Skip to content

Find a Vitamin or Supplement

THREONINE

Other Names:

L-threonine, L-thréonine, Thréonine, Treonina.

THREONINE Overview
THREONINE Uses
THREONINE Side Effects
THREONINE Interactions
THREONINE Dosing
THREONINE Overview Information

Threonine is an amino acid. Amino acids are the building blocks the body uses to make proteins.

Threonine is used to treat various nervous system disorders including spinal spasticity, multiple sclerosis, familial spastic paraparesis, and amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease).

How does it work?

Threonine is changed in the body to a chemical called glycine. Glycine works in the brain to reduce constant and unwanted muscle contractions (spasticity).

THREONINE Uses & Effectiveness What is this?

Possibly Effective for:

  • Spinal spasticity, a movement disorder caused by spinal cord damage. Taking 6 grams of threonine daily seems to modestly decrease muscle contractions.

Possibly Ineffective for:

  • Amyotrophic lateral sclerosis (Lou Gehrig's disease). Taking 2 grams to 4 grams of threonine daily for up to 12 months does not seem to slow the progression of ALS or reduce symptoms. There is also some evidence that threonine might actually worsen lung function in these patients.

Insufficient Evidence for:

  • Familial spastic paraparesis, a hereditary disorder. Developing evidence suggests that taking 4.5 grams to 6 grams of threonine daily might improve some symptoms. But the improvement does not seem to be very significant.
  • Multiple sclerosis.
  • Other conditions.
More evidence is needed to rate the effectiveness of threonine for these uses.


THREONINE Side Effects & Safety

Threonine seems to be safe when doses of 2 grams to 4 grams daily are taken for up to 12 months. Some people experience minor side effects such as stomach upset, headache, nausea, and skinrash.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of threonine during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Amyotrophic lateral sclerosis (Lou Gehrig's disease): There is some concern that threonine might decrease lung function in patients with ALS. In one study, ALS patients taking 4 grams of threonine per day had significantly reduced lung function compared to patients who did not receive threonine. But more evidence is needed to determine if threonine was actually at fault.

THREONINE Interactions What is this?

Major Interaction Do not take this combination

  • Medications used for Alzheimer's disease (NMDA antagonists) interacts with THREONINE

    There is some concern that threonine might decrease how well a medication used for Alzheimer's disease works. This medication is called memantine (Namenda).


THREONINE Dosing

The following doses have been studied in scientific research:

BY MOUTH:

  • For a certain movement disorder due to spinal cord damage (spinal spasticity): 6 grams of threonine per day.

Be the first to share your experience with this treatment.

Review this Treatment

Learn about User Reviews and read IMPORTANT information about user generated content

Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

Search for a Vitamin or Supplement

Ex. Ginseng, Vitamin C, Depression

Today on WebMD

Woman taking a vitamin or supplement
Article
Man taking a vitamin or supplement
Article
 
clams
Quiz
Woman in sun
Slideshow
 
Flaxseed added fiber
Video
!!69X75_Vitamins_Supplements.jpg
Evaluator
 
Woman sleeping
Article
Woman staring into space with coffee
Article
 
IMPORTANT: About This Section and Other User-Generated Content on WebMD

The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Some of these opinions may contain information about treatment or uses of drug products that have not been approved by the U.S. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment.

Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.