Read the Patient Information Leaflet if available from your pharmacist before you start taking dolutegravir and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Do not change dosage forms of this medication without checking with your doctor or pharmacist.
Take this medication by mouth with or without food as directed by your doctor, usually 1 to 2 times daily.
The tablet(s) may be swallowed whole or mixed in water. Do not chew, cut, or crush the tablet(s).
If you are mixing the tablet(s) in water, place the tablet(s) in the supplied cup with a small amount of water. Ask your doctor or pharmacist how much water you should use to dissolve the tablet(s). Do not use any other liquids. Swirl the mixture gently for 1 to 2 minutes, then drink all of the mixture right away. To make sure you have taken all of the medication, add another small amount of water to the cup, swirl it, and drink it right away. Take this medication within 30 minutes of mixing.
Take this medication at least 2 hours before or 6 hours after taking sucralfate and products containing aluminum or magnesium (such as antacids, laxatives, buffered medications). These products bind with dolutegravir, decreasing its effectiveness.
If you are also taking calcium or iron supplements (including vitamins/minerals that contain calcium or iron), take dolutegravir at least 2 hours before or 6 hours after these products. Or, if you take dolutegravir with food, you can take calcium or iron supplements at the same time.
The dosage is based on your medical condition, response to treatment, age, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). In children, the dosage is also based on weight.
It is very important to keep taking this medication (and other HIV medications) exactly as prescribed by your doctor. Do not skip any doses.
For the best effect, take this medication at evenly spaced times. To help you remember, take this medication at the same time(s) every day.
Do not take more or less of this drug than prescribed or stop taking it (or other HIV medicines) even for a short time unless directed to do so by your doctor. Doing so may cause the amount of virus to increase, make the infection more difficult to treat (resistant), or worsen side effects.