.
In 1569, Spanish explorers discovered passionflower in Peru. They believed the flowers symbolized Christ’s passion and indicated his approval for their exploration. Passionflower is found in combination herbal products used as a sedative for promoting calmness and relaxation. Other herbs contained in these products include German chamomile, hops, kava, skullcap, and valerian.
Passionflower was formerly approved as an over-the-counter sedative and sleep aid in the U.S., but it was taken off the market in 1978 because safety and effectiveness had not been proven. However, passionflower may still be available alone or in combination with other herbal products.
How does it work?The chemicals in passionflower have calming, sleep inducing, and muscle spasm relieving effects.
Uses & Effectiveness
Possibly Effective for
- Anxiety. There is some evidence that passionflower can reduce symptoms of anxiety, sometimes as effectively as some prescription medications.
- Relieving symptoms related to narcotic drug withdrawal, when used in combination with a medication called clonidine. This combination seems to be effective in reducing symptoms such as anxiety, irritability, sleep problems (insomnia), and agitation. However, passionflower plus clonidine is no better than clonidine alone for physical symptoms such as tremor and nausea.
- Relieving symptoms of a psychiatric disorder known as “adjustment disorder with anxious mood” when used in a multi-ingredient product (Euphytose, EUP). Other herbs in the product are crataegus, ballota, and valerian, which have mild sedative effects, and cola and paullinia, which have stimulant effects. It’s not clear, though, which ingredient or ingredients in the mix are responsible for decreasing anxiety.
Insufficient Evidence for
- Trouble sleeping (insomnia). Some preliminary research suggests that drinking a passionflower tea an hour before bedtime might help improve feelings of sleep quality. However, this did not seem to improve the time it takes to fall asleep, the number of awakenings at night, or refreshed feelings upon awakening in the morning.
- Nervous stomach.
- Heart problems.
- High blood pressure.
- Other conditions.
Side Effects & SafetyPassionflower is LIKELY SAFE for most people when taken by mouth in amounts normally found in food. It is POSSIBLY SAFE when taken short-term (less than two months) as medicine or tea. It is POSSIBLY UNSAFE when taken by mouth in large amounts.
Passionflower can cause some side effects such as dizziness, confusion, irregular muscle action and coordination, altered consciousness, and inflamed blood vessels. There has also been a report of nausea, vomiting, drowsiness, a rapid heart rate, and abnormal heart rhythm in one person who took it.
There isn’t enough information to rate the safety of passionflower when applied to the skin.
Special Precautions & Warnings:Pregnancy and breast-feeding: Don’t take passionflower if you are pregnant. It is UNSAFE. There are some chemicals in passionflower that might cause the uterus to contract.
Not enough is known about the safety of taking passionflower during breast-feeding. Stay on the safe side and don’t use it.
Surgery: Passionflower can affect the central nervous system. It might increase the effects of anesthesia and other medications on the brain during and after surgery. Stop taking passionflower at least 2 weeks before a scheduled surgery.
Be cautious with this combination
Sedative medications (CNS depressants) interacts with PASSIONFLOWER
Passionflower might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking passionflower along with sedative medications might cause too much sleepiness.<br /><br /> Some sedative medications include pentobarbital (Nembutal), phenobarbital (Luminal), secobarbital (Seconal), clonazepam (Klonopin), lorazepam (Ativan), zolpidem (Ambien), and others.
The following doses have been studied in scientific research:
- For generalized anxiety disorder (GAD):
- 45 drops of passionflower liquid extract daily.
- A specific tablet formulation 90 mg/day has also been used.
- For reducing symptoms associated with narcotic drug withdrawal: 60 drops of passionflower liquid extract in combination with 0.8 mg of clonidine.
- Brown, E., Hurd, N. S., McCall, S., and Ceremuga, T. E. Evaluation of the anxiolytic effects of chrysin, a Passiflora incarnata extract, in the laboratory rat. AANA.J 2007;75(5):333-337. View abstract.
- Dhawan, K., Kumar, S., and Sharma, A. Comparative biological activity study on Passiflora incarnata and P. edulis. Fitoterapia 2001;72(6):698-702. View abstract.
- Gerhard, U., Hobi, V., Kocher, R., and Konig, C. [Acute sedatiing effect of a herbal tranquilizer compared to that of bromazepam]. Schweiz.Rundsch.Med.Prax. 12-27-1991;80(52):1481-1486. View abstract.
- Nassiri-Asl, M., Shariati-Rad, S., and Zamansoltani, F. Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors. BMC.Complement Altern Med 2007;7:26. View abstract.
- Rickels, K. and Hesbacher, P. T. Over-the-counter daytime sedatives. A controlled study. JAMA 1-1-1973;223(1):29-33. View abstract.
- Smith, G. W., Chalmers, T. M., and Nuki, G. Vasculitis associated with herbal preparation containing Passiflora extract. Br J Rheumatol. 1993;32(1):87-88. View abstract.
- Soulimani, R., Younos, C., Jarmouni, S., Bousta, D., Misslin, R., and Mortier, F. Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. J Ethnopharmacol. 1997;57(1):11-20. View abstract.
- Von Eiff M, Brunner H, Haegeli A, and et al. Hawthorn / passion flower extract and improvement in physical exercise capacity of patients with dyspnoea Class II of the NYHA functional classifications. Acta Therapeutica 1994;20:47-66.
- Wolfman, C., Viola, H., Paladini, A., Dajas, F., and Medina, J. H. Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea. Pharmacol Biochem Behav 1994;47(1):1-4. View abstract.
- Yaniv, R., Segal, E., Trau, H., Auslander, S., and Perel, A. Natural premedication for mast cell proliferative disorders. J Ethnopharmacol. 1995;46(1):71-72. View abstract.
- Akhondzadeh S, Kashani L, Mobaseri M, et al. Passionflower in the treatment of opiates withdrawal: a double-blind randomized controlled trial. J Clin Pharm Ther 2001;26:369-73. View abstract.
- Akhondzadeh S, Mohammadi MR, Momeni F. Passiflora incarnata in the treatment of attention-deficit hyperactivity disorder in children and adolescents. Therapy 2005;2(4):609-14.
- Akhondzadeh S, Naghavi HR, Shayeganpour A, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001;26:363-7. View abstract.
- Ansseau M, Seidel L, Crosset A, Dierckxsens Y, Albert A. A dry extract of Passiflora incarnata L. (Sedanxio) as first intention treatment of patients consulting for anxiety problems in general practice. Acta Psychiatrica Belgica 2012;112(3):5-11.
- Aoyagi N, Kimura R, Murata T. Studies on passiflora incarnata dry extract. I. Isolation of maltol and pharmacological action of maltol and ethyl maltol. Chem Pharm Bull 1974;22:1008-13. View abstract.
- Appel K, Rose T, Fiebich B, et al. Modulation of the gamma-aminobutyric acid (GABA) system by Passiflora incarnata L. Phytother Res 2011;25:838-43. View abstract.
- Aslanargun P, Cuvas O, Dikmen B, Aslan E, Yuksel MU. Passiflora incarnata Linneaus as an anxiolytic before spinal anesthesia. J Anesth 2012;26(1):39-44. View abstract.
- Bourin M, Bougerol T, Guitton B, Broutin E. A combination of plant extracts in the treatment of outpatients with adjustment disorder with anxious mood: controlled study vs placebo. Fundam Clin Pharmacol 1997;11:127-32. View abstract.
- Capasso A., Sorrentino L. Pharmacological studies on the sedative and hypnotic effect of Kava kava and Passiflora extracts combination. Phytomedicine. 2005;12:39-45. View abstract.
- Carrasco MC, Vallejo JR, Pardo-de-Santayana M, et al. Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytother Res. 2009 Dec;23:1795-6. View abstract.
- Code of Federal Regulations Title 21, Chapter 1, Subchapter B, section 172.510: Natural flavoring substances and natural substances used in conjunction with flavors. www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/cfrsearch.cfm?fr=172.510 (accessed 02/22/16).
- Dhawan K, Kumar S, Sharma A. Anti-anxiety studies on extracts of Passiflora incarnata Linneaus. J Ethnopharmacol 2001;78:165-70.. View abstract.
- Dhawan K, Kumar S, Sharma A. Anxiolytic activity of aerial and underground parts of Passiflora incarnata. Fitoterapia 2001;72:922-6.. View abstract.
- Farnsworth N, Bingel A, Cordell G, et al. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98. View abstract.
- Fisher AA, Purcell P, Le Couteur DG. Toxicity of Passiflora incarnata L. J Toxicol Clin Toxicol 2000;38:63-6. View abstract.
- Foster S, Tyler VE. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999.
- Gralla EJ, Stebbins RB, Coleman GL, Delahunt CS. Toxicity studies with ethyl maltol. Toxicol Appl Pharmacol 1969;15:604-13. View abstract.
- Grundmann O, Wang J, McGregor GP, Butterweck V. Anxiolytic activity of a phytochemically characterized Passiflora incarnata extract is mediated via the GABAergic system. Planta Medica 2008;74:1769-73. View abstract.
- Kaviani N, Tavakoli M, Tabanmehr M, Havaei R. The efficacy of Passiflora incarnata Linnaeus in reducing dental anxiety in patients undergoing periodontal treatment. J Dent (Shiraz) 2013;14(2):68-72. View abstract.
- Maroo N, Hazra A, Das T. Efficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trial. Indian J Pharmacol 2013;45(1):34-9. View abstract.
- Medina JH, Paladini AC, Wolfman C, et al. Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties. Biochem Pharmacol 1990;40:2227-31. View abstract.
- Miroddi M, Calapai G, Navarra M, et al. Passiflora incarnata L: ethnopharmacology, clinical application, safety and evaluation of clinical trials. J Ethnopharmacol 2013;150:791-804. View abstract.
- Miyasaka LS, Atallah AN, Soares BG. Passiflora for anxiety disorder. Cochrane Database Syst Rev 2007;(1):CD004518. View abstract.
- Mori A, Hasegawa K, Murasaki M, et al. Clinical evaluation of Passiflamin (passiflora extract) on neurosis - multicenter double blind study in comparison with mexazolam. Rinsho Hyoka (Clinical Evaluation) 1993;21:383-440.
- Movafegh A, Alizadeh R, Hajimohamadi F, Esfehani F, Nejatfar M. Preoperative oral Passiflora incarnata reduces anxiety in ambulatory surgery patients: a double-blind, placebo-controlled study. Anesth Analg 2008;106:1728-32. View abstract.
- Ngan A, Conduit R. A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (Passionflower) herbal tea on subjective sleep quality. Phytother Res 2011;25:1153-9. View abstract.
- Patel SS, Mohamed Saleem TS, Ravi V, et al. Passiflora incarnata Linn: a phytopharmacological review. Int J Green Pharmacy 2009;Oct-Dec:277-80.
- Rommelspacher H, May T, Salewski B. (1-methyl-beta-carboline) is a natural inhibitor of monoamine oxidase type A in rats. Eur J Pharmacol 1994;252:51-9.. View abstract.
- Salgueiro JB, Ardenghi P, Dias M, et al. Anxiolytic natural and synthetic flavonoid ligands of the central benzodiazepine receptor have no effect on memory tasks in rats. Pharmacol Biochem Behav 1997;58:887-91. View abstract.
- Speroni E., Minghetti A. Neuropharmacological activity of extracts from Passiflora incarnata. Planta Med. 1988;54:488-91. View abstract.
- Von Eiff M, Brunner H, Haegeli A, et al. Hawthorn / passion flower extract and improvement in physical exercise capacity of patients with dyspnoea Class II of the NYHA functional classifications. Acta Therapeutica 1994;20:47-66.