Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier
WebMD

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine
WebMD

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion
    WebMD

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community
    WebMD

    Community

    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Schizophrenia Health Center

Font Size
A
A
A

2 Schizophrenia Drugs Square Off

Zyprexa Found More Effective, but Expert Has Concerns
By
WebMD Health News

April 7, 2003 -- In a head-to-head comparison of two popular schizophrenia drugs, a new study shows that the most commonly used drug proved to be more effective. But one expert has concerns over Zyprexa's potential long-term side effects.

The study, presented this week at the International Congress on Schizophrenia Research, shows that patients fared better when treated with Zyprexa. That medication was compared with Geodon in 548 people with schizophrenia. Study participants did not know which schizophrenia drug they were getting.

Specifically, the study shows that nearly 60% of patients responded favorably to Zyprexa, compared with 42% treated with Geodon -- having fewer delusions and hallucinations and fewer symptoms of depression. Patients on Zyprexa were also less likely to require additional medications to treat agitation and anxiety or control tremors.

For those who responded to one of the schizophrenia drugs, those taking Zyprexa were less likely to have a relapse throughout the 28-week study. The Zyprexa group was also half as likely to stop taking their schizophrenia drug.

The study was sponsored by Zyprexa manufacturer Eli Lilly and Co., a WebMD sponsor.

"When a patient drops out, it's usually because of side effects, a lack of efficacy, or their psychosis gets worse," says psychiatrist David Garver, MD, of the University of Louisville School of Medicine. "Although the side effects were roughly the same, nearly twice as many patients in the Geodon group dropped out from the study compared to those treated with Zyprexa."

Garver, a spokesman for the American Psychiatric Association, was not involved in the study but he did attend the conference presentation. In his experience, he says both drugs are effective.

"I haven't seen very much of a clinical difference between the two, and it's barely detectable from a practical point of view. But when you get a large number of patients like in this study, the small differences really add up," he tells WebMD. "Overall, this is a good study and demonstrates some further improvement from Zyprexa."

Still, he has his concerns of potential long-term side effects of this schizophrenia drug. "Zyprexa does a beautiful job on the short-term, but it causes the development of diabetes in many patients and raises cholesterol and triglyceride levels," he says. "Unfortunately, these are effects you don't see for years and wouldn't be detected during the course of this study."

Today on WebMD

69X75_Depression.jpg
Article
Mental Health Psychotic Disorders
Article
 
Schizophrenia Medications
Article
bored man resting chin on hands
Article
 
vincent van gogh
Article
paranoia
Slideshow
 
Schizophrenia What Increases Your Risk
Article
mother and daughter
Article
 
boy hiding under blanket
Article
male patient with doctor
Article
 
romantic couple
Article
businesswoman working at desk at night
Article