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Medicines That Can Cause Headache

Many prescription and nonprescription medicines and supplements can cause headaches. A few examples are:

  • Medicines that contain hormones, such as birth control pills and hormone therapy for menopause.
  • Medicines for erection problems.
  • Caffeine (because of caffeine withdrawal).
  • Some heart and blood pressure medicines.
  • Vitamins.

Often, if you stop taking the medicine or take a smaller dose, your headache will go away. If you suspect your headache is caused by a prescription medicine, talk with your doctor about your side effects. Do not stop taking the medicine until you have spoken with your doctor.

Think about whether nonprescription medicines, alcohol, or caffeine are causing your headache. Try limiting the use of these to see if your headache goes away. Use caution with alternative therapies. Some alternative therapies may cause headaches. Talk to your doctor about any alternative therapies you are using.

Rebound headache is a type of chronic headache that can result from overuse of pain medicines. This is often a problem for people who have frequent, severe headaches. A pain medicine may work for a limited period of time, but as the effect wears off, the headache returns, often worse than it was before. The person then takes more pain medicine, the effects again wear off, and the headache returns (rebound headache). Medicines that can cause rebound headaches include:

If you think your headache may be caused by a nonprescription medicine and you feel you need to continue taking it, talk with your doctor.

ByHealthwise Staff
Primary Medical ReviewerWilliam H. Blahd, Jr., MD, FACEP - Emergency Medicine
Specialist Medical ReviewerH. Michael O'Connor, MD - Emergency Medicine
Last RevisedApril 17, 2012

WebMD Medical Reference from Healthwise

Last Updated: April 17, 2012
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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