Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Font Size

Protein in Soy Traps Prostate Cancer

Genistein Stops Prostate Cancer's Spread in Mice; Human Trials Under Way
WebMD Health News
Reviewed by Louise Chang, MD

March 14, 2008 -- Dietary levels of genistein, a soy protein, stopped the spread of prostate cancer in mouse studies, Northwestern University researchers report.

Men who live in countries with high soy consumption are less likely to die of prostate cancer than are men in the U.S. and Europe. Genistein, a protein from soybeans, keeps prostate cancer cells from spreading in test-tube studies.

Now a study led by Raymond C. Bergen, MD, director of experimental therapeutics for the Robert H. Lurie Comprehensive Cancer Center at Northwestern University, shows that genistein fights human prostate cancers implanted in living animals.

The soy compound doesn't make prostate cancer go away. It doesn't even make prostate tumors smaller. But it does keep the cancer cells from spreading through the body. Like some other cancers, prostate cancer is not deadly unless it spreads through the body -- a process known as cancer metastasis.

"These impressive results give us hope that genistein might show some effect in preventing the spread of prostate cancer in patients," Bergen says in a news release. "Now we have all the preclinical studies we need to suggest genistein might be a very promising chemopreventive drug."

A 2003 human study showed that when men with prostate cancer took genistein preparations, their blood levels of genistein reached concentrations that had anticancer effects in the test tube. These are the same genistein blood levels that protected mice in the current study.

Bergan and colleagues note that a larger clinical trial of genistein is under way. Other researchers are studying the compound in patients with breast cancer, kidney cancer, endometrial cancer, pancreatic cancer, and melanoma.

Bergan and colleagues report their findings in the March 15 issue of Cancer Research.

Today on WebMD

man with doctor
Symptoms, risks, treatments
man coughing
Men shouldn’t ignore
prostate cancer cells
What does this diagnosis mean?
doctor and male patient
Is it worth it?
cancer fighting foods
15 Cancer Symptoms Men Ignore
Prostate Enlarged
Picture Of The Prostate
Prostate Cancer Quiz
screening tests for men
Prostate Cancer Symptoms
Vitamin D