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Drug May Help Men With Advanced Prostate Cancer

Study participants hadn't received any treatment with chemotherapy

WebMD News from HealthDay

By Serena Gordon

HealthDay Reporter

TUESDAY, Jan. 28, 2014 (HealthDay News) -- A new hormone therapy drug for men with prostate cancer may increase survival a bit and delay progression of the disease in men who have advanced prostate cancer that has been resistant to standard hormonal therapies, a new study suggests.

The study found that the drug enzalutamide increased survival by 29 percent and delayed disease progression by 81 percent in men who hadn't received any treatment with chemotherapy.

"There's new hope for men with very advanced prostate cancer," said study author Dr. Tomasz Beer, deputy director of the Knight Cancer Institute at Oregon Health and Science University in Portland. "This is a treatment with an excellent safety profile that can help men maintain quality of life and extend disease-free progression and extend survival."

The findings are scheduled to be presented Thursday at a meeting of the American Society of Clinical Oncologists, in San Francisco. The study authors reported receiving research funding from the drug's manufacturers.

The U.S. Food and Drug Administration approved enzalutamide in 2012 for use in men with advanced prostate cancer who have received chemotherapy. The drug is a type of hormone therapy called an androgen receptor blocker. Androgens are male hormones.

Enzalutamide is considered a second-generation hormone therapy. First-generation hormone therapy drugs for prostate cancer include bicalutamide, flutamide and nilutamide.

The current study included more than 1,700 men with prostate cancer that had spread to other areas of their bodies. The men's cancer also had progressed despite treatment with other types of hormone therapy. None of these men had yet been treated with chemotherapy. They had, however, been treated with surgery and radiation therapy.

Half of the volunteers were randomly assigned to receive enzalutamide and the other half received a placebo.

The study was stopped early because it was clear that enzalutamide offered a benefit over a placebo, so the drug was offered to all of the study volunteers.

"There was an 81 percent reduction in the risk of disease progression for men on enzalutamide," Beer said. "The median time to disease progression in placebo was [about four] months, but on the drug, a median time to disease progression hasn't been reached despite 20 months of follow-up."

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