Colorectal Cancer Health Center

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Drug combinations described in this section include the following:

• The Arbeitsgemeinschaft Internische Onkologie (AIO) or German AIO regimen (folic acid, 5-FU, and irinotecan):
  • Irinotecan (100 mg/m²) administered as a 2-hour infusion on day 1; leucovorin (500 mg/m²) administered as a 2-hour infusion on day 1; followed by 5-FU (2,000 mg/m²) intravenous (IV) bolus via ambulatory pump administered for a period of 24 hours on a weekly basis four times a year (52 weeks).
• The CAPOX regimen (capecitabine and oxaliplatin):
  • Capecitabine (1,000 mg/m²) twice a day on days 1 through 14 plus oxaliplatin (70 mg/m²) on days 1 and 8 every 3 weeks.
• The Douillard regimen (folic acid, 5-FU, and irinotecan):
  • Irinotecan (180 mg/m²) administered as a 2-hour infusion on day 1; leucovorin (200 mg/m²) administered as a 2-hour infusion on day 1 and day 2; followed by a loading dose of 5-FU (400 mg/m²) IV bolus, then 5-FU (600 mg/m²) via ambulatory pump administered for a period of 22 hours on day 1 and day 2 every 2 weeks.
• The FOLFOX4 regimen (oxaliplatin, leucovorin, and 5-FU):
  • Oxaliplatin (85 mg/m²) administered as a 2-hour infusion on day 1; leucovorin (200 mg/m²) administered as a 2-hour infusion on day 1 and day 2; followed by a loading dose of 5-FU (400 mg/m²) IV bolus, then 5-FU (600 mg/m²) administered via ambulatory pump for a period of 22 hours on day 1 and day 2 every 2 weeks.
• The FOLFOX6 regimen (oxaliplatin, leucovorin, and 5-FU):
  • Oxaliplatin (85-100 mg/m²) administered as a 2-hour infusion on day 1; leucovorin (400 mg/m²) administered as a 2-hour infusion on day 1; followed by a loading dose of 5-FU (400 mg/m²) IV bolus on day 1, then 5-FU (2,400-3,000 mg/m²) administered via ambulatory pump for a period of 46 hours every 2 weeks.
• The FOLFIRI regimen (folic acid, 5-FU, and irinotecan):
  • Irinotecan (180 mg/m²) administered as a 2-hour infusion on day 1; leucovorin (400 mg/m²) administered as a 2-hour infusion on day 1; followed by a loading dose of 5-FU (400 mg/m²) IV bolus administered on day 1, then 5-FU (2,400-3,000 mg/m²) administered via ambulatory pump for a period of 46 hours every 2 weeks.
• The FUFOX regimen (fluorouracil, leucovorin, and oxaliplatin):
  • Oxaliplatin (50 mg/m²) plus leucovorin (500 mg/m²) plus 5-FU (2,000 mg/m²) as a 22-hour continuous infusion on days 1, 8, 22, and 29 every 36 days.
• The FUOX regimen (fluorouracil plus oxaliplatin):
  • Continuous infusion 5-FU (2,250 mg/m²) during 48 hours on days 1, 8, 15, 22, 29 and 36 plus oxaliplatin (85 mg/m²) on days 1, 15, and 29 every 6 weeks.
• IFL (or Saltz) regimen (irinotecan, 5-FU, and leucovorin):
  • Irinotecan (125 mg/m²), 5-FU (500 mg/m²) IV bolus, and leucovorin (20 mg/m²) IV bolus administered weekly for 4 out of 6 weeks.
• The XELOX regimen (capecitabine plus oxaliplatin):
  • Oral capecitabine (1,000 mg/m²) twice a day for 14 days plus oxaliplatin (130 mg/m²) on day 1 every 3 weeks.