COMMON side effects

If experienced, these tend to have a Severe expression i

• an infection
• low levels of white blood cells
• low levels of a type of white blood cell called neutrophils
• inflammation of the esophagus

If experienced, these tend to have a Less Severe expression i

• hair loss
• nausea
• vomiting
• abnormal color of urine

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

• cardiomyopathy, a disease of the heart muscle
• chronic heart failure
• fibrous hardening of the walls of the veins
• stomach or intestinal ulcer
• redness of skin following radiation therapy
• reactions at the site of the injection
• tissue death

If experienced, these tend to have a Less Severe expression i

• increased sensitivity of the skin to the sun
• diarrhea

RARE side effects

If experienced, these tend to have a Severe expression i

• dehydration
• significantly decreased activity of the bone marrow
• decreased blood platelets
• a disorder of the peripheral nerves that enable movement called peripheral motor neuropathy
• inflammation of the covering of the heart or pericardium
• abnormal heart electrical signals
• rapid ventricular heartbeat
• ventricular premature beats
• slow heartbeat
• sinus tachycardia, a type of fast heart rate
• left ventricular heart failure
• inflammation of the middle tissue heart muscle
• toxicity to the heart
• obstruction of a blood vessel by a blood clot
• myelodysplastic syndrome, a bone marrow disorder
• coma
• seizures
• erythrodysesthesia or tingling, pain, redness, and edema in the hands and feet
• trouble breathing
• a significant type of allergic reaction called anaphylaxis
• damage to the skin and tissue around the injection site
• tissue death or necrosis in the intestinal colon
• therapy-related acute myeloid leukemia
• radiation recall syndrome
• a high alanine transaminase level
• a high aspartate transaminase level
• tumor lysis syndrome

If experienced, these tend to have a Less Severe expression i

• inflammation of the cornea of the eye
• pink eye
• excessive watery eyes
• itching
• discoloration of nail
• skin discoloration
• darkening of the skin
• fever
• chills
• decreased appetite
• weight gain
• generalized weakness
• a feeling of general discomfort called malaise
• intense abdominal pain
• hyperpigmentation of the inside of the mouth
• drug-induced hot flashes
• peripheral sensory nerve disorder