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Stage Information for Colon Cancer

    Table 3. Definitions of TNM Stage II

    StageTNMa,bDukescMACdDescriptionIllustration
    T = primary tumor; N = regional lymph nodes; M = distant metastasis.
    Reprinted with permission from AJCC: Colon and rectum. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 143-164.
    The explanations for superscripts a–g are at the end ofTable 5.
    IIA
    T3, N0, M0
    B
    B2
    T3 = Tumor invades through the muscularis propria into pericolorectal tissues.

    cdr0000688428.jpg
    N0 = No regional lymph node metastasis.
    M0 = No distant metastasis.
    IIBT4a, N0, M0BB2T4a = Tumor penetrates to the surface of the visceral peritoneum.f
    N0 = No regional lymph node metastasis.
    M0 = No distant metastasis.
    IICT4b, N0, M0BB3T4b = Tumor directly invades or is adherent to other organs or structures.f,g
    N0 = No regional lymph node metastasis.
    M0 = No distant metastasis.

    Table 4. Definitions of TNM Stage III

    StageTNMa,bDukescMACdDescriptionIllustration
    T = primary tumor; N = regional lymph nodes; M = distant metastasis.
    Reprinted with permission from AJCC: Colon and rectum. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 143-164.
    The explanations for superscripts a–g are at the end ofTable 5.
    IIIA
    T1–T2, N1/N1c, M0
    C
    C1
    T1 = Tumor invades submucosa.

    cdr0000688429.jpg
    T2 = Tumor invades muscularis propria.
    N1 = Metastases in 1–3 regional lymph nodes.
    T1, N2a, M0CC1N1c = Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional nodal metastasis.
    N2a = Metastases in 4–6 regional lymph nodes.
    M0 = No distant metastasis.
    IIIB
    T3–T4a, N1/N1c, M0
    C
    C2
    T1 = Tumor invades submucosa.

    cdr0000688430.jpg
    T2 = Tumor invades muscularis propria.
    T3 = Tumor invades through the muscularis propria into pericolorectal tissues.
    T4a = Tumor penetrates to the surface of the visceral peritoneum.f
    N1 = Metastases in 1–3 regional lymph nodes.
    N1c = Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional nodal metastasis.
    T2–T3, N2a, M0CC1/C2N2a = Metastases in 4–6 regional lymph nodes.
    N2b = Metastases in ≥7 regional lymph nodes.
    T1–T2, N2b, M0CC1M0 = No distant metastasis.
    IIIC
    T4a, N2a, M0
    C
    C2
    T3 = Tumor invades through the muscularis propria into pericolorectal tissues.

    cdr0000688436.jpg
    T4a = Tumor penetrates to the surface of the visceral peritoneum.f
    T4b = Tumor directly invades or is adherent to other organs or structures.f,g
    T3–T4a, N2b, M0CC2N1 = Metastases in 1–3 regional lymph nodes.
    N2 = Metastases in ≥4 regional lymph nodes.
    N2a = Metastases in 4–6 regional lymph nodes.
    T4b, N1–N2, M0CC3N2b = Metastases in ≥7 regional lymph nodes.
    M0 = No distant metastasis.
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