Does Zydelig Interact with other Medications?

Severe Interactions

These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • SELECTED CYP3A4 INHIBITORS/PIMOZIDE
  • STRONG CYP3A4 INHIBITORS/PIMAVANSERIN (> 10 MG)
  • STRONG CYP3A4 INHIBITORS/MAVACAMTEN
  • STRONG CYP3A4 INHIBITORS/PACRITINIB
  • SELECTED STRONG CYP3A4 INHIBITORS/CONIVAPTAN
  • SELECTED STRONG CYP3A4 INHIBITORS/ALFUZOSIN
  • STRONG CYP3A4 INHIBITORS/FINERENONE
  • STRONG CYP3A4 INHIBITORS/VOCLOSPORIN
  • STRONG AND MODERATE CYP3A4 INHIBITORS/LONAFARNIB
  • STRONG CYP3A4 INHIBITORS/LUMATEPERONE (>10.5 MG)
  • STRONG CYP3A4 INHIBITORS/UBROGEPANT
  • SELECTED STRONG CYP3A4 INHIBITORS/ALPRAZOLAM; TRIAZOLAM
  • STRONG CYP3A4 INHIBITORS; ATAZANAVIR;DARUNAVIR/LERCANIDIPINE
  • SLT STRONG & MODERATE CYP3A4 INHIBITORS/CILOSTAZOL (>50MG)
  • STRONG CYP3A4 INHIBITORS/DAPAGLIFLOZIN-SAXAGLIPTIN-METFORMIN
  • STRONG AND MODERATE CYP3A4 INHIBITORS/ASUNAPREVIR
  • STRONG OR MODERATE CYP3A4 INHIBITORS/LOMITAPIDE
  • SELECTED IMMUNOSUPPRESSANTS/TALIMOGENE LAHERPAREPVEC
  • SELECTED STRONG CYP3A4 INHIBITORS/ISAVUCONAZONIUM
  • STRONG CYP3A4 INHIBITORS/PANOBINOSTAT (> 10 MG)
  • STRONG CYP3A4 INHIBITORS/AVANAFIL
  • 3A4INHIB/DAPOXETINE;LEVOMILNACIPRAN(>80MG);VILAZODONE(>20MG)
  • STRONG OR MODERATE CYP3A4 INHIBITORS/FLIBANSERIN
  • SELECTED STRONG CYP3A4 INHIBITORS/ERGOT ALKALOIDS
  • STRONG CYP3A4 INHIBITORS/SLT HIGH STRENGTH ANTIMUSCARINICS
  • SELECTED STRONG CYP3A4 INHIBITORS/DOMPERIDONE; CISAPRIDE
  • SELECTED CYP3A4 INHIBITORS/ORAL MIDAZOLAM
  • STRONG CYP3A4 INHIBITORS; PROTEASE INHIBITORS/TICAGRELOR
  • SELECTED STRONG CYP3A4 INHIBITORS/LURASIDONE
  • STRONG CYP3A4 INHIB;ATAZANAV;DARUNAVIR/SAXAGLIPTIN (>2.5 MG)
  • STRONG CYP3A4 INHIBITORS; ATAZANAVIR; DARUNAVIR/DRONEDARONE
  • SELECTED IMMUNOSUPPRESSIVE AGENTS/LIVE VACCINES; LIVE BCG
  • STRONG CYP3A4 INHIBITORS; PROTEASE INHIBITORS/RANOLAZINE
  • STRONG CYP3A4 INHIBITORS/TOLVAPTAN
  • STRONG CYP3A4 INHIBITORS; PROTEASE INHIBITORS/IVABRADINE
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/EFALIZUMAB; NATALIZUMAB
  • STRONG CYP3A4 INHIBITORS/SILODOSIN; TAMSULOSIN
  • STRONG CYP3A4 INHIBITORS/EPLERENONE
  • STRONG CYP3A4 INHIBITORS/IRINOTECAN
  • SELECTED CYP3A4 INHIBITORS/LOVASTATIN; SIMVASTATIN
  • STRONG CYP3A4 INHIBITORS/VARDENAFIL (>2.5 MG)
  • Serious Interactions

    These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • SLT ANTINEOPLASTIC SYSTEMIC ENZYME INHIB/ST. JOHN'S WORT
  • SLT ANTINEOPLASTIC SYSTEMIC ENZYME INHIB/STRONG 3A4 INDUCERS
  • IDELALISIB/STRONG CYP3A4 INHIBITORS
  • IDELALISIB/MODERATE CYP3A4 INDUCERS
  • ANTINEOPLASTIC SYST ENZYME INH THAT INHIBIT 3A4/CARBAMAZEPIN
  • ANTINEOPLASTIC SYSTEMIC ENZYME INHIBITORS/APALUTAMIDE
  • SELECTED STRONG CYP3A4 INHIBITORS/TACROLIMUS
  • IDELALISIB/MITAPIVAT
  • STRONG CYP3A4 INHIBITOR/TOLTERODINE (>1 MG IR OR >2 MG ER)
  • STRONG CYP3A4 INHIBITORS/RIVOCERANIB
  • STRONG CYP3A4 INHIBITORS/DARIDOREXANT
  • IDELALISIB/LEVOKETOCONAZOLE
  • STRONG CYP3A4 INHIBITORS/UPADACITINIB (>=30 MG)
  • STRONG CYP3A4 INHIBITORS/RUPATADINE
  • STRONG CYP3A4 INHIBITORS/SURUFATINIB
  • STRONG CYP3A4 INHIBITORS/AVACOPAN
  • STRONG CYP3A4 INHIBITORS/MOBOCERTINIB
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/CLADRIBINE
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/SIPONIMOD
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/OZANIMOD
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/FINGOLIMOD
  • STRONG AND MODERATE CYP3A4 INHIBITORS/FEXINIDAZOLE
  • MYELOSUPPRESSIVES; IMMUNOMODULATORS/SODIUM IODIDE I 131
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/FILGOTINIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/INFIGRATINIB
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/PONESIMOD
  • SELECTED IMMUNOSUPPRESSANTS/LEFLUNOMIDE
  • IDELALISIB/PEXIDARTINIB
  • IDELALISIB/LORLATINIB
  • IDELALISIB/ELAGOLIX
  • IDELALISIB/RIBOCICLIB
  • IDELALISIB/MIFEPRISTONE
  • IDELALISIB/CERITINIB
  • IDELALISIB/BOSENTAN
  • STRONG CYP3A4 INHIBITORS/TOREMIFENE
  • STRONG CYP3A4 INHIBITORS/SUNITINIB
  • STRONG CYP3A4 INHIBITORS/PAZOPANIB
  • STRONG CYP3A4 INHIBITORS/NILOTINIB
  • STRONG CYP3A4 INHIBITORS/LAPATINIB
  • STRONG CYP3A4 INHIBITORS/DASATINIB
  • STRONG CYP3A4 INHIBITORS/CRIZOTINIB
  • IDELALISIB/DABRAFENIB
  • STRONG CYP3A4 INHIBITORS/VINFLUNINE
  • STRONG CYP3A4 INHIBITORS/VINCRISTINE
  • STRONG CYP3A4 INHIBITORS/VINBLASTINE
  • STRONG CYP3A4 INHIBITORS/TOFACITINIB
  • STRONG CYP3A4 INHIBITORS/SONIDEGIB
  • STRONG CYP3A4 INHIBITORS/RUXOLITINIB
  • STRONG CYP3A4 INHIBITORS/PONATINIB
  • STRONG CYP3A4 INHIBITORS/PALBOCICLIB
  • STRONG CYP3A4 INHIBITORS/PACLITAXEL
  • STRONG CYP3A4 INHIBITORS/OLAPARIB
  • STRONG CYP3A4 INHIBITORS/IXABEPILONE
  • STRONG CYP3A4 INHIBITORS/ERLOTINIB
  • STRONG CYP3A4 INHIBITORS/DOXORUBICIN
  • STRONG CYP3A4 INHIBITORS/DOCETAXEL
  • STRONG CYP3A4 INHIBITORS/COBIMETINIB
  • STRONG CYP3A4 INHIBITORS/CABOZANTINIB
  • STRONG CYP3A4 INHIBITORS/CABAZITAXEL
  • STRONG CYP3A4 INHIBITORS/AXITINIB
  • STRONG CYP3A4 INHIBITORS/SUVOREXANT
  • STRONG CYP3A4 INHIBITORS/PRALSETINIB
  • STRONG CYP3A4 INHIBITORS/PLITIDEPSIN
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/BARICITINIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/LURBINECTEDIN
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/INEBILIZUMAB
  • STRONG CYP3A4 INHIBITORS/SELPERCATINIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/PEMIGATINIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/SELUMETINIB
  • STRONG CYP3A4 INHIBITORS/RIMEGEPANT
  • STRONG CYP3A4 INHIBITORS/NIMODIPINE
  • STRONG CYP3A4 INHIBITORS/TAZEMETOSTAT
  • STRONG CYP3A4 INHIBITORS/AVAPRITINIB
  • SELECTED CYP3A4 INHIBITORS/FLUTICASONE-SALMETEROL
  • STRONG AND MODERATE CYP3A4 INHIBITORS/LEMBOREXANT
  • STRONG CYP3A4 INHIBITORS/ELEXACAFTOR-TEZACAFTOR-IVACAFTOR
  • STRONG CYP3A4 INHIBITORS/NALDEMEDINE
  • STRONG CYP3A4 INHIBITORS/ISTRADEFYLLINE
  • SELECTED STRONG CYP3A4 INHIBITORS/ORAL LEFAMULIN
  • STRONG CYP3A4 INHIBITORS/FEDRATINIB
  • STRONG CYP3A4 INHIBITORS/ENTRECTINIB
  • STRONG CYP3A4 INHIBITORS/BOSUTINIB
  • SELECTED STRONG CYP3A4 INHIBITORS/CLOPIDOGREL
  • STRONG CYP3A4 INHIBITORS/LAROTRECTINIB
  • STRONG CYP3A4 INHIBITORS/GLASDEGIB
  • STRONG CYP3A4 INHIBITORS/DUVELISIB
  • SELECTED STRONG CYP3A4 INHIBITORS/IVOSIDENIB
  • STRONG CYP3A4 INHIBITORS/ARIPIPRAZOLE LAUROXIL SUBMICRONIZED
  • STRONG AND MODERATE CYP3A4 INHIBITORS/ENCORAFENIB
  • IDELALISIB/SELECTED IMMUNOSUPPRESSANTS
  • STRONG AND MODERATE CYP3A4 INHIBITORS/TEZACAFTOR-IVACAFTOR
  • SELECTED STRONG CYP3A4 INHIBITOR;PROTEASE INHIB/DISOPYRAMIDE
  • STRONG CYP3A4 INHIBITORS/IBRUTINIB
  • STRONG CYP3A4 INHIBITORS/ACALABRUTINIB
  • STRONG CYP3A4 INHIBITORS/ABEMACICLIB
  • STRONG CYP3A4 INHIBITORS/COPANLISIB
  • STRONG CYP3A4 INHIB;MODERATE 3A4 & P-GP DUAL INHIB/NERATINIB
  • STRONG CYP3A4 INHIBITORS/BRIGATINIB
  • STRONG CYP3A4 INHIBITORS/VALBENAZINE
  • STRONG AND MODERATE CYP3A4 INHIBITORS/DEFLAZACORT
  • SLT STRONG 3A4 INHIBITORS/SILDENAFIL(PAH);TADALAFIL(BPH,PAH)
  • STRONG CYP3A4 INHIBITORS/VENETOCLAX
  • STRONG CYP3A4 INHIBITORS/VEMURAFENIB
  • STRONG CYP3A4 INHIBITORS/TRABECTEDIN
  • STRONG CYP3A4 INHIBITORS/CARIPRAZINE
  • IMMUNOSUPPRES;IMMUNOMODUL/SELECTED MULTIPLE SCLEROSIS AGENTS
  • STRONG CYP3A4 INHIB;ATAZANAV;DARUNAVIR/BEDAQUILINE;DELAMANID
  • SLT STRONG CYP3A4 INHIBITOR & SUBSTRATE/LUMACAFTOR-IVACAFTOR
  • STRONG CYP3A4 INHIBITORS/TRASTUZUMAB EMTANSINE
  • STRONG 3A4 INHIBITORS/ESZOPICLONE > 2 MG; ZOPICLONE > 5 MG
  • STRONG CYP3A4 INHIBITORS/VORAPAXAR
  • STRONG & MODERATE CYP3A4 INHIBITORS/GUANFACINE
  • STRONG OR MODERATE CYP3A4 INHIBITORS/SIMEPREVIR
  • STRONG CYP3A4 INHIBITORS/MACITENTAN
  • STRONG CYP3A4 INHIBITORS/QUETIAPINE
  • SELECTED MYELOSUPPRESSIVE AGENTS/CLOZAPINE
  • STRONG CYP3A4 INHIBITORS/REGORAFENIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/IVACAFTOR
  • SELECTED MYELOSUPPRESSIVE AGENTS/DEFERIPRONE
  • STRONG CYP3A4 INHIBITORS/EVEROLIMUS
  • STRONG CYP3A4 INHIBITORS/MARAVIROC
  • STRONG CYP3A4 INHIBITORS; ATAZANAVIR/COLCHICINE
  • SELECTED CYP3A4 INHIBITORS/SELECTED OPIOIDS
  • SELECTED CYP3A4 INHIBITORS/TRAZODONE
  • SELECTED CYP3A4 INHIBITORS/SELECTED STEROIDS
  • Moderate Interactions

    These medications may cause some risk when taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • STRONG CYP3A4 INHIBITORS/LUMATEPERONE (<=10.5 MG)
  • SELECTED CYP3A4 INHIBITORS/MOMETASONE
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/SARILUMAB; TOCILIZUMAB
  • STRONG CYP3A4 INHIBITORS/GILTERITINIB
  • STRONG CYP3A4 INHIBITORS/TOLTERODINE (<=1 MG OR <=2 MG ER)
  • STRONG CYP3A4 INHIBITORS/UPADACITINIB (<30 MG)
  • STRONG CYP3A4 INHIBITORS/ATOGEPANT
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/COVID-19 VACCINES
  • STRONG CYP3A4 INHIBITORS/IBREXAFUNGERP
  • STRONG CYP3A4 INHIBITORS/REPAGLINIDE
  • IMMUNOSUPPRESSIVES; IMMUNOMODULATORS/USTEKINUMAB
  • STRONG CYP2D6 OR CYP3A4 INHIBITORS/OLICERIDINE
  • STRONG CYP3A4 INHIBITORS/FOSTAMATINIB
  • STRONG CYP3A4 INHIBITORS/OSILODROSTAT
  • SELECTED STRONG CYP3A4 INHIBITORS/ROMIDEPSIN
  • STRONG CYP3A4 INHIBITORS/CANNABIDIOL-TETRAHYDROCANNABINOL
  • SELECTED STRONG CYP3A4 INHIBITORS/MEFLOQUINE
  • STRONG CYP3A4 INHIBITORS/ZANUBRUTINIB
  • SELECTED STRONG CYP3A4 INHIBITORS/ILOPERIDONE
  • IDELALISIB/SELECTED BENZODIAZEPINES
  • STRONG CYP3A4 INHIBITORS/BREXPIPRAZOLE
  • STRONG CYP3A4 INHIBITORS/MIDOSTAURIN
  • STRONG CYP3A4 INHIBITORS/PIMAVANSERIN (<= 10 MG)
  • SELECTED CYP3A4 INHIBITORS/BROMOCRIPTINE; CABERGOLINE
  • SELECTED CYP3A4 INHIBITORS/FELODIPINE
  • STRONG 3A4 INHIB/LEVOMILNACIPRAN(<=80MG);VILAZODONE(<=20MG)
  • STRONG CYP3A4 INHIBITORS/VARDENAFIL (<=2.5 MG)
  • STRONG CYP3A4 INHIBITORS/PANOBINOSTAT (<= 10 MG)
  • STRONG CYP3A4 INHIB;ATAZANAV;DARUNAVIR/SAXAGLIPTIN(<=2.5 MG)
  • CYP3A4; CYP2C8; P-GLYCOPROTEIN (P-GP) INHIBITORS/LOPERAMIDE
  • STRONG CYP3A4 INHIBITORS/BUSPIRONE
  • STRONG CYP3A4 INHIBITORS/ESZOPICLONE; ZOPICLONE; ZOLPIDEM
  • STRONG CYP3A4 INHIBITORS/CINACALCET
  • STRONG CYP3A4 INHIBITORS; ATAZANAVIR; DARUNAVIR/ARIPIPRAZOLE
  • SELECTED STRONG CYP3A4 INHIBITORS/ARTEMETHER;LUMEFANTRINE
  • STRONG CYP3A4 INHIBITORS/SLT LOW STRENGTH ANTIMUSCARINICS
  • SLT STRONG & MODERATE CYP3A4 INHIBITORS/CILOSTAZOL (<=50MG)
  • SLT STRONG CYP3A4 INHIBITORS/SILDENAFIL (ED); TADALAFIL (ED)
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    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.