Medically Reviewed by Zilpah Sheikh, MD on August 28, 2023
Different Diseases, Similar Symptoms

Different Diseases, Similar Symptoms


There are more than 100 different liver diseases. They have different causes, including:

  • Infection
  • Too much alcohol
  • Medications, illegal drugs, or toxins
  • Obesity
  • Cancer

Even though there are different diseases and different causes, many liver conditions damage the liver in similar ways. Because of this, they can look similar and cause similar symptoms.

Acute vs. Chronic

Acute vs. Chronic


Sometimes liver damage or even liver failure and related symptoms will be acute, or come on quickly. This can happen if you take too much acetaminophen or other medicines. Herbal supplements, viruses, and autoimmune conditions also can cause this. But most of the time, liver diseases and liver failure are chronic. This means they happen gradually as the liver is damaged slowly over time. In this case, symptoms can come on more gradually too.

Early Liver Disease Symptoms

Early Liver Disease Symptoms


You might not notice early symptoms. If you do, it might be hard to know what’s causing them. That’s because early signs of liver trouble are vague, like:

  • Belly pain
  • Not feeling hungry
  • Tiredness or lack of energy
  • Diarrhea

You may just feel generally sick or unwell and not know why.

Yellow Skin or Eyes (Jaundice)

Yellow Skin or Eyes (Jaundice)


As the liver gets more damaged, you may notice clearer signs of a problem. Your skin may look yellow along with the whites of your eyes. Doctors call this jaundice. This happens when too much of a yellow substance from your red blood cells called bilirubin builds up. Normally, your liver would clear the bilirubin out. But a damaged liver can’t keep up, so levels rise.

Itchy Skin

Itchy Skin


If you have lasting liver problems, you may feel itchy. This happens even though you don’t have a rash or anything on your skin. The itchiness can make it hard to do things like sleep. It keeps up even if you scratch. If you have this, ask your doctor if there’s medicine that can help.

Swollen Belly (Ascites)

Swollen Belly (Ascites)


If your liver is scarred, it can block blood flow to your liver and raise the pressure in blood vessels around it. This makes fluid seep out and collect in your belly. There may be a little fluid and swelling or a lot. Your belly may get very large and your belly button might push out. Sometimes ascites gets infected and needs antibiotics. If there’s a lot of extra fluid with nowhere to go, you may need to have it drained with a tube.

Swollen Legs or Ankles

Swollen Legs or Ankles


In some people with ascites, legs and ankles also swell as fluid builds up. It might help to eat less salt or take medicine that makes you pee more.

Pale Poop and Dark Pee

Pale Poop and Dark Pee


Your liver is the reason that healthy poop looks brown. The brown color comes from bile salts made by your liver. If your liver doesn’t make bile normally or if the flow from the liver is blocked, your poop will look pale like the color of clay. Pale poop often happens along with yellow skin (jaundice). The extra bilirubin that makes your skin look yellow also can make your pee unusually dark.

Fatigue and Confusion

Fatigue and Confusion


Many people with liver disease suffer from lingering fatigue. This might happen because of toxins building up since your liver isn’t clearing them like it should. The buildup of toxins in your body and bloodstream also can affect brain function. You might get confused or find it hard to concentrate. You might forget things or notice other changes as liver disease affects your brain.

Nausea and Vomiting

Nausea and Vomiting


Your stomach might get upset early on if you have liver disease. As the disease and damage to your liver go on, raised toxin levels can make this worse. Lingering nausea or throwing up often are a sign of liver problems. If your liver is failing, you also may have blood in your vomit or poop.

Bruising Easily or Bleeding

Bruising Easily or Bleeding


If your liver is failing, you may notice you get bruises more easily. If you get a cut or nosebleed, it may not stop like it should. While people with advanced liver disease are prone to bleeding, they also are more likely to get blood clots.

Red Palms and ‘Spider Webs’

Red Palms and ‘Spider Webs’


You may have red marks from blood vessels under your skin that look like spider webs. Doctors call these spider naevi. They often happen on the cheeks, nose, and neck. One study in people who were alcoholics found that these are a strong indicator of liver problems. People with these spider-like marks also often have reddened palms (palmar erythema). Blotchy red palms are another symptom of advanced liver disease.

Catching Liver Disease Sooner

Catching Liver Disease Sooner


It’s possible you could have liver disease without knowing it. Lots of people with liver problems don’t seem sick. As damage to the liver gets worse, symptoms will start. If the damage has gone too far, there might not be any way to fix it. But knowing what to look for could help to catch liver problems early. That way you’ll have a chance to stop more damage and let your liver heal before it’s too late.

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American Liver Foundation: “The Progression of Liver Disease.”

Mayo Clinic: "Acute Liver Failure,” “Liver disease,” “Cirrhosis.”

National Health Service, U.K.: “Alcohol-Related Liver Disease,” “Cirrhosis.”

Scientific Reports: “Pruritus is common in patients with chronic liver disease and is improved by nalfurafine hydrochloride.”

Mount Sinai: “Stools - pale or clay-colored.”

Hopkins Medicine: “Common Characteristics of Liver Disease.”

Canadian Journal of Gastroenterology: “Fatigue in liver disease: Pathophysiology and clinical management.”

Hawaii Pacific Health: "Love Your Liver: Look for These 8 Signs of Organ Damage.”

Merck Manual: “Liver Failure.”

Journal of Translational Science: “Hemostasis, bleeding and thrombosis in liver disease.”

The Australasian College of Dermatologists: “Spider Naevi.”

Galicia Clinica: “Diagnostic accuracy of spider naevi for liver disease detection in alcoholics.”

Case Reports in Dermatology: “Erythema Palmare Hereditarium (‘Red Palms’, ‘Lane's Disease’).”

Patient: “Palmar Erythema.”

American Journal of Clinical Dermatology: “Palmar erythema.”