Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier
WebMD

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine
WebMD

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion
    WebMD

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community
    WebMD

    Community

    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Schizophrenia Health Center

Font Size
A
A
A

2 Schizophrenia Drugs Square Off

Zyprexa Found More Effective, but Expert Has Concerns

continued...

In fact, Garver tells WebMD that in Japan, Zyprexa is packaged with special warnings because of these risks. It, along with some other schizophrenia drugs, is also known to cause weight gain, which was seen in 13% of the Zyprexa group, compared with only 2% of those taking Geodon. Both drugs were prescribed to these patients in their usual doses.

"Frankly, although this study gives an edge to Zyprexa, I think what most psychiatrists are concerned about is the ultimate effect of these drugs," says Garver, who has served as a consultant for both Lilly and Pfizer, which manufactures Geodon. "And Geodon doesn't cause these long-term side effects."

In some patients, however, Geodon can slow electrical conduction through the heart, causing an irregular heartbeat and decreasing pumping action -- an effect not known to be caused by Zyprexa. In this study, Geodon patients were also three times more likely to have insomnia and twice as likely to experience vomiting.

Both drugs are called "atypical antipsychotic" medications, the newest class of schizophrenia drugs, which are believed to cause less restlessness and fewer muscle spasms and other movement disorders commonly associated with older schizophrenia drugs. Other drugs in this new class include Clozaril, Risperdal, and Seroquel, which were not evaluated in this study.

Schizophrenia drugs work by blocking the action of serotonin and dopamine, two brain chemicals that are altered in those with schizophrenia. Affecting more than 2 million Americans in any given year, according to the National Institute of Mental Health, the disease is characterized by hearing voices and believing that other people or forces are reading their minds, controlling their thoughts, or trying to harm them. Although schizophrenia drugs can control these symptoms, it's estimated that no more than one in five patients ever completely recovers from schizophrenia.

1 | 2

Today on WebMD

69X75_Depression.jpg
Article
Mental Health Psychotic Disorders
Article
 
Schizophrenia Medications
Article
bored man resting chin on hands
Article
 
vincent van gogh
Article
paranoia
Slideshow
 
Schizophrenia What Increases Your Risk
Article
mother and daughter
Article
 
boy hiding under blanket
Article
male patient with doctor
Article
 
romantic couple
Article
businesswoman working at desk at night
Article