Less estrogen can lead to vaginal dryness, itching, and irritation, which may make intercourse uncomfortable or painful. Try using a water-based lubricant. Your desire may go up or down, but many things besides menopause -- including stress, medications, depression, poor sleep, and relationship problems -- affect sex drive. Talk to your doctor if you have sex problems -- don't settle for a so-so sex life. And remember, sexually transmitted diseases (STDs) don't end with menopause. You still need to use protection.