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Other Names:

Common Periwinkle, Earlyflowering, Evergreen, Herbe à la Capucine, Herbe de Fidélité, Lesser Periwinkle, Myrtle, Petite Pervenche, Pervenche Mineure, Small Periwinkle, Vinca minor, Vincae Minoris Herba, Vincapervinca, Violette des Morts, Violett...
See All Names

PERIWINKLE Interactions
PERIWINKLE Overview Information

Periwinkle is an herb. The parts that grow above the ground are used to make medicine. Don’t confuse periwinkle with Madagascar periwinkle (Catharanthus roseus).

Despite serious safety concerns, periwinkle is used for “brain health” (increasing blood circulation in the brain, supporting brainmetabolism, increasing mental productivity, preventing memory and concentration problems and feebleness, improving memory and thinking ability, and preventing early aging of brain cells).

Periwinkle is also used for treating diarrhea, vaginal discharge, throat ailments, tonsillitis, chest pain, high blood pressure, sore throat, intestinal pain and swelling (inflammation), toothache, and water retention (edema). It is also used for promoting wound healing, improving the way the immune system defends the body, and for “blood-purification.”

A chemical in periwinkle called vincamine can be converted in the laboratory to the compound vinpocetine, which is marketed as a dietary supplement.

How does it work?

Periwinkle can lower blood pressure. It can also help reduce swelling (inflammation) and have a drying (astringent) effect on the tissues.

PERIWINKLE Uses & Effectiveness What is this?

Insufficient Evidence for:

More evidence is needed to rate the effectiveness of periwinkle for these uses.

PERIWINKLE Side Effects & Safety

Periwinkle is UNSAFE. It can cause side effects such as nausea, vomiting, and other stomach and intestinal symptoms. It can also cause nerve, kidney, and liver damage. Large amounts can cause very low blood pressure.

Special Precautions & Warnings:

Periwinkle is UNSAFE for anyone to use, but people with certain conditions are especially at risk for harmful side effects.

Pregnancy and breast-feeding: Periwinkle is UNSAFE. Don’t use it.

Constipation: Periwinkle has a drying effect on tissues. This means it can make constipation worse. Don’t use it.

Low blood pressure: Periwinkle can lower blood pressure. If you already have low blood pressure, using periwinkle can make it drop too low. Don’t use it.

Surgery: Periwinkle can lower blood pressure. There is a concern that it might interfere with blood pressure control during and after surgery. Stop using periwinkle at least 2 weeks before a scheduled surgery.

PERIWINKLE Interactions What is this?

Moderate Interaction Be cautious with this combination

  • Medications for high blood pressure (Antihypertensive drugs) interacts with PERIWINKLE

    Periwinkle seems to decrease blood pressure. Taking periwinkle along with medications for high blood pressure might cause your blood pressure to go too low.
    Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.


The appropriate dose of periwinkle depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for periwinkle. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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