If you are:
Only When Necessary: CROSSES HUMAN PLACENTA & FOUND IN FETAL TISSUE;MANUFACT. RECOMMENDS NOT USING.
Precaution: INSUFFICIENT HUMAN DATA AVAILABLE; ANIMAL DATA SUGGEST EXCRETION
An adult over 60:
management or monitoring precaution: Cardiovascular-Box warning states drug may cause or exacerbate CHF. Contraindicated in patients with NYHA Class III or IV heart failure. Monitor for weight gain, peripheral edema and new onset dyspnea. Hepatic-Monitor for elevations of serum transaminases. Musculoskeletal-Consider increased fracture risk.
Giving Avandia to a child under 12:
management or monitoring precaution: Insufficient efficacy data to support pediatric use. Pediatric studies demonstrated less effect in lowering fasting glucose from baseline when compared to metformin.