Rarely, a serious (sometimes fatal) brain condition (encephalopathy) has occurred in people receiving this medication. Low levels of vitamin B1 (thiamine) can increase your risk. Your doctor will check your thiamine blood levels before starting this medication and regularly during treatment. Get medical help right away if you develop symptoms of encephalopathy such as mental/mood changes (including confusion, trouble thinking clearly, memory loss), balance/walking problems, or eye problems (such as double/blurred vision or unusual eye movements).


This medication is used to treat a certain type of cancer (myelofibrosis). Fedratinib belongs to a class of drugs known as kinase inhibitors. It works by slowing or stopping the growth of cancer cells.

How to use Inrebic 100 Mg Capsule Antineoplastic - Janus Kinase (JAK) Inhibitors

Read the Medication Guide provided by your pharmacist before you start taking fedratinib and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once daily. If you have nausea or vomiting, it may help to take this medication with a high-fat meal.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the capsules.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.