Doxepin HCL Capsule

COMMON BRAND(S): Sinequan

GENERIC NAME(S): Doxepin

WARNINGS:

Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.

Who should not take Doxepin HCL Capsule?

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Uses

Uses

This medication is used to treat mental/mood problems such as depression and anxiety. It may help improve mood and feelings of well-being, relieve anxiety and tension, help you sleep better, and increase your energy level. This medication belongs to a class of medications called tricyclic antidepressants. It works by affecting the balance of certain natural chemicals (neurotransmitters) in the brain.

How to use Doxepin HCL Capsule

Read the Medication Guide provided by your pharmacist before you start taking doxepin and each time you get a refill. If you have any questions, consult your doctor or pharmacist.

Take this medication by mouth, usually 1 to 3 times daily or as directed by your doctor. If you take it only once a day, take it at bedtime to reduce daytime sleepiness. The dosage is based on your medical condition and response to treatment.

To reduce your risk of side effects (such as drowsiness, dry mouth, dizziness), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.

Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time(s) each day. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

It is important to continue taking this medication even if you feel well. Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Also, you may experience symptoms such as mood swings, headache, and tiredness. To prevent these symptoms while you are stopping treatment with this drug, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details. Report any new or worsening symptoms right away.

This medication may not work right away. You may see some benefit within a week. However, it may take up to 3 weeks before you feel the full effect.

Tell your doctor if your condition persists or worsens (such as your feelings of sadness get worse, or you have thoughts of suicide).

Side Effects

Side Effects

See also Warning section.

Drowsiness, dizziness, dry mouth, blurred vision, constipation, or trouble urinating may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.

To prevent constipation, eat dietary fiber, drink enough water, and exercise. You may also need to take a laxative. Ask your pharmacist which type of laxative is right for you.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these rare but serious side effects occur: persistent heartburn, mental/mood changes (such as anxiety, agitation, confusion), shaking, severe stomach/abdominal pain.

Get medical help right away if you have any very serious side effects, including: severe dizziness, fast/irregular heartbeat, fainting, seizures, eye pain/swelling/redness, widened pupils, vision changes (such as seeing rainbows around lights at night).

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Precautions

See also Warning section.

Before taking doxepin, tell your doctor or pharmacist if you are allergic to it; or to other tricyclic antidepressants (such as nortriptyline); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding problems, breathing problems, liver problems, recent heart attack, problems urinating (such as due to enlarged prostate), overactive thyroid (hyperthyroidism), personal or family history of glaucoma (angle-closure type), personal or family history of mental/mood conditions (such as bipolar disorder, psychosis), family history of suicide, seizures, conditions that may increase your risk of seizures (such as other brain disease, alcohol/sedative withdrawal).

Doxepin may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using doxepin, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using doxepin safely.

This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

If you have diabetes, this drug may make it harder to control your blood sugar levels. Monitor your blood sugar levels regularly and tell your doctor of the results. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

Older adults may be more sensitive to the side effects of this drug, especially dry mouth, dizziness, drowsiness, confusion, difficulty urinating, and QT prolongation (see above).

During pregnancy, this medication should be used only when clearly needed. Since untreated mental/mood problems (such as depression, anxiety) can be a serious condition, do not stop using this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.

This medication passes into breast milk and may have undesirable effects on a nursing infant. Breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Interactions

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: arbutamine, thyroid supplements, anticholinergic drugs (such as benztropine, belladonna alkaloids), central-acting drugs to treat high blood pressure (such as clonidine, guanabenz).

Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Ask your doctor when to start or stop taking this medication.

Other medications can affect the removal of doxepin from your body, thereby affecting how doxepin works. These drugs include cimetidine, St. John's Wort, terbinafine, drugs to treat irregular heart rate (such as quinidine/propafenone/flecainide), antidepressants (such as SSRIs including paroxetine/fluoxetine/fluvoxamine). This is not a complete list.

Many drugs besides doxepin may affect the heart rhythm (QT prolongation in the EKG), including amiodarone, cisapride, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin), among others. Therefore, before using doxepin, report all medications you are currently using to your doctor or pharmacist.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), other drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain decongestants or ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Overdose

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: extreme drowsiness, hallucinations, fast/irregular heartbeat, fainting, slow/shallow breathing, seizures.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as blood counts, blood pressure, EKG, liver tests) may be performed from time to time to monitor your progress or check for side effects. Keep all medical appointments. Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Storage

Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.Information last revised October 2018. Copyright(c) 2018 First Databank, Inc.

Images
doxepin 25 mg capsule
doxepin 25 mg capsuleiconicon
doxepin 25 mg capsule

color
ivory,white
shape
oblong
imprint
MYLAN 3125, MYLAN 3125
doxepin 100 mg capsule
doxepin 100 mg capsuleiconicon
doxepin 100 mg capsule

color
bright light green,white
shape
oblong
imprint
MYLAN 6410, MYLAN 6410
doxepin 10 mg capsule
doxepin 10 mg capsuleiconicon
doxepin 10 mg capsule

color
buff
shape
oblong
imprint
MYLAN 1049, MYLAN 1049
doxepin 50 mg capsule
doxepin 50 mg capsuleiconicon
doxepin 50 mg capsule

color
ivory
shape
oblong
imprint
MYLAN 4250, MYLAN 4250
doxepin 75 mg capsule
doxepin 75 mg capsuleiconicon
doxepin 75 mg capsule

color
bright light green
shape
oblong
imprint
MYLAN 5375, MYLAN 5375
doxepin 150 mg capsule
doxepin 150 mg capsuleiconicon
doxepin 150 mg capsule

color
white,blue
shape
oblong
imprint
par 222, par 222
doxepin 25 mg capsule
doxepin 25 mg capsuleiconicon
doxepin 25 mg capsule

color
yellow,white
shape
oblong
imprint
AMNEAL, 1170
doxepin 10 mg capsule
doxepin 10 mg capsuleiconicon
doxepin 10 mg capsule

color
buff
shape
oblong
imprint
par 217, par 217
doxepin 25 mg capsule
doxepin 25 mg capsuleiconicon
doxepin 25 mg capsule

color
ivory,white
shape
oblong
imprint
par 218, par 218
doxepin 50 mg capsule
doxepin 50 mg capsuleiconicon
doxepin 50 mg capsule

color
ivory
shape
oblong
imprint
par 219, par 219
doxepin 75 mg capsule
doxepin 75 mg capsuleiconicon
doxepin 75 mg capsule

color
bright light green
shape
oblong
imprint
par 220, par 220
doxepin 100 mg capsule
doxepin 100 mg capsuleiconicon
doxepin 100 mg capsule

color
bright light green,white
shape
oblong
imprint
par 221, par 221
doxepin 10 mg capsule
doxepin 10 mg capsuleiconicon
doxepin 10 mg capsule

color
yellow
shape
oblong
imprint
AMNEAL, 1166
doxepin 50 mg capsule
doxepin 50 mg capsuleiconicon
doxepin 50 mg capsule

color
yellow
shape
oblong
imprint
AMNEAL, 1171
doxepin 100 mg capsule
doxepin 100 mg capsuleiconicon
doxepin 100 mg capsule

color
bright light green,white
shape
oblong
imprint
DOX, 100
doxepin 75 mg capsule
doxepin 75 mg capsuleiconicon
doxepin 75 mg capsule

color
bright light green
shape
oblong
imprint
DOX, 75
doxepin 50 mg capsule
doxepin 50 mg capsuleiconicon
doxepin 50 mg capsule

color
ivory
shape
oblong
imprint
DOX, 50
doxepin 25 mg capsule
doxepin 25 mg capsuleiconicon
doxepin 25 mg capsule

color
ivory,white
shape
oblong
imprint
DOX, 25
doxepin 10 mg capsule
doxepin 10 mg capsuleiconicon
doxepin 10 mg capsule

color
buff
shape
oblong
imprint
DOX, 10
doxepin 75 mg capsule
doxepin 75 mg capsuleiconicon
doxepin 75 mg capsule

color
green
shape
oblong
imprint
AMNEAL, 1172
doxepin 100 mg capsule
doxepin 100 mg capsuleiconicon
doxepin 100 mg capsule

color
green,white
shape
oblong
imprint
AMNEAL, 1173
doxepin 25 mg capsule
doxepin 25 mg capsule

color
ivory,white
shape
oblong
imprint
MYLAN 3125, MYLAN 3125
This medicine is a ivory white, oblong, capsule imprinted with "MYLAN 3125" and "MYLAN 3125".
doxepin 100 mg capsule
doxepin 100 mg capsule

color
bright light green,white
shape
oblong
imprint
MYLAN 6410, MYLAN 6410
This medicine is a bright light green white, oblong, capsule imprinted with "MYLAN 6410" and "MYLAN 6410".
doxepin 10 mg capsule
doxepin 10 mg capsule

color
buff
shape
oblong
imprint
MYLAN 1049, MYLAN 1049
This medicine is a buff, oblong, capsule imprinted with "MYLAN 1049" and "MYLAN 1049".
doxepin 50 mg capsule
doxepin 50 mg capsule

color
ivory
shape
oblong
imprint
MYLAN 4250, MYLAN 4250
This medicine is a ivory, oblong, capsule imprinted with "MYLAN 4250" and "MYLAN 4250".
doxepin 75 mg capsule
doxepin 75 mg capsule

color
bright light green
shape
oblong
imprint
MYLAN 5375, MYLAN 5375
This medicine is a bright light green, oblong, capsule imprinted with "MYLAN 5375" and "MYLAN 5375".
doxepin 150 mg capsule
doxepin 150 mg capsule

color
white,blue
shape
oblong
imprint
par 222, par 222
This medicine is a white blue, oblong, capsule imprinted with "par 222" and "par 222".
doxepin 25 mg capsule
doxepin 25 mg capsule

color
yellow,white
shape
oblong
imprint
AMNEAL, 1170
This medicine is a yellow white, oblong, capsule imprinted with "AMNEAL" and "1170".
doxepin 10 mg capsule
doxepin 10 mg capsule

color
buff
shape
oblong
imprint
par 217, par 217
This medicine is a buff, oblong, capsule imprinted with "par 217" and "par 217".
doxepin 25 mg capsule
doxepin 25 mg capsule

color
ivory,white
shape
oblong
imprint
par 218, par 218
This medicine is a ivory white, oblong, capsule imprinted with "par 218" and "par 218".
doxepin 50 mg capsule
doxepin 50 mg capsule

color
ivory
shape
oblong
imprint
par 219, par 219
This medicine is a ivory, oblong, capsule imprinted with "par 219" and "par 219".
doxepin 75 mg capsule
doxepin 75 mg capsule

color
bright light green
shape
oblong
imprint
par 220, par 220
This medicine is a bright light green, oblong, capsule imprinted with "par 220" and "par 220".
doxepin 100 mg capsule
doxepin 100 mg capsule

color
bright light green,white
shape
oblong
imprint
par 221, par 221
This medicine is a bright light green white, oblong, capsule imprinted with "par 221" and "par 221".
doxepin 10 mg capsule
doxepin 10 mg capsule

color
yellow
shape
oblong
imprint
AMNEAL, 1166
This medicine is a yellow, oblong, capsule imprinted with "AMNEAL" and "1166".
doxepin 50 mg capsule
doxepin 50 mg capsule

color
yellow
shape
oblong
imprint
AMNEAL, 1171
This medicine is a yellow, oblong, capsule imprinted with "AMNEAL" and "1171".
doxepin 100 mg capsule
doxepin 100 mg capsule

color
bright light green,white
shape
oblong
imprint
DOX, 100
This medicine is a bright light green white, oblong, capsule imprinted with "DOX" and "100".
doxepin 75 mg capsule
doxepin 75 mg capsule

color
bright light green
shape
oblong
imprint
DOX, 75
This medicine is a bright light green, oblong, capsule imprinted with "DOX" and "75".
doxepin 50 mg capsule
doxepin 50 mg capsule

color
ivory
shape
oblong
imprint
DOX, 50
This medicine is a ivory, oblong, capsule imprinted with "DOX" and "50".
doxepin 25 mg capsule
doxepin 25 mg capsule

color
ivory,white
shape
oblong
imprint
DOX, 25
This medicine is a ivory white, oblong, capsule imprinted with "DOX" and "25".
doxepin 10 mg capsule
doxepin 10 mg capsule

color
buff
shape
oblong
imprint
DOX, 10
This medicine is a buff, oblong, capsule imprinted with "DOX" and "10".
doxepin 75 mg capsule
doxepin 75 mg capsule

color
green
shape
oblong
imprint
AMNEAL, 1172
This medicine is a green, oblong, capsule imprinted with "AMNEAL" and "1172".
doxepin 100 mg capsule
doxepin 100 mg capsule

color
green,white
shape
oblong
imprint
AMNEAL, 1173
This medicine is a green white, oblong, capsule imprinted with "AMNEAL" and "1173".

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.