Melanotan II, MT-II.<br/><br/>


Overview Information

Melanotan-II is a lab-made chemical that is similar to a hormone found in people. Be careful not to confuse melanotan-II with melatonin.

Melanotan-II is given as a shot to produce erections in men with ED (erectile dysfunction), tan the skin, and prevent skin cancers caused by sun exposure.

How does it work?

Melanotan-II is similar to a substance in our bodies, called “melanocyte-stimulating hormone,” which increases the production of skin-darkening pigments. Melanotan-II might also work in the brain to stimulate erections of the penis.


Uses & Effectiveness?

Possibly Effective for

  • Producing erections in men with ED (erectile dysfunction), when given as a shot under the skin.
  • Tanning of the skin, when given as a shot under the skin.

Insufficient Evidence for

  • Preventing skin cancers due to sun exposure, when given as a shot under the skin.
  • Other conditions.
More evidence is needed to rate the effectiveness of melanotan-II for these uses.

Side Effects

Side Effects & Safety

Melanotan-II is POSSIBLY SAFE when used under medical supervision for treating ED (erectile dysfunction). It may cause nausea, stomachcramps, decreased appetite, flushing, tiredness, yawning, darkened skin, spontaneous erections of the penis, and other side effects.

There isn't enough information to know whether melanotan-II is safe for other uses.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of melanotan-II during pregnancy and breast-feeding. Stay on the safe side and avoid use.



We currently have no information for MELANOTAN-II Interactions.



The following doses have been studied in scientific research:


  • For causing an erection in men with ED: the typical dosage of melanotan-II is 0.025 mg/kg.
  • For tanning skin: the typical dosage of melanotan-II is 0.025 mg/kg.

View References


  • Dorr RT, Lines R, Levine N, et al. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life Sci 1996;58:1777-84. View abstract.
  • Hadley ME, Hruby VJ, Blanchard J, et al. Discoverdevelopment of novel melanogenic drugs. Melanotan-I and -II. Pharm Biotechnol 1998;11:575-95.
  • Lan EL, Ugwu SO, Blanchard J, et al. Preformulation studies with melanotan II: a potential skin cancer chemopreventive peptide. J Pharm Sci 1994;83:1081-4. View abstract.
  • Pinsuwan S, Myrdal PB, Yalkowsky SH. Systemic delivery of melanotan II through the ocular route in rabbits. J Pharm Sci 1997;86:396-7.
  • Wessells H, Fuciarelli K, Hansen J, et al. Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction; double-blind, placebo controlled crossover study. J Urol 1998;160:389-93. View abstract.
  • Wessells H, Gralnek DR, Dorr RT, et al. Erectogenic properties of melanotan II in men with organic erectile dysfunction. 1999. Abstract Info-American Urological Association, Inc.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.