Ivabradine/Strong CYP3A4 Inducers Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Some medicines may speed up how quickly your liver processes ivabradine.

What might happen:

The amount of ivabradine in your blood may decrease and it may not work as well.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change the dose of your ivabradine and monitor you more closely. Let your healthcare professionals know if you stop taking your other medicine. The dose of your ivabradine may need adjusting. Let your doctor know if your resting heart rate is greater than 60 beats per minutes and/or if you have any increased swelling or shortness of breath.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Procoralan (ivabradine hydrochloride) summary of product characteristics. Les Laboratoires Servier March, 2015.
  • 2.Corlanor (ivabradine) US prescribing information. Amgen, Inc. April, 2019.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.