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BISHOP'S WEED

Other Names:

Ajava Seeds, Ajowan, Ajowan Caraway, Ajowan Seed, Ajowanj, Ajwain, Ajwan, Ameo Bastardo, Ammi Commun, Ammi Élevé, Ammi glaucifolium, Ammi Inodore, Ammi majus, Ammi Officinal, Bishop's Flower, Bisnague, Bullwort, Carum, Espuma del Mar, Flowering ...
See All Names

BISHOP'S WEED Overview
BISHOP'S WEED Uses
BISHOP'S WEED Side Effects
BISHOP'S WEED Interactions
BISHOP'S WEED Dosing
BISHOP'S WEED Overview Information

Bishop's weed is a plant. The seeds are used to make medicine.

The prescription drug methoxsalen (Oxsoralen, Methoxypsoralen) was originally prepared from bishop's weed, but it is now made in the laboratory. Methoxsalen is used to treat psoriasis, a skin condition.

Bishop's weed is used for digestive disorders, asthma, chest pain (angina), kidney stones, and fluid retention.

Some people apply bishop's weed directly to the skin for skin conditions including psoriasis and vitiligo.

Be careful not to confuse bishop’s weed (Ammi majus) with its more commonly used relative, khella (Ammi visnaga). The two species do contain some of the same chemicals and have some similar effects in the body. But Bishop's weed is more commonly used for skin conditions, and khella is usually used for heart and lung conditions.

How does it work?

Bishop's weed contains several chemicals, including methoxsalen, a chemical used to make a prescription medication for the skin condition psoriasis.

BISHOP'S WEED Uses & Effectiveness What is this?

Insufficient Evidence for:

  • Skin conditions such as psoriasis and vitiligo.
  • Digestive problems.
  • Asthma.
  • Chest pain.
  • Kidney stones.
  • Fluid retention.
  • Other conditions.
More evidence is needed to rate the effectiveness of bishop’s weed for these uses.


BISHOP'S WEED Side Effects & Safety

There isn't enough information to know if bishop's weed is safe. When taken by mouth, bishop's weed might cause nausea, vomiting, and headache. Some people are allergic to bishop's weed. They can get a runny nose, rash, or hives. There is also some concern that bishop's weed might harm the liver or the retina of the eye.

Bishop's weed can cause skin to become extra sensitive to the sun. This might put you at greater risk for skin cancer. Wear sunblock outside, especially if you are light-skinned.

Special Precautions & Warnings:

Pregnancy and breast-feeding: It’s UNSAFE to use bishop’s weed if you are pregnant. It contains a chemical called khellin that can cause the uterus to contract, and this might threaten the pregnancy.

It’s also best to avoid using bishop’s weed if you are breast-feeding. There isn’t enough information to know whether it is safe for a nursing infant.

Liver disease: There is some evidence that bishop’s weed might make liver disease worse.

Surgery: Bishop's weed might slow blood clotting. There is a concern that it might increase the risk of bleeding during and after surgery. Stop using bishop’s weed at least 2 weeks before a scheduled surgery.

BISHOP'S WEED Interactions What is this?

Moderate Interaction Be cautious with this combination

  • Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with BISHOP'S WEED

    Some medications are changed and broken down by the liver.
    Bishop's weed might decrease how quickly the liver breaks down some medications. Taking Bishop's weed along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking Bishop's weed, talk to your healthcare provider if you are taking any medications that are changed by the liver.
    Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.

  • Medications that can harm the liver (Hepatotoxic drugs) interacts with BISHOP'S WEED

    Bishop's weed might harm the liver. Taking bishop's weed along with medication that might also harm the liver can increase the risk of liver damage. Do not take bishop's weed if you are taking a medication that can harm the liver.
    Some medications that can harm the liver include acetaminophen (Tylenol and others), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), fluconazole (Diflucan), itraconazole (Sporanox), erythromycin (Erythrocin, Ilosone, others), phenytoin (Dilantin), lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), and many others.

  • Medications that increase sensitivity to sunlight (Photosensitizing drugs) interacts with BISHOP'S WEED

    Some medications can increase sensitivity to sunlight. Bishop's weed might also increase your sensitivity to sunlight. Taking bishop's weed along with medication that increases sensitivity to sunlight could increase the chances of sunburn, blistering or rashes on areas of skin exposed to sunlight. Be sure to wear sunblock and protective clothing when spending time in the sun.
    Some drugs that cause photosensitivity include amitriptyline (Elavil), Ciprofloxacin (Cipro), norfloxacin (Noroxin), lomefloxacin (Maxaquin), ofloxacin (Floxin), levofloxacin (Levaquin), sparfloxacin (Zagam), gatifloxacin (Tequin), moxifloxacin (Avelox), trimethoprim/sulfamethoxazole (Septra), tetracycline, methoxsalen (8-methoxypsoralen, 8-MOP, Oxsoralen), and Trioxsalen (Trisoralen).

  • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with BISHOP'S WEED

    Bishop's weed might slow blood clotting. Taking bishop's weed along with medications that also slow clotting might increase the chances of bruising and bleeding.
    Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.


BISHOP'S WEED Dosing

The appropriate dose of bishop's weed depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for bishop's weed. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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