Strattera and all the other nonstimulants are generally considered to be less effective than psychostimulants in the treatment of ADHD. The nonstimulants are considered second- and third-line medications.

Strattera works on the neurotransmitter (chemical in the brain that transmits nerve impulses) called norepinephrine. Like the stimulant drugs, Strattera is effective in treating and controlling ADHD symptoms, but it is not a controlled substance and people are less likely to abuse the drug or become dependent on it.

In addition, Strattera doesn't cause many of the potential side effects linked to psychostimulants, such as sleeplessness. However, Strattera can cause other side effects including abdominal pain, nausea, and drowsiness, especially when starting the medication. What Strattera does better than the stimulant medications is provide a longer and smoother action without the "roller coaster" effect of the stimulant starting to work and then wearing off.

How Does Strattera Work?

This medication works by increasing the amount of norepinephrine, an important brain chemical, in the brain. Doing this appears to help ADHD by increasing attention span and reducing impulsive behavior and hyperactivity.

What Are the Side Effects of Strattera?

The most common side effects seen with Strattera are:

Upset stomach
Decreased appetite, which may cause weight loss
Nausea
Dizziness
Fatigue
Mood swings

These side effects can be significant and may require stopping the medication.

Generally, these side effects are not severe, and only a very small percentage of clinical trial participants stopped Strattera due to side effects.

There have been reports of slightly decreased growth in children and teens. It is recommended that children and adolescents be observed, measured, and weighed periodically while on Strattera.

Allergic reactions to Strattera are rare but do occur, usually as swelling or hives. The prescribing doctor or other health care professional should be advised immediately if anyone taking Strattera develops a skin rash, swelling, hives, or other allergic symptoms.

On Dec. 17, 2004, Eli Lilly, the makers of Strattera, added a warning to the drug noting that Strattera should be stopped in patients with signs of jaundice -- yellowing of the skin or whites of the eyes. Jaundice is a sign of liver damage. If blood tests show evidence of liver damage, the drug should also be stopped.

In September 2005, the manufacturer added a warning stating that the drug can increase suicidal thinking in teens who take the drug.

Who Shouldn't Take Strattera?

There are certain situations in which a person should not take Strattera. If you or your child has any of the following conditions, you should discuss them with your health care provider before taking Strattera:

Narrow angle glaucoma (a condition that causes increased pressure in the eyes and can lead to blindness).
Treatment with a type of antidepressant called monoamine oxidase inhibitors, such as Nardil or Parnate, within 14 days of starting Strattera.