Which Medications Treat Schizophrenia?

If you have a loved one with schizophrenia, you want them to get help as quickly as possible. Medication is key, along with other types of care, such as psychotherapy, which is a kind of talk therapy, and social skills training.

But you have to be sure your family member takes their medication. And that’s not always easy. Schizophrenia is a mental disorder that affects how a person acts, thinks, and feels. It can keep them from seeing the world in a normal way, which means they may not want to take their medication.

Schizophrenia causes many symptoms, including:

  • Delusions (believing things that aren’t true)
  • Hallucinations (seeing or hearing things that aren’t there)
  • Jumbled or confused thinking and speaking
  • Odd and random movements like strange posture

Doctors aren’t sure exactly what causes schizophrenia. There is no cure. So to treat it, a doctor will prescribe your loved one medications that can help ease their symptoms and prevent them from coming back.

Antipsychotics: Medications That Tame Psychosis

The medications doctors prescribe most often for schizophrenia are called antipsychotics. They ease symptoms such as delusions and hallucinations.

These drugs work on chemicals in the brain such as dopamine and serotonin.

Your loved one will most likely have to take schizophrenia medication their entire life, even if their symptoms get better. They can take antipsychotics as a liquid, a pill, or as an injection.

If you think they might have trouble remembering to take medicine every day, they can try a shot they get from their doctor once or twice a month called a long-acting injectable antipsychotic medication (LAI). It works just as well as taking a daily pill.

Doctors will choose which medication is best by looking at the following:

  • How well it works on their symptoms
  • How much it will cost
  • Side effects
  • How easily they can get it
  • How often they have to take it


Types of Antipsychotic Medications

There are two groups of antipsychotics. Doctors call the older group of medications “first-generation,” “typical,” or “conventional” antipsychotics. Some common ones are:

The newer ones are called “second-generation,” or “atypical” antipsychotics. Examples of these medicines include:

Note: Clozapine is the only FDA-approved medication for treating schizophrenia that is resistant to other treatments. It’s also

Side Effects of Antipsychotics

While the first-generation, older meds usually cost less, they can have different side effects than the newer antipsychotics. Some can cause higher levels of the hormone prolactin. This can affect sex drive, mood, menstrual cycles, and growth of breast tissue in both men and women.

One of the common side effects of many of the newer antipsychotics is weight gain. Your loved one may also have trouble keeping their blood sugar and cholesterol levels under control.

One of the more serious side effects from long-term use of both the older and newer medications is a movement disorder called tardive dyskinesia. It makes your facial, tongue, and neck muscles move uncontrollably and can be permanent.

While both older and newer antipsychotics can cause tardive dyskinesia, researchers believe that the odds are higher with the older antipsychotics.

Antipsychotics come with other side effects as well. Your loved one could have any of the following:

Be sure they see their doctor regularly while they are taking antipsychotic medication. And encourage them to talk to their doctor if they have any concerns about side effects.

Medication and Support

Schizophrenia can make it hard to stick to a medication plan. Your loved one will need a strong support system.

Learn as much as you can about schizophrenia and be part of the decision-making process with your loved one’s doctor. Surrounding them with people who care about their well-being is also key.

When they start to take their medication, they may feel better right away. But it may take up to 4 to 6 weeks before symptoms like hallucinations and delusions get better.

Be sure they keep taking it long enough for their doctor to know if it’s working. Sometimes it can take several tries to find out which medication works best.

WebMD Medical Reference Reviewed by Smitha Bhandari, MD on January 21, 2020



Mayo Clinic: “Schizophrenia.”

National Institute of Mental Health: “Schizophrenia,” “Mental Health Medications.”

Medscape: “Schizophrenia Treatment & Management.”

National Alliance on Mental Illness: “Mental Health Medications.”

First- and Second-Generation Antipsychotics for Children and Young Adults, Agency for Healthcare Research and Quality, 2012.


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