Skip to content

    Bipolar Disorder Health Center

    Font Size
    A
    A
    A

    Anticonvulsant Medication for Bipolar Disorder

    Several anticonvulsant medications are recognized as mood stabilizers to treat or prevent mood episodes in bipolar disorder. At first, anticonvulsants were prescribed only for people who did not respond to lithium. Today, they are often prescribed alone, with lithium, or with an antipsychotic drug to control mania.

    Anticonvulsants work by calming hyperactivity in the brain in various ways. For this reason, some of these drugs are used to treat epilepsy, prevent migraines, and treat other brain disorders. They are often prescribed for people who have rapid cycling -- four or more episodes of mania and depression in a year.

    Recommended Related to Bipolar Disorder

    Bipolar Disorder: Who’s at Risk?

    Bipolar disorder, also known as manic depression, is an illness in which a person has periods of high mood and energy and other times of depression. People diagnosed with bipolar disorder usually have one or more major depressive episodes along with one or more manic or mixed episodes. Bipolar mania is a prolonged state (at least one week at a time) of extreme elation or agitation accompanied by excessive energy. Symptoms of the manic "highs" include increased energy, racing thoughts and fast...

    Read the Bipolar Disorder: Who’s at Risk? article > >

    Anticonvulsants used to treat bipolar disorder include:

    These medicines differ in the types of bipolar symptoms they treat. Depakote and Tegretol, for example, tend to be more effective in treating mania than depressive symptoms while Lamictal appears to have stronger antidepressant than antimanic effects. Lamictal also is used more often to prevent future episodes (rather than treat current episodes). Depakote and Tegretol are used to treat acute episodes more than as preventative treatments. Other anticonvulsants are less well-established for treating mood symptoms in bipolar disorder, and some -- such as Neurontin, Lyrica, or Topamax -- are also used "off label" for other types of problems such as anxiety or weight loss.

    Each anticonvulsant acts on the brain in slightly different ways, so your experience may differ depending on the drug you take. In general, however, these drugs are at maximal effectiveness after taking them for several weeks.

    Anticonvulsant Side Effects

    Your doctor may want to take occasional blood tests to monitor your health while taking an anticonvulsant. Some anticonvulsants can cause liver or kidney damage or decrease the amount of platelets in your blood. Your blood needs platelets to clot.

    Each anticonvulsant may have slightly different side effects. Common side effects include:

    Most of these side effects lessen with time. Long-term effects vary from drug to drug. In general:

    • Pregnant women should not take anticonvulsants without consulting with their doctor, because they may increase the risk of birth defects.
    • Some anticonvulsants can cause problems with the liver over the long term, so your doctor may monitor your liver periodically.

    Anticonvulsants can interact with other drugs -- even aspirin -- to cause serious problems. Be sure to tell your doctor about any drugs, herbs, or supplements you take. Don't take any other substance during treatment without talking with your doctor.

    WebMD Medical Reference

    Reviewed by Joseph Goldberg, MD on September 11, 2014

    Today on WebMD

    lunar eclipse
    Signs of mania and depression.
    Pills on blank prescription paper
    Learn about this popular bipolar disorder medication.
     
    serious looking young woman
    Assess your symptoms.
    teen girl in bad mood
    How is each one different?
     
    Feeling Ups and Downs
    ASSESSMENT
    Bipolar or Schizo
    Article
     
    Foods to Avoid
    Article
    Man being scolded by his shadow
    Article
     
    lunar eclipse
    Slideshow
    depressed man
    Article
     
    young women not speaking
    Article
    man talking with therapist
    Article