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BERBERINE

Other Names:

Alcaloïde de Berbérine, Berberina, Berbérine, Berberine Alkaloid, Berberine Complex, Berberine Sulfate, Sulfate de Berbérine.

BERBERINE Overview
BERBERINE Uses
BERBERINE Side Effects
BERBERINE Interactions
BERBERINE Dosing
BERBERINE Overview Information

Berberine is a chemical found in several plants including European barberry, goldenseal, goldthread, Oregon grape, phellodendron, and tree tumeric.

People take berberine for heart failure.

Some people apply berberine directly to the skin to treat burns and to the eye to treat trachoma, a bacterial infection that frequently causes blindness.

How does it work?

Berberine might cause stronger heartbeats. It also might also be able to kill bacteria.

BERBERINE Uses & Effectiveness What is this?

Possibly Effective for:

  • Diabetes. Berberine seems to slightly reduce blood sugar levels in people with diabetes. Also, some early research suggests that taking 500 mg of berberine 2-3 times daily for up to 3 months might control blood sugar as effectively as metformin or rosiglitazone.
  • High cholesterol. There is early evidence that berberine can help lower cholesterol levels in people with high cholesterol. Taking 500 mg of berberine twice daily for 3 months seems to reduce total cholesterol, low-density lipoprotein (LDL or “bad”) cholesterol, and triglyceride levels in people with high cholesterol.

Ineffective for:

  • Heart failure, burns, trachoma (an eye infection that can cause blindness), and other conditions.

Insufficient Evidence for:

  • Burns. Early research suggests that applying an ointment that contains berberine and beta-sitosterol can treat second-degree burns as effectively as conventional treatment with silver sulfadiazine.
  • Congestive heart failure (CHF). Early research suggests that berberine can reduce some of the symptoms and lower the death rate in some people with congestive heart failure.
  • Diarrhea. Some early research suggests that berberine sulfate can decrease diarrhea in people with certain bacterial infections. Also, berberine hydrochloride seems to speed up recovery time for people with diarrhea when added to some standard treatments. However, berberine does not seem to enhance the effects of tetracycline in treating diarrhea related to cholera infection.
  • Glaucoma. Early research suggests that using eye drops containing berberine and tetrahydrozoline for 3 days does not reduce eye pressure in people with glaucoma better than eye drops containing tetrahydrozoline alone.
  • Stomach ulcers caused by Helicobacter pylori (H pylori) infection. Early research suggests that taking berberine three times daily for 6 weeks is more effective than the drug ranitidine at eliminating H. pylori infection, but less effective at healing ulcers in people with stomach ulcers due to H. pylori.
  • Hepatitis. Early research suggests that taking berberine daily for 2 months decreases blood sugar, triglycerides, and markers of liver damage in people with diabetes and hepatitis B or C.
  • Liver disease. Early research suggests that taking berberine for 12 weeks reduces fat in the blood and markers of liver damage in people with liver disease and diabetes.
  • Menopausal symptoms. Early research suggests that taking berberine and soy isoflavones can reduce menopausal symptoms.
  • Metabolic syndrome. Taking a combination product (Armolipid Plus) containing berberine, policosanol, and red yeast rice might improve blood pressure and blood flow in people with metabolic syndrome.
  • Obesity. Early research suggests that taking berberine for 12 weeks can reduce weight in obese people by about 5 pounds.
  • Osteoporosis. Early research suggests that taking berberine together with vitamin D3, vitamin K, and a chemical found in hops for 14 weeks can decrease bone loss in postmenopausal women with osteoporosis.
  • An ovary disorder known as polycystic ovary syndrome (PCOS). Early research suggests that berberine can reduce blood sugar, cholesterol, triglycerides, testosterone, and waist-to-hip ratio in women with PCOS.
  • Injuries caused by radiation. Some early research suggests that taking berberine during radiation therapy can reduce the occurrence and severity of some injuries caused by radiation in patients being treated for cancer.
  • Low blood platelet counts (thrombocytopenia). Blood platelets are important for blood clotting. Early research suggests that taking berberine for 15 days, either alone or with prednisolone, can increase the number of blood platelets in people with low blood platelet counts.
  • Trachoma. There is some evidence that eye drops containing berberine might be useful for treating trachoma, a common cause of blindness in developing countries.
  • Other conditions.
More evidence is needed to rate the effectiveness of berberine for these uses.


BERBERINE Side Effects & Safety

Berberine is POSSIBLY SAFE for most adults for short-term use when taken by mouth or applied to the skin.

Special Precautions & Warnings:

Children: It’s UNSAFE to give berberine to newborns. It can cause kernicterus, a rare type of brain damage that can occur in newborns who have severe jaundice. Jaundice is yellowing of the skin caused by too much bilirubin in the blood. Bilirubin is a chemical that is produced when the old red cells break down. It is normally removed by the liver. Berberine may keep the liver from removing bilirubin fast enough.

Pregnancy and breast-feeding: It’s UNSAFE to take berberine by mouth if you are pregnant. Researchers believe berberine can cross the placenta and might cause harm to the fetus. Kernicterus, a type of brain damage, has developed in newborn infants exposed to berberine.

It’s also UNSAFE to take berberine if you are breast-feeding. Berberine can be transferred to the infant through breast milk, and it might cause harm.

Diabetes: Berberine can lower blood sugar. Theoretically, berberine may cause blood sugar to become too low if taken by diabetics who are controlling their blood sugar with insulin or medications. Use with caution in people with diabetes.

High bilirubin levels in the blood in infants: Bilirubin is a chemical that is produced when the old red blood cells break down. It is normally removed by the liver. Berberine may keep the liver from removing bilirubin fast enough. This can cause brain problems, especially in infants with high levels of bilirubin in the blood. Avoid using.

Low blood pressure: Berberine might lower blood pressure. Use with caution in people with low blood pressure.

BERBERINE Interactions What is this?

Major Interaction Do not take this combination

  • Cyclosporine (Neoral, Sandimmune) interacts with BERBERINE

    The body breaks down cyclosporine (Neoral, Sandimmune) to get rid of it. Berberine might decrease how fast the body breaks down cyclosporine (Neoral, Sandimmune). This might cause there to be too much cyclosporine (Neoral, Sandimmune) in the body and potentially cause side effects.


Moderate Interaction Be cautious with this combination

  • Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with BERBERINE

    Some medications are changed and broken down by the liver.
    Berberine might decrease how quickly the liver breaks down some medications. Taking berberine along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking berberine, talk to your healthcare provider if you are taking any medications that are changed by the liver.
    Some medications changed by the liver include cyclosporin (Neoral, Sandimmune), lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and many others.


BERBERINE Dosing

The appropriate dose of berberine depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for berberine. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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