CYCLOPHOSPHAMIDE Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • an infection
  • a reduction in the body's resistance to infection
  • low levels of white blood cells
  • low levels of a type of white blood cell called neutrophils
  • If experienced, these tend to have a Less Severe expression i

  • irregular periods
  • discoloration of nail
  • hair loss
  • darkening of the skin
  • fever
  • decreased appetite
  • nausea
  • vomiting
  • diarrhea
  • INFREQUENT side effects

    If experienced, these tend to have a Severe expression i

  • a disorder with excess antidiuretic hormone called syndrome of inappropriate antidiuretic hormone
  • anemia
  • decreased blood platelets
  • damage to the kidneys
  • inflammation of the bladder with hemorrhage
  • a yellowing of the eyes or skin from buildup of bilirubin called jaundice
  • tumor lysis syndrome
  • If experienced, these tend to have a Less Severe expression i

  • low sperm count
  • absence of menstrual periods
  • excessive sweating
  • temporary redness of face and neck
  • headache
  • intense abdominal pain
  • RARE side effects

    If experienced, these tend to have a Severe expression i

  • thyroid cancer
  • cancer of the bladder
  • low amount of sodium in the blood
  • hemolytic uremic syndrome, a condition that affects the kidney and the blood
  • a type of blood clotting disorder called disseminated intravascular coagulation
  • a type of brain function problem called encephalopathy
  • hearing loss
  • high blood pressure
  • a heart attack
  • a clot in the lung
  • pulmonary hypertension
  • acute inflammation of the covering of the heart
  • pericardial tamponade, a disorder of the heart
  • fluid in the covering of the heart or pericardium
  • atrial fibrillation
  • atrial flutter
  • ventricular arrhythmias, a type of abnormal heart rhythm
  • supraventricular arrhythmias, a type of abnormal heart rhythm
  • heart failure
  • inflammation of the middle tissue heart muscle
  • hepatic veno-occlusive disease, a type of liver disease
  • blood clot formation in vein
  • low blood pressure
  • inadequate blood flow in the extremities
  • a type of inflammation of the lung called interstitial pneumonitis
  • a condition where there is formation of fibrous tissue in the lung called pulmonary fibrosis
  • bronchospasm
  • stomatitis, a condition with painful swelling and sores inside the mouth
  • inflammation of the large intestine
  • inflammation of the lining of the stomach and intestines
  • liver failure
  • inflammation of the liver called hepatitis
  • blockage of normal bile flow
  • acute inflammation of the pancreas
  • bleeding of the stomach or intestines
  • kidney failure
  • inflammation of the bladder
  • inflammation of the skin due to an allergy
  • erythema multiforme, a type of allergic skin reaction
  • a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome
  • itching
  • hives
  • scleroderma, hardening and tightening of the skin and connective tissues
  • a condition with muscle tissue breakdown called rhabdomyolysis
  • myelodysplastic syndrome, a bone marrow disorder
  • seizures
  • a skin rash
  • erythrodysesthesia or tingling, pain, redness, and edema in the hands and feet
  • trouble breathing
  • an enlarged liver
  • high blood sugar
  • abnormal liver function tests
  • impaired wound healing
  • a significant type of allergic reaction called anaphylaxis
  • a type of allergic reaction called angioedema
  • reactions at the site of the injection
  • infertility
  • lung tissue problem
  • pulmonary veno-occlusive disease
  • a type of brain disorder called posterior reversible encephalopathy syndrome
  • an abnormal bleed in the heart muscle
  • radiation recall syndrome
  • If experienced, these tend to have a Less Severe expression i

  • water retention
  • confusion
  • pink eye
  • excessive watery eyes
  • ringing in the ears
  • inflammation of the parotid gland
  • constipation
  • muscle spasm
  • taste impairment
  • a distorted sense of smell called parosmia
  • pain in the oropharynx
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    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.