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When your lower back is achy and sore, everything you do -- from reaching into a kitchen cabinet to bending over to pet the dog -- can trigger an excruciating jolt of pain. At that time, it may feel as if nothing is more important than finding relief. Medications, like the ones listed in this guide, may help. But they should be used along with exercise and physical therapy for effective pain relief.

If you are considering medications to relieve your pain -- especially chronic back pain -- it’s also important to consider their risks and side effects. Certain drugs for low back pain may also interact with other medications you are taking. So, carefully weigh your options with your doctor when choosing medication.

Over-the-Counter Pain Relievers

People with lower back pain often try over-the-counter pain relievers first.

Nonsteroidal anti-inflammatory drugs (NSAIDs) -- including aspirin, naproxen sodium (Aleve, Naprosyn), and ibuprofen (Advil, Motrin) -- are among the most commonly used pain relievers. They work about equally well to improve mild inflammation, swelling, and lower back pain. Although NSAIDs are reasonably safe medications, it is important that you are aware of potential side effects. NSAIDs are safest when low doses are taken for brief periods. Side effects most commonly occur if you are taking large doses over a prolonged time (months or years) and can include stomach pain, bleeding, and stomach ulcers. 

Naproxen and ibuprofen and certain other prescription NSAIDs may increase the risk of heart attack or stroke in people who take them for a long time or in people with heart disease. You should see your doctor before taking NSAIDs for longer than 10 days.


Acetaminophen (Actamin, Panadol, Tylenol) is not an NSAID, but it can help with pain and doesn't raise the risk of stomach problems like NSAIDs do. However, taking more than the recommended amount of acetaminophen can cause liver damage, especially if you have underlying liver disease. So it's important not to take more than the dose recommended on the package.  If you have liver disease, check with your doctor before taking acetaminophen.

Opioid Pain Medications

Narcotic (or opioid) pain medicines such as codeine, oxycodone, hydrocodone, and morphine work by blocking the transmission of pain messages to the brain.  Narcotic drugs should only be used under a doctor’s supervision because they can cause physical dependence and addiction. Other side effects include severe drowsiness and constipation.

Muscle Relaxants

Muscle relaxants such as diazepam (Valium) or cyclobenzaprine (Amrix, Fexmid, Flexeril) act on the central nervous system to relieve painful muscle strains and spasms. However, these drugs can be habit-forming. Muscle relaxants also can cause side effects, including sedation and dizziness.



Some drugs typically prescribed to treat depression have also been shown to help relieve chronic lower back pain, and doctors sometimes prescribe these medications to alleviate pain. Duloxetine (Cymbalta) is approved for chronic musculoskeletal pain including pain from osteoarthritis and chronic low back pain. Low doses of tricyclic antidepressants such as amitriptyline (Elavil, Endep, Vanatrip) and desipramine (Norpramin) are often used to treat low back pain. Side effects of these drugs may include drowsiness, dizziness, dry mouth, and appetite loss.

Chronic Back Pain Exercises

Exercises you should and shouldn't do when you have back pain.
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