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    Neuroleptic Malignant Syndrome

    Important
    It is possible that the main title of the report Neuroleptic Malignant Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

    Synonyms

    • Drug-Induced Movement Disorder
    • Neuroleptic-Induced Acute Dystonia
    • Hyperthermia

    Disorder Subdivisions

    • None

    General Discussion

    Neuroleptic malignant syndrome is a rare but potentially life-threatening reaction to the use of almost any of a group of antipsychotic drugs or major tranquilizers (neuroleptics). These drugs are commonly prescribed for the treatment of schizophrenia and other neurological, mental, or emotional disorders. Several of the more commonly prescribed neuroleptics include thioridazine, haloperidol, chlorpromazine, fluphenazine and perphenazine.

    The syndrome is characterized by high fever, stiffness of the muscles, altered mental status (paranoid behavior), and autonomic dysfunction. Autonomic dysfunction alludes to defective operations of the components of the involuntary (autonomic) nervous system, leading to wide swings of blood pressure, excessive sweating and excessive secretion of saliva.

    A genetic basis for the disorder is suspected but not proven. It does appear to be clear that a defect in the receptors to dopamine (dopamine D2 receptor antagonism) is an important contributor to the cause of neuroleptic malignant syndrome.

    Resources

    Malignant Hyperthermia Association of the United States
    1 North Main St
    PO Box 1069
    Sherburne, NY 13460
    USA
    Tel: (607)674-7901
    Fax: (607)674-7910
    Email: info@mhaus.org
    Internet: http://www.mhaus.org

    North American Malignant Hyperthermia Registry
    Penn State University
    Dept. of Anesthesiology
    P.O. Box 850
    Hershey, PA 17033-0850
    USA
    Tel: (412)692-6390
    Fax: (412)692-8658
    Tel: (888)274-7899
    Email: bwb@pitt.edu
    Internet: http://www.mhreg.org

    National Mental Health Consumers' Self-Help Clearinghouse
    1211 Chestnut Street
    Suite 1207
    Philadelphia, PA 19107-6312
    USA
    Tel: (215)751-1810
    Fax: (215)636-6312
    Tel: (800)553-4539
    Email: info@mhselfhelp.org
    Internet: http://www.mhselfhelp.org

    Mental Health America
    2000 N. Beauregard Street, 6th Floor
    Alexandria, VA 22314-2971
    USA
    Tel: (703)684-7722
    Fax: (703)684-5968
    Tel: (800)969-6642
    TDD: (800)433-5959
    Email: infoctr@mentalhealthamerica.net
    Internet: http://www.mentalhealthamerica.net/

    National Alliance on Mental Illness
    3803 N. Fairfax Drive
    Suite 100
    Arlington, VA 22203-
    Tel: (703)524-7600
    Fax: (703)524-9094
    Tel: (800)999-6264
    TDD: (703)516-7227
    Email: membership@nami.org
    Internet: http://www.nami.org

    NIH/National Institute of Mental Health
    Health Science Writing, Press and Dissemination Branch
    6001 Executive Boulevard
    Room 8184, MSC 9663
    Bethesda, MD 20892-9663
    Tel: (301)443-4513
    Fax: (301)443-4279
    Tel: (866)615-6464
    TDD: (301)443-8431
    Email: nimhinfo@nih.gov
    Internet: http://www.nimh.nih.gov/index.shtml

    MedicAlert Foundation International
    2323 Colorado Avenue
    Turlock, CA 95382
    USA
    Tel: (209)669-2401
    Fax: (209)669-2456
    Tel: (888)633-4298
    Email: Inquiries@medicalert.org
    Internet: http://www.medicalert.org

    For a Complete Report:

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

    Last Updated: 5/1/2008
    Copyright 1990, 1995, 2004 National Organization for Rare Disorders, Inc.

    WebMD Medical Reference from the National Organization for Rare Disorders

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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