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Vitamins & Supplements

SULFORAPHANE

Other Names:

Glucosinolate de Sulforaphane, SFN, Sulforafane, Sulforaphane Glucosinolate, Sulforofano, Sulphoraphane, 1-isothiocayanate-4-methyl-sulfonyl butane.

Review this Treatment 3 User Reviews See Brand Products

SULFORAPHANE Overview Information

Sulforaphane is a chemical found in certain kinds of vegetables such as broccoli, cabbage, and cauliflower.

Sulforaphane is used for the prevention of prostate cancer and other types of cancer.

How does it work?

Sulforaphane may increase the death of cancer cells.

SULFORAPHANE Uses & Effectiveness

Insufficient Evidence for:

Preventing cancer.
Other conditions.

More evidence is needed to rate the effectiveness of sulforaphane for these uses.

SULFORAPHANE Side Effects & Safety

Sulforaphane is safe when used in the amounts found in foods. But there isn't enough information available to know if it is safe to take by mouth as a medicine.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Sulforaphane is safe in amounts found in food, but there's not enough information to know if it's safe in the larger amounts that are used as medicine.

SULFORAPHANE Interactions

Moderate Interaction Be cautious with this combination

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with SULFORAPHANE
Some medications are changed and broken down by the liver.
Sulforaphane might decrease how quickly the liver breaks down some medications. Taking sulforaphane along with some medications that are changed by the liver might increase the effects and side effects of some medications. Before taking sulforaphane talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.

SULFORAPHANE Dosing

The appropriate dose of sulforaphane depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for sulforaphane. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View clinical references for this vitamin or supplement Sources

References:

Barcelo S, Mace K, Pfeifer AM, Chipman JK. Production of DNA strand breaks by N-nitrosodimethylamine and 2-amino-3-methylimidazo[4,5-f]quinoline in THLE cells expressing human CYP isoenzymes and inhibition by sulforaphane. Mutat Res 1998;402:111-20.

Brooks JD, Paton V. Potent induction of carcinogen defense enzymes with sulforaphane, a putative prostate cancer chemopreventive agent. Prostate Cancer Prostatic Dis 1999;2:S8.

Chiao JW, Chung FL, Kancherla R, et al. Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells. Int J Oncol 2002;20:631-6.

Conaway CC, Getahun SM, Liebes LL, et al. Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli. Nutr Cancer 2000;38:168-78.

Heiss E, Herhaus C, Klimo K, et al. Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J Biol Chem 2001;276:32008-15.

Hintze KJ, Keck AS, Finley JW, Jeffery EH. Induction of hepatic thioredoxin reductase activity by sulforaphane, both in Hepa1c1c7 cells and in male Fisher 344 rats. J Nutr Biochem 2003;14:173-9.

Nestle M. Broccoli sprouts in cancer prevention. Nutr Rev 1998;56:127-30.

Park EJ, Pezzuto JM. Botanicals in cancer chemoprevention. Cancer Metastasis Rev 2002;21:231-55.

Vermeulen M, van Rooijen HJ, Vaes WH. Analysis of isothiocyanate mercapturic acids in urine: a biomarker for cruciferous vegetable intake. J Agric Food Chem 2003;51:3554-9.

Wu L, Noyan Ashraf MH, Facci M, et al. Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system. Proc Natl Acad Sci U S A 2004;101:7094-9.

Zhang J, Svehlikova V, Bao Y, et al. Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. Carcinogenesis 2003;24:497-503.

Zhang Y, Callaway EC. High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate. Biochem J 2002;364:301-7.

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Related to SULFORAPHANE

Learn about User Reviews and read IMPORTANT information about user generated content

Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health acre professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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