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This article is from the WebMD News Archive
New Urine Test ID's Prostate Cancer
Nov. 28, 2006 - A new urine test can tell prostate cancer from an enlarged prostate -- but can't tell whether the cancer is deadly.
The test, from San Diego-based Gen-Probe, is approved in some European countries but not in the U.S. It detects genetic material -- RNA -- from prostate cancer gene 3 or PCA3.
PCA3 (previously known as the DD3 gene) is found only in the prostate. When prostate cells become cancerous, their PCA3 genes go wild. Prostate cancer cells express 60 to 100 times more PCA3 RNA than normal cells.
That means the PCA3 test can do things the current PSA test can't do. The PSA test detects prostate-specific antigen, a protein given off by all prostate cells. If a man has an enlarged prostate -- a noncancerous condition called benign prostatic hyperplasia or BPH -- his PSA level can go up. This often triggers unnecessary biopsies and, sometimes, unnecessary surgery.
"The beauty of this test is it seems to be independent of the BPH component," Mark Emberton, MD, of the Institute of Urology at University College London, tells WebMD. "But it is not a perfect test. It does not rule out -- or rule in -- clinically meaningful disease."
Emberton, who has no financial links to Gen-Probe, reported several studies of the PCA3 test at last week's annual meeting of the British Association of Urological Surgeons in London.
The studies showed that the PCA3 test isn't influenced by the size of the prostate, even in people with BPH. And they showed that the test can help men decide whether they need a repeat prostate biopsy. Prostate biopsy involves multiple needle punctures into the walnut-sized prostate gland.
"This test is going to be of value in two currently problematic areas," Emberton tells WebMD. "It will help men with a [relatively] low PSA who need reassurance but don't want an invasive test. And it will help men with a negative biopsy but a rising PSA decide whether they need a second set of biopsies."
Learning How to Use the Tests
The PCA3 gene was discovered by Marion Bussemakers, PhD, while she was working in the laboratory of William B. Isaacs, PhD, professor of urology and oncology at Johns Hopkins Brady Urological Institute. Isaacs is among the patent holders for the diagnostic use of the PCA3 gene.
"I am very excited by these new findings," Isaacs tells WebMD. "There is no question we need better ways to find who has prostate cancer and who needs to be treated. … [PCA3] is among the most prostate- cancer-specific markers ever identified."
If the PCA3 test is so good at detecting prostate cancer, will it replace PSA tests and prostate biopsies? No, Isaacs and Emberton say. That's because if a man lives long enough, he's very likely to develop prostate cancer.
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Indication
Uroxatral® (alfuzosin HCl 10 mg extended-release tablets) is an alpha1-blocker for the treatment of the signs and symptoms of BPH.
Important Safety Information
Do not take UROXATRAL if you have liver problems or if you are taking antifungal drugs like ketoconazole or itraconazole, or HIV drugs like ritonavir.
UROXATRAL can cause a sudden drop in blood pressure, especially when starting treatment. This may lead to fainting, dizziness, and lightheadedness. Do not drive, operate machinery, or do any dangerous activity until you know how UROXATRAL will affect you. This is especially important if you already have a problem with low blood pressure or take medicines to treat high blood pressure. There may be an increased risk of low blood pressure and fainting when taking UROXATRAL in combination with blood pressure medication or nitrates, or erectile dysfunction medication.
If considering cataract surgery (clouding of the eyes), tell your eye surgeon that you are currently taking UROXATRAL or have previously been treated with an alpha-blocker.
Before taking UROXATRAL, tell your doctor if you have kidney problems.
Also, tell your doctor if you or any family member(s) have or take medications for a rare heart condition known as congenital prolongation of the QT interval.
BPH and prostate cancer can cause the same symptoms. However, UROXATRAL is not a treatment for prostate cancer.
The most common side effects with UROXATRAL are dizziness, upper respiratory tract infection, headache, and tiredness.
Please see UROXATRAL full prescribing information.
Symptoms of an Enlarged Prostate
Sheldon Marks, MD, explains nearly everything you need to know about an enlarged prostate but were afraid to ask.
