Does XALKORI Interact with other Medications?

Severe Interactions

These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • STRONG AND MODERATE CYP3A4 INHIBITORS/LONAFARNIB
  • STRONG & MOD 3A4 INHIB THAT PROLONG QT/CILOSTAZOL (> 50 MG)
  • SELECTED CYP3A4 MODERATE INHIBITORS/LURASIDONE (> 80 MG)
  • STRONG AND MODERATE CYP3A4 INHIBITORS/ASUNAPREVIR
  • STRONG OR MODERATE CYP3A4 INHIBITORS/LOMITAPIDE
  • SELECTED IMMUNOSUPPRESSANTS/TALIMOGENE LAHERPAREPVEC
  • MODERATE CYP3A4 INHIBITORS/NALOXEGOL (> 12.5 MG)
  • MODERATE CYP3A4 INHIBITORS/RANOLAZINE (> 500 MG BID)
  • MODERATE CYP3A4 INHIBITORS/AVANAFIL (> 50 MG)
  • STRONG OR MODERATE CYP3A4 INHIBITORS/FLIBANSERIN
  • SELECTED IMMUNOSUPPRESSIVE AGENTS/LIVE VACCINES; LIVE BCG
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/EFALIZUMAB; NATALIZUMAB
  • Serious Interactions

    These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • SLT ANTINEOPLASTIC SYSTEMIC ENZYME INHIB/ST. JOHN'S WORT
  • SLT ANTINEOPLASTIC SYSTEMIC ENZYME INHIB/STRONG 3A4 INDUCERS
  • SLT ANTINEO SYSTEMIC ENZYME INHIBITORS/FLUCONAZOLE
  • CRIZOTINIB/QT PROLONGING AGENTS
  • SELECTED ANTINEOPLASTICS THAT PROLONG QT/SAQUINAVIR
  • CRIZOTINIB/AGENTS THAT CAUSE BRADYCARDIA
  • CRIZOTINIB/STRONG CYP3A4 INHIBITORS
  • CRIZOTINIB/STRONG CYP3A4 INHIBITORS THAT PROLONG QT
  • CRIZOTINIB/SELECTED MODERATE CYP3A4 INDUCERS
  • CRIZOTINIB/BOSENTAN
  • CRIZOTINIB/MODERATE CYP3A4 INDUCERS THAT PROLONG QT
  • CRIZOTINIB/PEXIDARTINIB
  • ANTINEOPLASTIC SYST ENZYME INH THAT INHIBIT 3A4/CARBAMAZEPIN
  • ANTINEOPLASTIC SYST ENZYME INHIB THAT PROLONG QT/APALUTAMIDE
  • SLT ANTINEOPLASTIC SYSTEMIC ENZYME INH/LUMACAFTOR-IVACAFTOR
  • CRIZOTINIB/MAVACAMTEN
  • MODERATE CYP3A4 INHIBITORS THAT PROLONG QT/PACRITINIB
  • CRIZOTINIB/MITAPIVAT
  • STRONG & MODERATE 3A4 INHIB THAT PROLONG QT/ENCORAFENIB
  • MODERATE 3A4 INHIBITORS THAT PROLONG QT/MOBOCERTINIB
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/CLADRIBINE
  • IMMUNOSUPPRESSIV; IMMUNOMODULATORS THAT PROLONG QT/SIPONIMOD
  • IMMUNOSUPPRESSIVES;IMMUNOMODULATORS THAT PROLONG QT/OZANIMOD
  • IMMUNOSUPPRES;IMMUNOMODULATORS THAT PROLONG QT/FINGOLIMOD
  • IMMUNOSUPPRESSIV;IMMUNOMODULATORS THAT PROLONG QT/PONESIMOD
  • STRONG & MODERATE 3A4 INHIBITOR THAT PROLONG QT/FEXINIDAZOLE
  • MYELOSUPPRESSIVES; IMMUNOMODULATORS/SODIUM IODIDE I 131
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/FILGOTINIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/INFIGRATINIB
  • SELECTED MODERATE CYP3A4 INHIBITORS/ALPRAZOLAM
  • SELECTED IMMUNOSUPPRESSANTS/LEFLUNOMIDE
  • MODERATE CYP3A4 INHIBITORS/VOCLOSPORIN
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/BARICITINIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/LURBINECTEDIN
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/INEBILIZUMAB
  • MODERATE CYP3A4 INHIBITORS THAT PROLONG QT/SELPERCATINIB
  • MODERATE CYP3A4 INHIBITORS THAT PROLONG QT/IVABRADINE
  • STRONG AND MODERATE CYP3A4 INHIBITORS/PEMIGATINIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/SELUMETINIB
  • MYELOSUPPRESSIVE AGENTS THAT PROLONG QT/CLOZAPINE
  • STRONG AND MODERATE CYP3A4 INHIBITORS/LUMATEPERONE
  • STRONG AND MODERATE CYP3A4 INHIBITORS/LEMBOREXANT
  • CRIZOTINIB/SELECTED CYP3A4 SUBSTRATES
  • POSSIBLE QT PROLONGING AGENTS/HYDROXYCHLOROQUINE
  • MODERATE CYP3A4 INHIBITORS/ELEXACAFTOR-TEZACAFTOR-IVACAFTOR
  • STRONG & MOD CYP3A4 INHIBITOR THAT PROLONG QT/ORAL LEFAMULIN
  • MODERATE CYP3A4 INHIBITORS THAT PROLONG QT/ENTRECTINIB
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/UPADACITINIB
  • MODERATE CYP3A4 INHIBITORS/BRIGATINIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/TEZACAFTOR-IVACAFTOR
  • CERITINIB; CRIZOTINIB/SELECTED OPIOIDS
  • STRONG AND MODERATE CYP3A4 INHIBITORS/DEFLAZACORT
  • IMMUNOSUPPRES;IMMUNOMODUL/SELECTED MULTIPLE SCLEROSIS AGENTS
  • MODERATE CYP3A4 INHIBITORS/NALOXEGOL (<= 12.5 MG)
  • MODERATE CYP3A4 INHIBITORS/COBIMETINIB; OLAPARIB; SONIDEGIB
  • STRONG & MODERATE CYP3A4 INHIBITORS/ELIGLUSTAT
  • MODERATE CYP3A4 INHIBITORS/SUVOREXANT (> 10 MG)
  • MODERATE CYP3A4 INHIBITORS/ERGOT ALKALOIDS
  • POSSIBLE QT PROLONGING AGENTS/ANAGRELIDE
  • STRONG & MODERATE CYP3A4 INHIBITORS/GUANFACINE
  • STRONG OR MODERATE CYP3A4 INHIBITORS/SIMEPREVIR
  • MODERATE CYP3A4 INHIBITORS/BOSUTINIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/IVACAFTOR
  • SELECTED MYELOSUPPRESSIVE AGENTS/DEFERIPRONE
  • MODERATE CYP3A4 INHIBITORS/COLCHICINE
  • POSSIBLE QT PROLONGING AGENTS/DRONEDARONE
  • MODERATE CYP3A4 INHIBITORS/TOLVAPTAN
  • POSSIBLE QT PROLONGING AGENTS/ARTEMETHER-LUMEFANTRINE
  • POSSIBLE QT PROLONGING AGENTS/DISOPYRAMIDE
  • SELECTED QT PROLONGING AGENTS/ZIPRASIDONE
  • POSSIBLE QT PROLONGING AGENTS/SERTINDOLE
  • POSSIBLE QT PROLONGING AGENTS/DROPERIDOL
  • POSSIBLE QT PROLONGING AGENTS/LEVOMETHADYL
  • POSSIBLE QT PROLONGING AGENTS/SPARFLOXACIN
  • POSSIBLE QT PROLONGING AGENTS/HALOFANTRINE
  • POSSIBLE QT PROLONGING AGENTS/BEPRIDIL
  • SELECTED MODERATE CYP3A4 INHIBITORS/EPLERENONE
  • Moderate Interactions

    These medications may cause some risk when taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • CRIZOTINIB/POSSIBLE QT PROLONGING AGENTS
  • MYELOSUPPRESSIVE OCT2 SUBSTRATES THAT PROLONG QT/TRILACICLIB
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/SARILUMAB; TOCILIZUMAB
  • QT PROLONGING AGENTS/TRICLABENDAZOLE
  • MODERATE CYP3A4 INHIBITORS/DARIDOREXANT
  • QT PROLONGING AGENTS/TOLTERODINE
  • SELECTED POSSIBLE QT PROLONGING AGENTS/INTRAVENOUS LEFAMULIN
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/COVID-19 VACCINES
  • CRIZOTINIB/IVOSIDENIB
  • QT PROLONGING AGENTS/GALANTAMINE
  • POSSIBLE QT PROLONGING AGENTS/LEVOMEPROMAZINE
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/USTEKINUMAB
  • QT PROLONGING AGENTS/SUNITINIB
  • MODERATE CYP3A4 INHIBITORS THAT PROLONG QT/QUETIAPINE
  • POSSIBLE QT PROLONGING AGENTS/OXALIPLATIN
  • QT PROLONGING AGENTS/OSILODROSTAT
  • QT PROLONGING AGENTS/AMISULPRIDE
  • MODERATE CYP3A4 INHIBITORS/RIMEGEPANT
  • MODERATE CYP3A4 INHIBITORS/TAZEMETOSTAT
  • MODERATE CYP3A4 INHIBITORS/AVAPRITINIB
  • MODERATE CYP3A4 INHIBITORS/UBROGEPANT
  • MODERATE CYP3A4 INHIBITORS/ZANUBRUTINIB
  • SELECTED CYP3A4 MODERATE INHIBITORS/LURASIDONE (<= 80 MG)
  • QT PROLONGING AGENTS/PITOLISANT
  • QT PROLONGING AGENTS/GILTERITINIB
  • POSSIBLE QT PROLONGING AGENTS/GLASDEGIB
  • POSSIBLE QT PROLONGING AGENTS/TRAZODONE (< 100 MG)
  • POSSIBLE QT PROLONGING AGENTS/LOFEXIDINE
  • MODERATE CYP3A4 INHIBITORS/CABERGOLINE
  • POSSIBLE QT PROLONGING AGENTS/MACIMORELIN
  • SELECTED MODERATE CYP3A4 INHIBITORS/ACALABRUTINIB
  • POSSIBLE QT PROLONGING AGENTS/INOTUZUMAB OZOGAMICIN
  • MODERATE CYP3A4 INHIBITORS/BROMOCRIPTINE
  • POSSIBLE QT PROLONGING AGENTS/HYDROXYZINE
  • POSSIBLE QT PROLONGING AGENTS/PIMAVANSERIN
  • POSSIBLE QT PROLONGING AGENTS/OSIMERTINIB
  • MODERATE CYP3A4 INHIBITORS/BREXPIPRAZOLE
  • POSSIBLE QT PROLONGING AGENTS/LENVATINIB
  • POSSIBLE QT PROLONGING AGENTS/DELAMANID
  • MODERATE CYP3A4 INHIBITORS/SUVOREXANT (<= 10 MG)
  • POSSIBLE QT PROLONGING AGENTS/TRAZODONE (>= 100 MG)
  • MODERATE CYP3A4 INHIBITORS/AVANAFIL (<= 50 MG)
  • MODERATE CYP3A4 INHIBITORS/IBRUTINIB
  • POSSIBLE QT PROLONGING AGENTS/BEDAQUILINE
  • QT PROLONGING AGENTS/PASIREOTIDE
  • POSSIBLE QT PROLONGING AGENTS/SORAFENIB
  • POSSIBLE QT PROLONGING AGENTS/GADOFOSVESET
  • POSSIBLE QT PROLONGING AGENTS/ILOPERIDONE
  • POSSIBLE QT PROLONGING AGENTS/TOREMIFENE
  • MODERATE CYP3A4; P-GP INHIBITORS/EVEROLIMUS
  • POSSIBLE QT PROLONGING AGENTS/ZUCLOPENTHIXOL
  • POSSIBLE QT PROLONGING AGENTS/NILOTINIB
  • POSSIBLE QT PROLONGING AGENTS/PALIPERIDONE
  • MODERATE CYP3A4 INHIBITORS/RANOLAZINE (<=500 MG BID)
  • POSSIBLE QT PROLONGING AGENTS/AMIODARONE
  • STRONG & MOD 3A4 INHIB THAT PROLONG QT/CILOSTAZOL (<=50MG)
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    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.