Uses

This medication is used to treat certain types of cancer (such as lung cancer, thyroid cancer, medullary thyroid cancer - MTC). Selpercatinib belongs to a class of drugs known as kinase inhibitors. It works by slowing or stopping the growth of cancer cells.

How to use

Read the Patient Information Leaflet if available from your pharmacist before you start taking selpercatinib and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually twice daily (every 12 hours).

Swallow the capsules whole. Do not crush or chew the capsules.

The dosage is based on your weight, medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). If you have certain side effects, your doctor may adjust your dose or stop treatment for some time.

Medications which reduce or block stomach acid (such as proton pump inhibitors-PPIs, H2 blockers, antacids) may reduce the absorption of selpercatinib, making it work less well. If you take a PPI (such as omeprazole, lansoprazole), take selpercatinib with food. If you take an antacid, take selpercatinib at least 2 hours before or 2 hours after taking the antacid. If you take a H2 blocker (such as famotidine, ranitidine), take selpercatinib at least 2 hours before or at least 10 hours after taking the H2 blocker.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase.

If you vomit your dose of selpercatinib, do not take another dose. Take your next dose at your regular scheduled time. Do not take two doses at the same time.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.