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    Optimism May Be Partly in Your Genes

    Researchers Zero in on Optimism, Self-Esteem Gene
    WebMD Health News
    Reviewed by Laura J. Martin, MD

    Sept. 16, 2011 -- Ever wonder why some people immediately see the bright side of just about any situation and seem to make friends wherever they go?

    Turns out, it may be in their genes. The findings appear online in the Proceedings of the National Academy of Sciences.

    Researchers have zeroed in on a possible genetic basis for optimism, self-esteem, and mastery (the belief that you have control over your own life and destiny). It’s rooted in the hormone oxytocin, also known as the love or cuddle hormone. Oxytocin is known to be plentiful in breastfeeding women and is released by men and women during orgasm.

    A little chunk of genetic material on the oxytocin receptor gene may influence these personality traits. Exactly how the gene affects the release of oxytocin is not fully understood. A combination of two variants -- an “A” and “G” -- are located in this small area.

    In the study, 326 study participants answered questions about their optimism, self-esteem, and mastery. Researchers analyzed genetic material in their saliva to see how the variants of the gene correlated with the self-assessments. Participants also completed a standardized tool that measures depression.

    A Look at the Gene

    The gene can backfire on you too.

    People with a gene variation including one or two A’s were found to have less optimism, mastery, and self-esteem, and more symptoms of depression than people with a variation including two G's.

    If you have two G’s however, you are more likely to see the world -- and your role in it -- in a positive light.

    “If you have an A, the deck is stacked against you somewhat,” says Shelley E Taylor, PhD. She is a distinguished professor of psychology at the University of California at Los Angeles. Taylor credits her graduate student Shimon Saphire-Bernstein with pinpointing the region on the gene that hosts these traits.

    The combination affects how you see the world and your role in it. But you are not destined to be happy or sad based on your genetic make-up. Not at all, she says.

    Genes predict behavior, but they are not the be-all, end-all. “There is a lot of room for environmental variations, like how you were raised and the life experiences that you have had,” she says.

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