In a study of more than 250 older people with insomnia, the new sleeping pill, called Estorra, significantly reduced the amount of time they lie awake in bed, reports W. Vaughn McCall, MD, professor and chairman of the department of psychiatry and behavioral medicine at Wake Forest University Baptist Medical Center in Winston-Salem, N.C.
But the big benefit is its ability to prevent people from waking up once they have gone to bed, McCall tells WebMD.
"Young people have more trouble falling asleep but once asleep, will stay asleep," he explains. "But as you get older, there's a tendency to have more and more trouble with nighttime awakenings."
That's where Estorra, which McCall predicts could be on the market by early fall, comes in. Estorra's maker, Sepracor Inc., funded the study.
Less Tossing and Turning
Speaking here Thursday at the annual meeting of the American Psychiatric Association, McCall says that the drug shaved about 40 miserable minutes off the amount of time that elderly people with insomnia spent tossing and turning at night.
For the study, the researchers randomly assigned 265 people with insomnia, aged 65 to 85, to either Estorra or a placebo. At the start of the study, studies in a sleep lab showed patients lie awake an average of over 1.5 hours each night.
By two weeks later, those who were taking Estorra were tossing and turning an average of only one hour, compared with 73 minutes for those on placebo, McCall says.
There were other benefits too. Before the study began, it took about 45 minutes for the patients to fall asleep. Two weeks later, those given Estorra were dozing off in an average of 15 minutes, compared with a half hour for those taking the placebo, he says. Patients on Estorra also napped less and were more alert during the day.
Though McCall explains an equal number of patients in both groups suffered side effects such as headaches he says Estorra is "quite safe."