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What is the role of dopamine in schizophrenia?

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People who have schizophrenia may hear voices or see things that aren’t real. Dopamine gets a lot of attention in brain research because it’s been linked to addiction. It also plays a role in other psychiatric and movement disorders, like Parkinson’s disease.

In schizophrenia, dopamine is tied to hallucinations and delusions. That’s because brain areas that "run" on dopamine may become overactive. Antipsychotic drugs stop this.

SOURCES:

Rubio, M. , published online January 2012. Biomolecules & Therapeutics

National Institute of Mental Health: “Schizophrenia.”

Brisch, R., , published online May 2014. Frontiers in Psychiatry

Vaibhav A. Diwadkar, PhD, associate professor, psychiatry and behavioral neurosciences; co-director, Brain Imaging Research division, Wayne State University School of Medicine, Detroit. 

Columbia University Medical Center: “High Levels of Glutamate in Brain May Kick-Start Schizophrenia,” published online April 2013.

Reviewed by Jennifer Casarella on December 4, 2019

SOURCES:

Rubio, M. , published online January 2012. Biomolecules & Therapeutics

National Institute of Mental Health: “Schizophrenia.”

Brisch, R., , published online May 2014. Frontiers in Psychiatry

Vaibhav A. Diwadkar, PhD, associate professor, psychiatry and behavioral neurosciences; co-director, Brain Imaging Research division, Wayne State University School of Medicine, Detroit. 

Columbia University Medical Center: “High Levels of Glutamate in Brain May Kick-Start Schizophrenia,” published online April 2013.

Reviewed by Jennifer Casarella on December 4, 2019

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What is the role of glutamate in schizophrenia?

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