Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Quinidine may increase the amount of loperamide that enters your brain.
What might happen:
You may have more side effects than normal from your loperamide.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know right away if you experience excessive drowsiness, deep sleep, slowed breathing, slow pulse, nausea, or vomiting.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Sadeque AJ, Wandel C, He H, Shah S, Wood AJ. Increased drug delivery to the brain by P-glycoprotein inhibition. Clin Pharmacol Ther 2000 Sep; 68(3):231-7.
2.Imodium (loperamide hydrochloride) US prescribing information. Janssen Pharmaceutica, Inc. October, 2005.