Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Fluvoxamine may slow down how quickly your liver processes olanzapine.
What might happen:
The amount of olanzapine in your blood may increase and cause more side effects than normal.
What you should do about this interaction:
Let your healthcare professional (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know if you have any severe drowsiness, slurred speech, slowed breathing, or seizures.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Chiu CC, Lane HY, Huang MC, Liu HC, Jann MW, Hon YY, Chang WH, Lu ML. Dose-dependent alternations in the pharmacokinetics of olanzapine during coadministration of fluvoxamine in patients with schizophrenia. J Clin Pharmacol 2004 Dec;44(12):1385-90.
2.Hiemke C, Peled A, Jabarin M, Hadjez J, Weigmann H, Hartter S, Modai I, Ritsner M, Silver H. Fluvoxamine augmentation of olanzapine in chronic schizophrenia: pharmacokinetic interactions and clinical effects. J Clin Psychopharmacol 2002 Oct;22(5):502-6.
3.Weigmann H, Gerek S, Zeisig A, Muller M, Hartter S, Hiemke C. Fluvoxamine but not sertraline inhibits the metabolism of olanzapine: evidence from a therapeutic drug monitoring service. Ther Drug Monit 2001 Aug;23(4):410-3.
4.Zyprexa (olanzapine) Australian prescribing information. Eli Lilly Pty Ltd November 30, 2006.
5.Zyprexa Relprevv (olanzapine ext-rel IM susp.) US prescribing information. Eli Lilly and Company March, 2013.