PEPPERMINT Overview Information
Peppermint is a plant. The leaf and oil are used as medicine.
Peppermint is used for the common cold, cough, inflammation of the mouth and throat, sinus infections, and respiratory infections. It is also used for digestive problems including heartburn, nausea, vomiting, morning sickness, irritable bowel syndrome (IBS), cramps of the upper gastrointestinal (GI) tract and bile ducts, upset stomach, diarrhea, bacterial overgrowth of the small intestine, and gas.
Some people also use peppermint for menstrual problems, liver and gallbladder complaints, preventing spasms during endoscopy procedures, and as a stimulant.
Peppermint oil is applied to the skin for headache, muscle pain, nerve pain, toothache, inflammation of the mouth, joint conditions, itchiness, allergic rash, bacterial and viral infections, relaxing the colon during barium enemas, and for repelling mosquitoes.
Some people inhale peppermint oil for treating symptoms of cough and colds, and as a painkiller.
In foods and beverages, peppermint is a common flavoring agent.
In manufacturing, peppermint oil is used as a fragrance in soaps and cosmetics, and as a flavoring agent in pharmaceuticals.
In 1990, the FDA banned the sale of peppermint oil as an over-the-counter drug for use as a digestive aid because its effectiveness had not been proven. Today, peppermint is sold as a dietary supplement. Unlike over-the-counter medications, dietary supplements do not have to be proven effective to the satisfaction of the FDA in order to be marketed. Also, unlike over-the-counter medications, dietary supplements are not allowed to claim that they prevent or treat illness.
How does it work?
Peppermint oil seems to reduce spasms in the digestive tract. When applied to the skin, it can cause surface warmth, which relieves pain beneath the skin.
PEPPERMINT Uses & Effectiveness 
Possibly Effective for:
- Heartburn (dyspepsia). Taking peppermint oil orally in combination with caraway oil seems to reduce feelings of fullness and mild gastrointestinal (GI) spasms. A specific combination product containing peppermint leaf (Iberogast, Medical Futures, Inc) also seems to improve symptoms of heartburn. The combination includes peppermint leaf plus clown’s mustard plant, German chamomile, caraway, licorice, milk thistle, angelica, celandine, and lemon balm. It seems to significantly reduce severity of acid reflux, stomach pain, cramping, nausea, and vomiting.
- Relaxing the colon during medical exams, including barium enemas or radiologic procedures, when taken by mouth or added to the barium solution.
- Irritable bowel syndrome (IBS). Most research shows that peppermint oil can improve symptoms of irritable bowel syndrome such as stomach pain and flatulence. But some other research has not found any benefit. The reason for the different findings is not clear.
- Tension headaches, when applied to the skin of the affected area.
Possibly Ineffective for:
- Nausea following surgery.
Insufficient Evidence for:
- Relieving pain due to viral disease called shingles, when peppermint oil is applied to the skin of the affected area.
- Toothaches.
- Itchy skin.
- Infections.
- Morning sickness.
- Nausea and vomiting.
- Painful menstrual periods.
- Bacteria overgrowth in the intestines.
- Lung infections.
- Spasms of the stomach and gallbladder.
- Spasms during endoscopy procedures.
- Cough and symptoms of cold.
- Inflammation of mouth and respiratory tract lining.
- Muscle or nerve pain.
- Other conditions.
PEPPERMINT Side Effects & Safety
Peppermint is LIKELY SAFE when taken by mouth in amounts commonly found in food. The oil is POSSIBLY SAFE when taken in medicinal amounts or when applied to the skin. The leaf is POSSIBLY SAFE when taken in amounts used for medicine short-term (up to 8 weeks). The safety of using peppermint leaf long-term is unknown.
Peppermint can cause some side effects including heartburn, and allergic reactions including flushing, headache, and mouth sores.
Peppermint oil, when taken by mouth in pills with a special (enteric) coating to prevent contact with the stomach, is LIKELY SAFE for children 8 years of age and older.
Special Precautions & Warnings:
Pregnancy and breast-feeding: It is LIKELY SAFE to take peppermint in amounts normally found in food during pregnancy and breast-feeding. But not enough is known about the safety of taking larger amounts used for medicine. It’s best not to take these larger amounts if you are pregnant or breast-feeding.A stomach condition in which the stomach is not producing hydrochloric acid (achlorhydria): Don’t use enteric-coated peppermint oil if you have this condition. The enteric coating might dissolve too early in the digestive process.
Diarrhea: Enteric-coated peppermint oil could cause anal burning, if you have diarrhea.
PEPPERMINT Interactions
Moderate Interaction Be cautious with this combination
- Cyclosporine (Neoral, Sandimmune) interacts with PEPPERMINT
The body breaks down cyclosporine (Neoral, Sandimmune) to get rid of it. Peppermint oil might decrease how quickly the body breaks down cyclosporine (Neoral, Sandimmune). Taking peppermint oil products along with cyclosporine (Neoral, Sandimmune) might increase the risk of side effects for cyclosporine (Neoral, Sandimmune).
- Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with PEPPERMINT
Some medications are changed and broken down by the liver
Peppermint oil and leaf might decrease how quickly the liver breaks down some medications. Taking peppermint oil along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking peppermint oil, talk to your healthcare provider if you take any medications that are changed by the liver
Some medications that are changed by the liver include amitriptyline (Elavil), haloperidol (Haldol), ondansetron (Zofran), propranolol (Inderal), theophylline (Theo-Dur, others), verapamil (Calan, Isoptin, others), and others. - Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates) interacts with PEPPERMINT
Some medications are changed and broken down by the liver
Peppermint oil might decrease how quickly the liver breaks down some medications. Taking peppermint oil along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking peppermint oil, talk to your healthcare provider if you take any medications that are changed by the liver
Some medications that are changed by the liver include omeprazole (Prilosec), lansoprazole (Prevacid), and pantoprazole (Protonix); diazepam (Valium); carisoprodol (Soma); nelfinavir (Viracept); and others. - Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with PEPPERMINT
Some medications are changed and broken down by the liver.
Peppermint oil might decrease how quickly the liver breaks down some medications. Taking peppermint oil along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking peppermint oil, talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications that are changed by the liver include diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), and piroxicam (Feldene); celecoxib (Celebrex); amitriptyline (Elavil); warfarin (Coumadin); glipizide (Glucotrol); losartan (Cozaar); and others. - Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with PEPPERMINT
Some medications are changed and broken down by the liver.
Peppermint oil might decrease how quickly the liver breaks down some medications. Taking peppermint oil along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking peppermint oil, talk to your healthcare provider if you are taking any medications that are changed by the liver
Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.
Minor Interaction Be watchful with this combination
- Antacids interacts with PEPPERMINT
Some peppermint oil products are covered with a special coating. Antacids are used to decrease stomach acid. Low stomach acid can cause the coating of these peppermint oil products to dissolve too quickly. When peppermint oil products dissolve too quickly they can sometimes cause heartburn and nausea. Take antacids at least two hours after coated peppermint oil products.
Some antacids include calcium carbonate (Tums, others), dihydroxyaluminum sodium carbonate (Rolaids, others), magaldrate (Riopan), magnesium sulfate (Bilagog), aluminum hydroxide (Amphojel), and others. - Medications that decrease stomach acid (H2-Blockers) interacts with PEPPERMINT
Some peppermint oil products are covered with a special coating. Some medications that decrease stomach acid might cause the coating of these peppermint oil products to dissolve too quickly. When peppermint oil products dissolve too quickly they can sometimes cause heartburn and nausea. Take medications that decrease stomach acid at least two hours after coated peppermint oil products
Some medications that decrease stomach acid include cimetidine (Tagamet), ranitidine (Zantac), nizatidine (Axid), and famotidine (Pepcid). - Medications that decrease stomach acid (Proton pump inhibitors) interacts with PEPPERMINT
Some peppermint oil products are covered with a special coating. Some medications that decrease stomach acid might cause the coating of these peppermint oil products to dissolve too quickly. When peppermint oil products dissolve too quickly they can sometimes cause heartburn and nausea. Take medications that decrease stomach acid at least two hours after coated peppermint oil products
Some medications that decrease stomach acid include omeprazole (Prilosec), lansoprazole (Prevacid), rabeprazole (Aciphex), pantoprazole (Protonix), and esomeprazole (Nexium).
PEPPERMINT Dosing
The following doses have been studied in scientific research:
BY MOUTH:
- For upset stomach: Peppermint oil 90 mg per day has been used in combination with caraway oil. A specific combination product containing peppermint leaf and several other herbs (Iberogast, Medical Futures, Inc) has been used in a dose of 1 mL three times daily.
- For tension headaches: 10% peppermint oil in ethanol solution applied across the forehead and temples, repeated after 15 and 30 minutes, has been used.
- For decreasing colonic spasms during barium enema: 8 mL of peppermint oil was added to 100 mL water along with a surface active agent, Tween 80. The insoluble fraction was removed, then 30 mL of the remaining peppermint solution was added to 300 mL of the barium solution.
