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Diet, Drugs May Stop Prostate Cancer

Trials Poised to Identify Prevention Strategies
WebMD Health News
Reviewed by Louise Chang, MD

Sept. 24, 2007 -- How to lower cancer risk in men is one of the hottest areas in prevention research. Now a new study shows there should be some definitive answers on prostate cancer within the next few years.

A host of trials are under way investigating drug treatments, nutritional supplements, and foods that have shown promise for the prevention of prostate cancer.

Urologist and prostate cancer researcher Neil Fleshner, MD, MPH, of the University of Toronto, says these trials should soon lead to effective evidence-based strategies to prevent the disease.

Fleshner’s review of the prostate cancer prevention research appears in the latest online issue of the journal Cancer.

“There is great hope that within the next five years we will have relatively inexpensive and very effective ways to minimize the burden of prostate cancer,” he tells WebMD.

But a cancer epidemiologist who also spoke to WebMD called the five-year timeline optimistic.

“Results from these clinical trials should shed some light on what can be done, but I am doubtful that they will provide all the answers,” says Carmen Rodriguez, MD, of the American Cancer Society.

Food, Drug Strategies for Prevention

Several studies have linked the consumption of animal fat -- especially fat found in red meat and high-fat dairy products -- to an increase in prostate cancer risk.

The overall health benefits of limiting red meat and high-fat dairy foods are well-known. Fleshner says reducing prostate cancer risk may prove to be one more benefit of eating a diet high in fruits and vegetables and low in animal fat.

One of the most promising strategies for preventing prostate cancer in high-risk men had been treatment with the prostate enlargement drug finasteride (known commercially as Proscar) or similar drugs.

But a large trial of finasteride, involving close to 19,000 men who were at average risk for developing the disease, produced confusing results.

While the men in the Prostate Cancer Prevention Trial (PCPT) who took the drug had a 25% reduction in prostate cancers compared with men who didn't, they also had more advanced and aggressive tumors.

The clinical significance of both of these findings remains in doubt. It is not clear if finasteride actually promotes higher-grade tumors or if the finding was due to the study design.

But the bigger reason why the drug is not used more for prostate cancer prevention is doubt about whether it prevents cancers that lead to death, Fleshner says.

“Most doctors still have questions about whether the types of tumors prevented with finasteride are actually clinically relevant,” he says.

It is also not clear if potential side effects, such as impotence and decreased sex drive, will keep men from taking the drug for prostate cancer prevention or just who should take it if it proves beneficial, Rodriguez says.

A large clinical trial of a similar drug, Avodart, is ongoing. The trial involves more than 8,000 men at high risk for developing prostate cancer, and results are expected within the next few years.

Another approach to chemoprevention involves treatment with the antiestrogen breast cancer drug Fareston.

Early trials found that men treated with low doses of the drug (20 milligrams) developed slightly fewer prostate cancers than those treated with placebo or higher doses of Fareston. Results from a definitive study should be reported within the next two years, Fleshner says.

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