New Drug Helps Slow Prostate Cancer
Study Shows Abiraterone Is Effective Against Hard-to-Treat Tumors
WebMD News Archive
Feb. 27, 2009 (Orlando, Fla.) -- An experimental pill that blocks the
production of male hormones that fuel prostate cancer may help slow the growth
of hard-to-treat tumors.
The novel agent, called abiraterone, shrank tumors by 30% or more in
one-fourth of 31 patients whose prostate cancer continued to spread despite
standard hormone therapy. In an additional 35% of men, tumors stopped
"A few patients are still alive, without any signs of progression, more
than a year after therapy began," says researcher Charles J. Ryan, MD, a
cancer specialist at the University of California, San Francisco.
Without the new drug, they would have only been expected to live three or
four months, he tells WebMD.
The researchers also used PSA levels to evaluate abiraterone's
effectiveness. PSA levels are a measure of a protein called prostate-specific
antigen, which is produced by cells in the prostate. High PSA levels can signal
cancer. The National Cancer Institute views a response to treatment as being
seen when there is at least a 50% decline in PSA blood level.
After 12 weeks of treatment, abiraterone reduced PSA levels by 50% or more
in 71% of the men. In two men, PSA fell to undetectable levels.
Ryan presented the results here at the 2009 Genitourinary Cancers
Symposium. The meeting is co-sponsored by the American Society of
Clinical Oncology (ASCO) and two other cancer care organizations.
How Abiraterone Works
"This is currently the most promising prostate cancer drug on the
horizon," says ASCO spokesman Howard Sandler, MD, chairman of radiation
oncology at the Samuel Oschin Cancer Institute at Cedars-Sinai Medical Center
in Los Angeles.
"Here's a novel therapy hormone that seems to be active in men thought
to be unresponsive to hormone therapy," he tells WebMD.
That may be because abiraterone works differently than other hormone
Prostate cancer grows when exposed to the male hormone testosterone and its
related hormones, called androgens. Hormone treatment is given to halt the
production of testosterone and androgens.
Current treatments -- surgical removal of the testes or medication --
prevent the production of male hormones in the testes. But these approaches do
not prevent other parts of the body from making male hormones. Abiraterone
targets an enzyme called CYP17 that is necessary for the production of male
hormones throughout the body.