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    Elviteg-Cobi-Emtric-Tenofov DF Tablet

    Interactions

    Itraconazole; Ketoconazole/Selected 3A4 Inhibitors

    This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

    Medical warning:

    Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

    How the interaction occurs:

    Some medicines may slow down how quickly your liver processes itraconazole and ketoconazole. Itraconazole and ketoconazole may slow down how quickly your liver processes ritonavir and may speed up how quickly your liver processes lopinavir.

    What might happen:

    The amount of itraconazole and ketoconazole in your blood may increase and cause side effects. You may notice more side effects from your ritonavir as well.

    What you should do about this interaction:

    Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to decrease the dose of itraconazole and ketoconazole. Let your doctor know if you have nausea, yellowing of the eyes or skin, unusual weakness, dark urine, pale stools, numbness or tingling of the hands or feet, depression, trouble breathing, or swelling of the ankles or feet.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

    References:

    1.Stribild (elvitegravir, cobicistat, emtricitabine, tenofovir) prescribing information. Gilead Sciences, Inc. August, 2017.

    2.Prezista (darunavir) US prescribing information. Tibotec Inc. June 19, 2017.

    3.Lexiva (fosamprenavir calcium) US prescribing information. GlaxoSmithKline September, 2016.

    4.Kaletra (lopinavir/ritonavir tablets) US prescribing information. Abbott Laboratories June 15, 2017.

    5.Aptivus (tipranavir) US prescribing information. Boehringer Ingelheim Pharmaceuticals, Inc. September, 2016.

    6.Norvir (ritonavir) US prescribing information. Abbott Laboratories June 29, 2017.

    7.Invirase (saquinavir mesylate) US prescribing information. Roche Laboratories, Inc. September, 2016.

    8.Nizoral (ketoconazole oral) US prescribing information. Janssen Pharmaceuticals February, 2014.

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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