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Medicines That Can Cause Headache

Sometimes prescription and nonprescription medicines can cause headaches, especially if you use them regularly. Medications that may cause headaches include:

  • Birth control pills (oral contraceptive).
  • Blood-thinning medicines, such as warfarin, heparin, or aspirin.
  • Caffeine (or caffeine withdrawal).
  • Heart and blood pressure medicines, such as nitroglycerin.
  • Cold medicines, such as antihistamines and decongestants.
  • Corticosteroids, such as prednisone
  • Ergotamine (Cafergot) therapy.
  • Hormone therapy, such as estrogen or progestin.
  • Medicines to prevent organ transplant rejection.
  • Medicines used to treat cancer (chemotherapy).
  • Overuse of fat-soluble vitamins, such as vitamin A and vitamin D.
  • Radiation therapy.

Often, if you stop taking the medicine or take a smaller dose, your headache will go away. If you suspect your headache is caused by a prescription medicine, talk with your health professional about your side effects. Do not stop taking the medicine until you have spoken with your health professional.

Recommended Related to Migraines/Headaches

Understanding Migraines -- Diagnosis and Treatment

There is no specific test to diagnose a migraine headache. If you seek help from your health care provider for recurring headaches, you may be asked to keep a headache diary in which you record information about symptoms leading up to a headache, symptoms of the actual headache, and possible triggers that may have provoked the episode. Your health care provider will want to take a careful history to determine any patterns to your headaches and to learn whether such headaches run in your family....

Read the Understanding Migraines -- Diagnosis and Treatment article > >

Think about whether nonprescription medicines, alcohol, or caffeine are causing your headache. Try limiting the use of these to see if your headache goes away. Use caution with alternative therapies. Some alternative therapies may cause headaches. Talk to your health professional about any alternative therapies you are using.

Rebound headache is a type of chronic headache that can result from overuse of pain medicines. This is often a problem for people who have frequent, severe headaches. A pain medicine may work for a limited period of time, but as the effect wears off, the headache returns, often worse than it was before. The person then takes more pain medicine, the effects again wear off, and the headache returns (rebound headache). Medicines that can cause rebound headaches include:

If you think your headache may be caused by a nonprescription medicine and you feel you need to continue taking it, talk with your health professional.

By Healthwise Staff
Primary Medical Reviewer William H. Blahd, Jr., MD, FACEP - Emergency Medicine
Specialist Medical Reviewer H. Michael O'Connor, MD - Emergency Medicine
Last Revised July 2, 2010

WebMD Medical Reference from Healthwise

Last Updated: July 02, 2010
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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